pyridine-3-carboxyL

pyridine-3-carboxyL - Names and Identifiers

Name	5-Chloro-2-methyl-3-pyridinecarboxylic acid
Synonyms	KML-80 KML-46 pyridine-3-carboxyL 5-Chloro-2-methylnicotinic acid 5-chloro-2-Methylpyridine-3-carboxylic acid 5-Chloro-2-methyl-3-pyridinecarboxylic acid 3-Pyridinecarboxylic acid, 5-chloro-2-methyl-
CAS	1092286-30-0

pyridine-3-carboxyL - Physico-chemical Properties

Molecular Formula	C7H6ClNO2
Molar Mass	171.58
Density	1.39
Boling Point	298℃
Flash Point	134℃
pKa	1.53±0.25(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Sensitive	Irritant
MDL	MFCD11557228

pyridine-3-carboxyL - Introduction

5-Chloro-2-methyl-3-pyridinecarboxylic acid, also known as ClMePyCOOH, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 5-Chloro-2-methyl-3-pyridinecarboxylic acid is a colorless or slightly yellow crystalline powder.
-Melting point: about 76-79 ℃.
-Solubility: Soluble in organic solvents such as ether, ethanol and dichloromethane, insoluble in water.

Use:
5-Chloro-2-methyl-3-pyridine carboxylic acid is commonly used as a catalyst and ligand in organic synthesis. It can be used as a ligand of metal-organic compounds to participate in a variety of organic synthesis reactions, such as cross-coupling reactions, oxidation reactions and asymmetric catalytic reactions. In addition, it can also be used to prepare other organic compounds, such as heterocyclic compounds and nitrogen-containing compounds.

Preparation Method:
The preparation method of 5-chloro -2-methyl -3-pyridine carboxylic acid can be obtained by group transfer of pyridine group by methylation. A specific preparation method may be reacting 2-methyl-3-picolinic acid with phosphorus pentachloride (PCl5) to generate 5-chloro-2-methyl-3-picolinic acid chloride, and then reacting with water to form 5-chloro-2-methyl-3-picolinic acid.

Safety Information:
5-Chloro-2-methyl-3-pyridine carboxylic acid has no obvious toxicity under general operating conditions, but as an organic compound, it still needs to pay attention to safe operation. Contact with skin and eyes, should be promptly rinsed with water. In the use of the process should pay attention to protective measures, such as wearing gloves, wear protective glasses and work clothes. When storing, keep away from fire and oxidizing agents, keep sealed, and store in a cool and dry place.

Last Update：2024-04-09 20:52:54