propionitrile,2,3-bis(p-hydroxyphenyl)
2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE
CAS: 1428-67-7
Molecular Formula: C15H13NO2
propionitrile,2,3-bis(p-hydroxyphenyl) - Names and Identifiers
propionitrile,2,3-bis(p-hydroxyphenyl) - Physico-chemical Properties
| Molecular Formula | C15H13NO2 |
| Molar Mass | 239.27 |
| Melting Point | 200.0 to 204.0 °C |
| Water Solubility | Soluble in 1eq. NaOH (30 mM), ethanol (100 mM), DMSO (100 mM), DMF (~30 mg/ml), and water (0.5 mg/ml at 25°C). |
| Solubility | DMSO: soluble10mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| In vitro study | DPN has a 70-fold ERα relative binding affinity selectivity, and it is a full ERα agonist with a 78-fold ERα potency selectivity (EC 50 =0.85 nM for ERβ; EC 50 =66 nM for ERα). DPN (10 nM) prevents morphological alterations from Aβ 1-42 (10 μM)-induced toxicity in cultured cortical neurons. DPN (0.1-100 nM) decreases ROS levels in a non-dose response manner. DPN (0.1-100 nM) significantly reduces Aβ 1-42 -stimulated expression of Bax in a non-dose dependent manner. DPN (0.1-100 nM) reduces activated IL-1 levels induced by Aβ 1-42 treatment on cultured cortical neurons. DPN (0.1-100 nM) suppresses the Aβ 1-42 -upregulated phosphorylation of JNK and p38. |
propionitrile,2,3-bis(p-hydroxyphenyl) - Risk and Safety
| Risk Codes | R36 - Irritating to the eyes R50 - Very Toxic to aquatic organisms |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | UG0900000 |
| Hazard Class | 9 |
propionitrile,2,3-bis(p-hydroxyphenyl) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.179 ml | 20.897 ml | 41.794 ml |
| 5 mM | 0.836 ml | 4.179 ml | 8.359 ml |
| 10 mM | 0.418 ml | 2.09 ml | 4.179 ml |
| 5 mM | 0.084 ml | 0.418 ml | 0.836 ml |
Last Update：2024-01-02 23:10:35
propionitrile,2,3-bis(p-hydroxyphenyl) - Reference Information
| biological activity | DPN (Diarylpropionitrile) is a non-steroidal estrogen receptor beta selective ligand, its EC50 value was 0.85 nM. DPN has neuroprotective effects in many neurological diseases. |
| Animal Model: | Adult Sprague-Dawley female rats (220-250 g), ovariectomized animal models |
| Dosage: | 10 μg/rat |
| Administration: | Subcutaneous injections, daily, for 11 days |
| Result: | Increased swimming and decreased immobility in the FST. |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: 2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE Visit Supplier Webpage Request for quotationCAS: 1428-67-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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