quininebimuriate
quinine dihydrochloride
CAS: 60-93-5
Molecular Formula: C20H26Cl2N2O2
quininebimuriate - Names and Identifiers
| Name | quinine dihydrochloride |
| Synonyms | QUININE DI HCL quininebimuriate Quinine dichloride Quinine Dihydochloride quinine dihydrochloride QUININE DIHYDROCHLORIDE Quinine dihydrochloride powder QuinineDihydrochlorideInjection (8alpha,9R)-6'-methoxycinchonan-9-ol dihydrochloride cinchonan-9-ol,6'-methoxy-,dihydrochloride,(8-alpha,9r) (6-Methoxy-4-quinolyl)(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol dihydrochloride |
| CAS | 60-93-5 |
| EINECS | 200-493-4 |
| InChI | InChI=1/C20H24N2O2.2ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;2*1H/t13-,14-,19-,20+;;/m0../s1 |
quininebimuriate - Physico-chemical Properties
| Molecular Formula | C20H26Cl2N2O2 |
| Molar Mass | 397.34 |
| Melting Point | 238-2400C |
| Boling Point | 495.9°C at 760 mmHg |
| Flash Point | 253.7°C |
| Vapor Presure | 1.19E-10mmHg at 25°C |
| Stability | Stable, but may be light sensitive. Efflorescent. Incompatible with strong oxidizing agents. |
quininebimuriate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 1544 |
| HS Code | 29392000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
quininebimuriate - Standard
Authoritative Data Verified Data
This product is the dihydrochloride salt of 6 '-methoxy-(8a,9R)-cinchonin-9-ol. The content of C2gH24N202 • 2HC1 shall not be less than 99.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
quininebimuriate - Trait
Authoritative Data Verified Data
This product is white powder; Odorless; Light gradient; Acidic aqueous solution reaction.
This product is very soluble in water, soluble in ethanol, slightly soluble in chloroform, very slightly soluble in ether.
specific rotation
take the right amount of this product, precision weighing, add 0.1 mol/L hydrochloric acid solution was dissolved and quantitatively diluted to prepare a solution containing about 30mg per 1ml, which was measured according to law (General rule 0621), and the specific rotation was from 223 ° to 229 °.
Last Update：2022-01-01 11:29:51
quininebimuriate - Differential diagnosis
Authoritative Data Verified Data
- take about 20mg of this product, add 20ml of water to dissolve, take 10ml of solution, Dropwise add dilute sulfuric acid, that is, show blue fluorescence.
- 5ml of the above solution was taken, and 3 drops of bromine test solution and 1ml of ammonia test solution were added, indicating that the solution was green.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 11).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 11:29:51
quininebimuriate - Exam
Authoritative Data Verified Data
acidity
take 0.30g of this product, Add 10ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 2.0~3.0.
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.05% of standard potassium sulfate solution, it should not be more concentrated ().
other Cinchona alkaloids
take this product and prepare a solution containing 10mg per 1ml of methanol as the test solution; Take another control of cinchonidine and prepare a solution containing about 0.25mg per 1ml of methanol, as a control solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions each 5ul, respectively, on the same silica gel G thin layer plate, with toluene-ether-diethylamine (20:12:5) for the development of the solvent, the solvent was developed, dried, repeated for two times, dried, dried at 105 ° C. For 30 minutes, allowed to cool, and sprayed with potassium iodomolybdate test solution to make color development. Test solution such as impurity spots, compared with the control solution of the main spot, not deeper (2.5%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 3.0% (General rule 0831).
ignition residue
not more than 0.15% (General rule 0841).
barium salt
take 0.20g of this product, Add 10ml of water to dissolve, add 1ml of dilute sulfuric acid, and no turbidity will occur within 15 minutes.
Last Update：2022-01-01 11:29:52
quininebimuriate - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add acetic anhydride 5ml and Mercury acetate test solution 3ml dissolved, add crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/ L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1ml of perchloric acid titration solution (0.1 mol/L) corresponds to 19.87mg of C20H24N2O2 · 2HCL.
Last Update：2022-01-01 11:29:53
quininebimuriate - Category
Authoritative Data Verified Data
antimalarial drugs.
Last Update：2022-01-01 11:29:53
quininebimuriate - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:29:53
quininebimuriate - Quinine dihydrochloride injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of quinine dihydrochloride. Quinine dihydrochloride (C20H24N202 • 2HC1) shall be present in the range of 95.0% to 105.0% of the label load.
trait
This product is colorless to yellowish clear liquid.
identification
This product was taken, and the same results were shown according to the tests of (1), (2) and (4) under the items of quinine dihydrochloride.
examination
- the pH value should be not less than 0631 (General rule 1).
- the color of this product, compared with the same volume of the control solution (take 10ml of potassium dichromate solution for color comparison, add water to 20ml), not deeper.
- other Cinchona alkaloids take this product and prepare a solution containing 10mg quinine dihydrochloride per 1 ml in methanol as a test solution. According to the same method for the determination of quinine dihydrochloride and other Cinchona alkaloids, it shall be in accordance with the provisions.
- bacterial endotoxin this product, according to the inspection (General 1143), each 1 mg of quinine dihydrochloride containing endotoxin should be less than 1.0EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take an appropriate amount of this product and dilute it quantitatively with water to make a solution containing 15mg per lml, take 10ml for precise measurement, put it in a separatory funnel and add water to make it 20ml, ammonia Test Solution was added to make it alkaline, and the mixture was extracted by shaking with chloroform, 25ml for the first time and 10ml for each time thereafter. The chloroform solution obtained each time was washed twice with the same water until the quinine was withdrawn, 5ml each time, the washing solution was extracted with 10ml of chloroform by shaking, the chloroform solution was combined, the chloroform was distilled off on a water bath, and the anhydrous ethanol was added to 2ml, then evaporated to dryness, dried at 105°C for 1 hour, and allowed to cool, add 5ml of acetic anhydride and 10ml of glacial acetic acid to dissolve, add 1 drop of crystal violet indicator solution, and use perchloric acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 19.87mg of c20 h24n2o2 · 2HC1.
category
same quinine dihydrochloride.
specification
(l ) lml:0.25g (2) lml:0.5g (3) 2ml:0.25g (4)2ml:0.5g (5)10ml:0.25g
storage
light shielding, closed storage.
Last Update：2022-01-01 11:29:54
quininebimuriate - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Last Update：2024-04-09 02:00:05
