| Name | TSH |
| Synonyms | TSH pretiron thytropar dermathycin thyrotrophin thyreotrophichormone thyroid-stimulatingfactor serumthyroid-stimulatinghormone |
| CAS | 9002-71-5 |
| EINECS | 232-664-4 |
| Appearance | lyophilized powder |
| Merck | 13,9870 |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | This product is white or light yellow freeze-dried powder, soluble in water. It is stable at room temperature and rapidly inactivated when heated above 60 ℃. After dissolution, it will not fail within two weeks after low temperature storage. Inactivation of proteolytic enzymes, cystine, oxidants (such as potassium permanganate, iodine), etc. This product is a glycoprotein extracted from the anterior lobe of the pituitary gland. It is composed of two peptide chains of α and β. TSH-α is composed of 96 amino acids with a molecular weight of about 13600. TSH-β contains 112-113 amino acids. The molecular weight is about 14700. The former contains two oligopolysaccharides and the latter contains one oligopolysaccharide. TSH-β chain is specific. The species specificity of TSH is not great, but the TSH of other animals is easy to produce antibodies after being used in humans, so that the effect is weakened. TSH stimulates a series of processes such as iodine uptake, iodine activation, synthesis of T3 and T4, hydrolysis of thyroglobulin and release of T3 and T4. It can also increase the intake of glucose and amino acids by thyroid cells, increase the oxidation of glucose, and enhance the synthesis of RNA and protein; it also makes the fat of adipose tissue break down. When TSH is too much, the thyroid gland is hyperplastic and the blood vessels are abundant. The effect of TSH is that it activates the adenylate cyclase in the thyroid gland to generate cAMP as a second messenger. |
| WGK Germany | 3 |
| RTECS | XP3581600 |
| FLUKA BRAND F CODES | 10-21 |
| definition | thyroid stimulating hormone (TSH) is an important hormone in the human body, which is mainly secreted by the adenohypophysis and participates in the life activities of the human body. Its main function is to control and regulate the activity of the thyroid gland. TSH is an indispensable indicator for clinical identification of thyroid function. Whether thyroid stimulating hormone is high or low, it will cause thyroid health problems. |
| use | application: TSH test, combined with radioactive iodine to identify the lesion site of hypothyroidism patients; For toxic adenomatous goiter, it is used as an adjuvant therapeutic agent to increase the intake of iodine. When radioactive iodine is used to treat thyroid cancer, it can also be used to improve the efficacy. Precautions: It can cause hyperthyroidism and increase the burden on the cardiovascular system. Patients with heart disease and adrenal hypofunction should be used with caution or contraindicated. |