p-Iodophenol
4-Iodophenol
CAS: 540-38-5
Molecular Formula: C6H5IO
p-Iodophenol - Names and Identifiers
| Name | 4-Iodophenol |
| Synonyms | 4-iodo-pheno p-Iodophenol p-iodo-pheno P-IODOPHENOL 4-Iodophenol I**4-Iodophenol Phenol, p-iodo- p-hydroxyiodobenzene 4-hydroxyiodobenzene 4-hydroxyphenyliodide |
| CAS | 540-38-5 |
| EINECS | 208-745-5 |
| InChI | InChI=1/C6H5IO/c7-5-1-3-6(8)4-2-5/h1-4,8H |
p-Iodophenol - Physico-chemical Properties
| Molecular Formula | C6H5IO |
| Molar Mass | 220.01 |
| Density | 1.8573 |
| Melting Point | 92-94°C(lit.) |
| Boling Point | 138°C5mm Hg(lit.) |
| Flash Point | 138°C/5mm |
| Water Solubility | slightly soluble |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.00146mmHg at 25°C |
| Appearance | Crystals or Crystalline Powder |
| Color | Pink or beige to brown |
| Merck | 14,5036 |
| BRN | 1904544 |
| pKa | 9.33(at 25℃) |
| Storage Condition | Refrigerator |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Light Sensitive |
| Refractive Index | 1.669 |
| Physical and Chemical Properties | Character: colorless needle-like crystals. melting point 93~94 ℃ boiling point 138 ℃(0.67kPa) solubility slightly soluble in water, soluble in ethanol, ether and other organic solvents. |
| Use | Can be used as disinfectants or intermediates in organic synthesis |
p-Iodophenol - Risk and Safety
| Risk Codes | R21/22 - Harmful in contact with skin and if swallowed. R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S22 - Do not breathe dust. |
| UN IDs | UN 3261 8/PG 3 |
| WGK Germany | 3 |
| RTECS | SL5600000 |
| TSCA | T |
| HS Code | 29081900 |
| Hazard Note | Irritant |
| Hazard Class | IRRITANT, LACHRYMATO |
p-Iodophenol - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | can be used as disinfectant or organic synthesis intermediate the product is condensed with chloroacetic acid to obtain p-iodophenoxyacetic acid. This is a plant growth regulator, also known as Zengzanling; it is also used for fattening and fattening of live pigs, so it is also called Fat Pig Spirit. P-iodophenol is also used in other organic synthesis. |
| production method | is obtained by diazotization and replacement of p-aminophenol. The mixed solution of p-aminophenol, water and sulfuric acid is cooled to 0 ℃, and the sodium nitrite solution is added within 1h under stirring. After adding, continue stirring for 20min, then add concentrated sulfuric acid to obtain diazotized solution. Pour the diazotization solution into the cold potassium iodide solution, add copper powder, and stir at 75-80 ℃, and react until no nitrogen is released. Cool to room temperature, extract three times with chloroform, combine the extract, and wash with a dilute solution of sodium thiosulfate. Recover chloroform by distillation. The distilled residue was distilled under reduced pressure, and the fraction at 135-140 ℃(61.3kPa) was collected, and cooled and crystallized to obtain crude p-iodophenol. Crystallized with dilute ethanol to make fine products. The yield is about 70%. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | abdominal cavity-mouse LD50: 700 mg/kg |
| flammability hazard characteristics | open flame flammability |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | carbon dioxide, sand, foam, dry powder, mist water |
Last Update：2024-04-09 02:00:09
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