pirviniumpamoate
PYRVINIUM PAMOATE
CAS: 3546-41-6
Molecular Formula: C75H70N6O6
pirviniumpamoate - Names and Identifiers
pirviniumpamoate - Physico-chemical Properties
| Molecular Formula | C75H70N6O6 |
| Molar Mass | 1151.39 |
| Density | 1.0104 (rough estimate) |
| Melting Point | 210-215° (softens at 190°) |
| Boling Point | 829.27°C (rough estimate) |
| Solubility | DMSO: 24 mg/mL (41.69 mM)( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| Appearance | powder |
| Color | red |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6400 (estimate) |
| Use | Pyrvinium pamoate is an FDA-approved anti-worm drug that inhibits WNT pathway signaling. |
| Target | Wnt |
| In vitro study | Pyrvinium pamoate (0-500 nM) inhibits proliferation of MCF-7 (luminal), MDA-MB-231 (claudin-low), MDA-MB-468 (basal-like) and SkBr3 (HER2-OE) cells in a dose-dependent manner, with IC 50 value of 1170±105.0 nM against MDA-MB-231 cell line. Pyrvinium pamoate significantly inhibits self-renewal and proliferation of BCSCs, and suppresses BCSC population with a distinct phenotype. Pyrvinium pamoate significantly decreases average expression levels of FZD1, FZD10, WNT1, WNT7B, CTNNB1, MYC, and LRP5 at transcriptional level. Moreover, Pyrvinium pamoate also efficiently down-regulates the expression of other stemness genes including ALDH1, CD44 and ABCG2. Pyrvinium pamoate blocks colon cancer cell growth in vitro in a dose-dependent manner with great differences in the inhibitory concentration (IC 50 ), ranging from 0.6 to 65 μM for colon cancer cells with mutations in WNT signaling. Pyrvinium pamoate decreases messenger RNA (mRNA) and protein levels of known WNT target genes as c-MYC and thereby led to the induction of p21. Pyrvinium pamoate ultimately inhibits Wnt signalling despite its lack of efficacy on CK1. Pyrvinium pamoate imposes specific toxicity on cardiac fibroblasts in ischemia (IC 50 =9.5 nM). The cytotoxic effect of Pyrvinium pamoate on cardiac fibroblasts specifically under glucose- and glutamine-deficient condition. |
| In vivo study | In the xenograft model, Pyrvinium pamoate (500 nM)-pretreatment strongly delays tumor size and tumor weight, and the tumor volume is markedly decreased. |
pirviniumpamoate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 2933492250 |
pirviniumpamoate - Reference
| Reference Show more | 1. Zheng L , Liu Y , Pan J . Inhibitory effect of pyrvinium pamoate on uveal melanoma cells involves blocking of Wnt/β-catenin pathway[J].2017(49):898.2. Xu F , Zhu Y , Lu Y , et al. Anthelmintic pyrvinium pamoate blocks Wnt/β-catenin and induces apoptosis in multiple myeloma cells[J]. Oncology Letters, 2018.3. Xu L, et al. WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells. Int J Oncol. 2016 Mar;48(3):1175-86. |
pirviniumpamoate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.869 ml | 4.343 ml | 8.685 ml |
| 5 mM | 0.174 ml | 0.869 ml | 1.737 ml |
| 10 mM | 0.087 ml | 0.434 ml | 0.869 ml |
| 5 mM | 0.017 ml | 0.087 ml | 0.174 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: PYRVINIUM PAMOATE Visit Supplier Webpage Request for quotationCAS: 3546-41-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: PYRVINIUM PAMOATE Visit Supplier Webpage Request for quotationCAS: 3546-41-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History