polybrene

polybrene - Names and Identifiers

Name	polybrene
Synonyms	polybrene NSC 118096 hexadimethrine forproteinsequenceanalysis HEXADIMETHRIN BROMIDE FOR PROTEIN 1,5-dimethyl-1,5-d-diazaundecamethylenepolymethobromide n,n,n',n'-tetramethylhexamethylenediamine-1,3-dibromopropanecopolymer 1,6-hexanediamine,n,n,n',n'-tetramethyl-,polymerwith1,3-dibromopropane propane,1,3-dibromo-,polymerwithn,n,n',n'-tetramethyl-1,6-hexanediamine
CAS	9011-04-5

polybrene - Physico-chemical Properties

Molecular Formula	C13H30Br2N2
Molar Mass	374.21
Solubility	H2O: 0.1g/mL, clear to slightly hazy, colorless to faintly yellow
Appearance	Liquid
Storage Condition	2-8°C
Use	Cell culture is mainly used to improve the efficiency of retrovirus infection of cells by neutralizing the charge rejection between sialic acid and virus particles on the cell surface. Polyamine also has a role in protein sequencing.

polybrene - Risk and Safety

UN IDs	2811
WGK Germany	3
RTECS	TQ2655000
FLUKA BRAND F CODES	3-10
Hazard Class	6.1(b)
Packing Group	III

polybrene - Introduction

polybrene(Polybrene) is a cationic polymer whose chemical name is poly (N-vinyl-4-butenylpyridine hydrochloride). The following is a description of some of the properties, uses, methods and safety information of polybrene:

Nature:
-Appearance: It is a white powder or granular substance.
-Solubility: polybrene easy to dissolve in water, but also can be dissolved in some organic solvents.
-Stability: Under certain conditions, polybrene can exist stably at higher temperatures.
-Ionicity: Since polybrene are cationic polymers, they will usually interact with negatively charged biological macromolecules (such as DNA or RNA), thereby improving their stability and solubility under test conditions.

Use:
-Gene delivery: polybrene is commonly used in the field of gene delivery. It combines with DNA or RNA to form a polymer complex, which can help genes or nucleic acids enter cells to achieve gene therapy or gene transfection.
-Virus amplification: polybrene can be used to enhance the efficiency of the virus amplification or virus packaging process.
-Cell culture: In cell culture experiments, polybrene can be used as injections or additives to improve the interaction between target cells and viruses, thereby increasing the efficiency of virus infection.

Preparation Method:
- polybrene is usually produced by a synthetic method, and the synthesis usually uses 4-butenylpyridine and hydrochloric acid to react to form a polymer.

Safety Information:
-Although polybrene is widely used in many biological experiments, it is necessary to pay attention to safety during operation.
- polybrene powder can cause respiratory tract irritation and inhalation should be avoided. It is recommended to wear appropriate protective masks during operation.
- polybrene may also be irritating to eyes and skin, so avoid contact during operation.
-When using the polybrene, please follow the relevant safety instructions to ensure proper laboratory operation and waste disposal.

Last Update：2024-04-09 21:04:16