rtca
ribavirin
CAS: 36791-04-5
Molecular Formula: C8H12N4O5
rtca - Names and Identifiers
| Name | ribavirin |
| Synonyms | rtca rtca vilona REBETOL VIRAZID VIRAMID vilona virazid VIRAZOLE viramid virazole RIBAVIRIN ribavirin tribavirin Biopolymers tribavirin 1-pentofuranosyl-1H-1,2,4-triazole-3-carboxamide 1-beta-d-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| CAS | 36791-04-5 |
| EINECS | 636-825-3 |
| InChI | InChI=1/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16) |
| InChIKey | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
rtca - Physico-chemical Properties
| Molecular Formula | C8H12N4O5 |
| Molar Mass | 244.21 |
| Density | 1.4287 (rough estimate) |
| Melting Point | 174-176°C |
| Boling Point | 387.12°C (rough estimate) |
| Specific Rotation(α) | D25 -36.5° (c = 1 in water); D20 -38° (c = 1 in water) |
| Flash Point | 340.7°C |
| Water Solubility | >=10 g/100 mL at 19 ºC |
| Solubility | Soluble in water (20 mg/ml), DMSO (49 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C) |
| Vapor Presure | 3.03E-17mmHg at 25°C |
| Appearance | Colorless solid |
| Color | White |
| Merck | 14,8198 |
| pKa | 12.95±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| Sensitive | Photosensitivity |
| Refractive Index | -36 ° (C=1, H2O) |
| MDL | MFCD00058564 |
| Physical and Chemical Properties | Melting Point 174-176°C water-soluble> = 10g/100 mL at 19°C |
| Use | For broad-spectrum nucleoside antiviral drugs |
rtca - Risk and Safety
| Risk Codes | R61 - May cause harm to the unborn child R36/38 - Irritating to eyes and skin. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | XZ4250000 |
| HS Code | 29349990 |
| Toxicity | LD50 i.p. in mice: 1.3 g/kg; orally in rats: 5.3 g/kg (Witkowski, 1972) |
rtca - Upstream Downstream Industry
| Raw Materials | Inosine |
rtca - Reference
| Reference Show more | 1. Hui, Q. X., et al. "Extraction of total lignans from Radix isatidis and its ant-RSV virus effect." Clin J Pharmacol Pharmacother 1.1 (2019): 1005. 2. [IF=5.81] Lai Yanni et al."Antiviral Activity of Isoimperatorin Against Influenza A Virus in vitro and its Inhibition of Neuraminidase."Front Pharmacol. 2021 Apr;0:588 3. [IF=4.616] Huiwen Wang et al."Rapid quality control of medicine and food dual purpose plant polysaccharides by matrix assisted laser desorption/ionization mass spectrometry."Analyst. 2020 Mar;145(6):2168-2175 |
rtca - Nature
Open Data Verified Data
This product is white crystalline powder, odorless, tasteless. Molecular weight 244. 21. Stable at room temperature. Soluble in water, slightly soluble in ethanol, chloroform and ether. Melting point of 174~176 ℃ or 160~167 ℃ (refined products have two kinds of crystal form). This product is converted into triazole nucleotide in vivo, inhibits hypoxanthine nucleotide dehydrogenase, blocks the biosynthesis of guanosine, thereby inhibiting the synthesis of DNA, with a broad spectrum of Virus (DNA Virus, RNA Virus) and anti-tumor effects.
Last Update：2024-01-02 23:10:35
rtca - Standard
Authoritative Data Verified Data
This product is 1-B-D ribofuranosyl-1h-1, 2, 4-triazole-3-carboxamide. The content of C8H12N405 shall be between 98.5% and 101.5% based on the dry product.
Last Update：2024-01-02 23:10:35
rtca - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless.
- This product is soluble in water, slightly soluble in ethanol, insoluble in ether or methylene chloride.
specific rotation
take this product, precision weighing, add water to dissolve and quantitatively dilute to make a solution containing about 40mg per lml, and determine according to law (General rule 0621), the specific rotation was -35.0 ° to -37.0 °.
Last Update：2022-01-01 11:57:35
rtca - Use
Open Data Verified Data
- It is used for influenza (caused by influenza Virus A and B), Adenovirus Virus, hepatitis A, herpes, measles, etc., and is effective for epidemic hemorrhagic fever. Especially for patients with early curative effect is obvious.
- usage and dosage: 0. 8-lg, 3-4 times a day. Intramuscular injection or intravenous infusion, one day 10~15mg/kg, 2 times slow intravenous infusion. 0.5% solution nasal drops, can prevent influenza, 1 times per hour. 0.1% eye drops for herpes infection, several times a day.
- preparation (1) eye drops 0.1%;(2) nasal drops 0.5%;(3) injection, each lOOmg/mL;(4) tablets: 0. LG/tablet, 0.05g/tablet; (5) buccal tablets: 2mg/tablet.
Last Update：2022-01-01 11:12:49
rtca - Differential diagnosis
Authoritative Data Verified Data
- take about 0.1g of this product, add 10ml of water to dissolve, add 5ml of sodium hydroxide test solution, and heat to boiling, that is, ammonia odor occurs, which can make the moist red litmus paper turn blue.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 22).
Last Update：2022-01-01 11:57:35
rtca - Safety
Open Data Verified Data
oral administration can cause Diarrhea, no other obvious toxicity, but there may be leukopenia; Excessive dose inhibition of hemoglobin and red blood cell maturation and cause reversible anemia. In addition, animal experiments have teratogenic embryotoxicity reports, pregnant women should not use.
Last Update：2022-01-01 11:12:50
rtca - Exam
Authoritative Data Verified Data
acidity
take l.Og of this product, add 50ml of water to dissolve, add 0.2ml of saturated potassium chloride solution, shake well, and measure according to law (General rule 0631). The pH value should be 4.0~6.5.
clarity and color of solution
take 0.5g of this product, add 0902 of water to dissolve, the solution should be clear and colorless; If it is turbid, it should not be more concentrated compared with No. 2 pool standard solution (General rule first method); in case of color development, it shall not be deeper in comparison with yellow or yellow-green standard colorimetric solution No. 1 (General rule 0901 method 1). (For injection)
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing about 0.4mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the chromatographic conditions under the content determination item, 20 u1 of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 2 times of the retention time of the main peak. If there are impurity peaks in the chromatogram of the test solution, the peak area of a single impurity shall not be greater than 0.5 times (0.25%) of the main peak area of the control solution, the sum of each impurity peak area shall not be greater than 2 times (1.0%) of the main peak area of the control solution.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:57:36
rtca - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
A cation exchange resin in the hydrogen form of a sulfonated crosslinked styrene-divinyl copolymer was used as a filler; Water (adjusted to pH 2.5±0.1 with dilute sulfuric acid) was used as a mobile phase; And the detection wavelength was 207nm. The number of theoretical plates is not less than 2000 based on the ribavirin peak.
assay
take this product, precision weighing, add mobile phase to dissolve and dilute to make a solution containing about 50ug per 1 ml, as a test solution, A 20ul injection liquid chromatograph was used to record the chromatogram. An appropriate amount of ribavirin reference was taken and determined by the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:57:37
rtca - Category
Authoritative Data Verified Data
antiviral drugs.
Last Update：2022-01-01 11:57:37
rtca - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:57:37
rtca - Ribavirin oral solution
Authoritative Data Verified Data
This product contains ribavirin (C8H12N405) should be the label amount of 90.0% ~ 110.0%.
trait
This product is colorless to light yellow liquid; Sweet.
identification
This product was taken, and the same results were shown according to the tests of (1) and (2) under the item of ribavirin.
examination
- the pH value should be 4.0 to 6.0 (General 0631).
- the color of this product, compared with the yellow No. 4 standard colorimetric liquid (General Principles 0901 first method), should not be deeper.
- others should comply with the relevant provisions under the item of oral solution (General rule 0123).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Water as mobile phase; Detection wavelength of 207nm. The number of theoretical plates is not less than 2500 based on the ribavirin peak.
- determination of precision: take an appropriate amount of this product (about 150mg equivalent to ribavirin) and quantitatively dilute it with water to prepare a solution containing 30ug ribavirin per 1 ml as a test solution, 20 u1 was accurately measured, and human liquid chromatography was used to record the chromatogram. An appropriate amount of ribavirin reference was taken, and the same method was used for determination. The peak area was calculated according to the external standard method.
category
Same as ribavirin.
specification
(l)5ml:0.15g (2)10ml:0.3g
storage
sealed storage.
Last Update：2022-01-01 11:57:38
rtca - Ribavirin tablets
Authoritative Data Verified Data
This product contains ribavirin (C8H12N4O5) should be 90.0% to 110.0% of the label.
trait
This product is white or off-white.
identification
take an appropriate amount of fine powder of this product (about 0.lg of ribavirin), add water 20ml, grind, filter, take filtrate, according to the identification under ribavirin (1), (2) one trial showed the same response.
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about equivalent to ribavirin lOOmg), add mobile phase, shake to dissolve ribavirin and quantitatively dilute to prepare a solution containing about 50ug ribavirin per 1 ml, shake well, filter, and take the continued filtrate as the test solution, the assay was performed according to the method under ribavirin.
category
Same as ribavirin.
specification
(l)20mg (2)50mg (3)100mg (4)200mg
storage
sealed storage.
Last Update：2022-01-01 11:57:38
rtca - Ribavirin Dispersible Tablets
Authoritative Data Verified Data
This product contains ribavirin (C8H12N4O5) should be 90.0% to 110.0% of the label.
trait
This product is white or off-white.
identification
- take an appropriate amount of fine powder of this product (about 0.lg of ribavirin), add 10ml of water, grind, filter, add 5ml of sodium hydroxide solution to the filtrate, and heat to boiling, ammonia odor will occur, can make the wet red litmus test paper blue.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about equivalent to ribavirin lOOmg), the mobile phase was added to dissolve and quantitatively dilute to prepare a solution containing 50ug of ribavirin per 1 ml, and the solution was shaken, filtered, and the filtrate was taken as a test solution and measured according to the method of ribavirin.
category
Same as ribavirin.
specification
(l)50mg (2)100mg (3)200mg
storage
sealed and stored in a cool and dry place.
Last Update：2022-01-01 11:57:39
rtca - Ribavirin Buccal Tablets
Authoritative Data Verified Data
This product contains ribavirin (C8H12N4O5) should be 90.0% to 110.0% of the label.
trait
This product is light yellow; Fragrance; Sweet.
identification
take an appropriate amount of fine powder of this product (about 0.lg of ribavirin), add water 20ml, grind, filter, take filtrate, according to the identification under ribavirin (1), (2) the same results were seen in one trial.
examination
should be in accordance with the relevant provisions under The tablet item (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about equivalent to ribavirin lOOmg), add mobile phase, shake to dissolve ribavirin and quantitatively dilute to prepare a solution containing ribavirin in an amount of 50ug per lml, shake well, filter, and take the continued filtrate as a test solution, the assay was performed according to the method under ribavirin.
category
Same as ribavirin.
specification
(l)20mg (2)50mg (3)100mg
storage
sealed storage.
Last Update：2022-01-01 11:57:40
rtca - Ribavirin Injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of ribavirin. Ribavirin (C8H12N405) should be included between 90.0% and 110.0% of the label amount.
trait
This product is a clear colorless liquid.
identification
This product was taken, and the same results were shown according to the tests of (1) and (2) under the item of ribavirin.
examination
- the pH value should be 4.0 to 6.0 (General 0631).
- relevant substances take this product, according to ribavirin under the method of inspection, should comply with the provisions.
- the bacterial endotoxin of this product shall be taken and checked according to law (General rule 1143). The amount of endotoxin contained in ribavirin per 1 mg shall be less than 0.15EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
an appropriate amount of the product was quantitatively diluted with the mobile phase to prepare a solution containing about 50ug of ribavirin per 1 ml, which was used as a test solution and measured according to the method of ribavirin.
category
Same as ribavirin.
specification
(l ) lml:lOOmg (2)2ml:lOOmg (3)2ml:200mg (4)2ml:250mg (5)5ml:250mg (6)5ml:500mg
storage
sealed storage.
Last Update：2022-01-01 11:57:40
rtca - Ribavirin Capsules
Authoritative Data Verified Data
This product contains ribavirin (C8H12N405) should be the label amount of 90.0% ~ 110.0%.
trait
The content of this product is white or white particles or powder.
identification
an appropriate amount of the contents of the product (about 0.lg of ribavirin) was taken, and the same results were obtained according to the identification tests (1) and (2) under ribavirin.
examination
should comply with the relevant provisions under the capsule (General rule 0103).
Content determination
take the contents under the item of difference in loading amount, mix evenly, weigh the appropriate amount accurately (about 100mg equivalent to ribavirin), the mobile phase was added to dissolve and quantitatively dilute to prepare a solution containing 50ug of ribavirin per 1 ml, and the solution was shaken, filtered, and the filtrate was taken as the test solution, and the determination was carried out according to the method of ribavirin.
category
Same as ribavirin.
specification
(1)0.lg (2)0.15g
storage
sealed storage.
Last Update：2022-01-01 11:57:41
rtca - Ribavirin Granules
Authoritative Data Verified Data
This product contains ribavirin (C8H12N405) should be the label amount of 90.0% ~ 110.0%.
trait
This product is white or white soluble particles.
identification
take an appropriate amount of this product (about 0.lg equivalent to ribavirin), add 20ml of water, grind, filter, take the filtrate, according to the identification (1), (2) test under ribavirin, the same results are shown.
examination
- weight loss on drying this product shall be dried at 105°C to constant weight, and the weight loss shall not exceed 2.0% (General rule 0831).
- others should comply with the relevant provisions under The granule (General Principle 0104).
Content determination
appropriate amount of contents under the item of difference in loading amount, mix evenly, weigh the appropriate amount accurately (about equivalent to ribavirin lOOmg), A solution containing 50ug of ribavirin per 1 ml was prepared by grinding with a mobile phase to dissolve and quantitatively dilute, filtered, and the filtrate was taken as a test solution. The assay was performed according to the method under ribavirin.
category
Same as ribavirin.
specification
(l)50mg (2)0.lg (3)0.15g
storage
sealed and stored in a dry place.
Last Update：2022-01-01 11:57:42
rtca - Ribavirin Eye Drops
Authoritative Data Verified Data
- This product contains ribavirin (C8H12N405) should be the label amount of 90.0% ~ 110.0%.
- an appropriate amount of bacteriostatic agent can be added to this product.
trait
This product is a clear colorless liquid.
identification
This product was taken, and the same results were shown according to the tests of (1) and (2) under the item of ribavirin.
examination
- the pH value should be 5.0 to 7.0 (General 0631).
- The osmolality should be 250 to 0632 mosmol/kg (general).
- others shall comply with the relevant provisions under Ophthalmic Preparations (General rule 0105).
Content determination
take an appropriate amount of this product and quantitatively dilute it with mobile phase to prepare a solution containing 50ug ribavirin per lml, which is used as a test solution according to the chromatographic conditions under the item of ribavirin content determination, the degree of separation between ribavirin peak and bacteriostatic peak shall be in accordance with regulations, and shall be determined according to the method under ribavirin.
category
Same as ribavirin.
specification
(1)0.5ml:0.5mg (2)8ml:8mg (3) 10ml:1Omg (4) 10ml:50mg
storage
sealed and stored in a cool place.
Last Update：2022-01-01 11:57:42
rtca - Ribavirin Nasal Drops
Authoritative Data Verified Data
- This product contains ribavirin (C8H12N405) should be the label amount of 90.0% ~ 110.0%.
- an appropriate amount of bacteriostatic agent can be added to this product.
trait
This product is a clear colorless liquid.
identification
take this product, according to ribavirin under the identification of (1), (2) test, showed the same results.
examination
- the pH value should be 4.5 to 6.5 (General 0631).
- The osmolality should be 270 to 330 mosmol/kg (General 0632).
- others should comply with the relevant provisions under nasal preparations (General rule 0106).
Content determination
take an appropriate amount of this product and quantitatively dilute it with mobile phase to prepare a solution containing 50ug ribavirin per lml, which is used as a test solution according to the chromatographic conditions under the item of ribavirin content determination, the degree of separation between ribavirin peak and bacteriostatic peak shall be in accordance with regulations, and shall be determined according to the method under ribavirin.
category
Same as ribavirin.
specification
(l)8ml:40mg (2)10ml:50mg
storage
sealed and stored in a cool place.
Last Update：2022-01-01 11:57:43
rtca - Ribavirin and Glucose Injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of ribavirin and dextrose containing ribavirin (C8H12N4O5) in the range of 90.0% to 110.0% of the label amount and glucose (C6H1206 • H20) in the range of 95.0% to 105.0% of the label amount.
trait
This product is a clear colorless liquid.
identification
- The product was taken and the same results were shown according to the identification tests (1) and (2) under ribavirin.
- take this product and slowly drop the warm alkaline copper tartrate test solution, which will cause red precipitation of cuprous oxide.
examination
- the pH value should be 4.0 to 6.0 (General 0631).
- S-hydroxymethyl Bran precision take the right amount of this product (about equivalent to glucose O.lg), 50ml flask, diluted with water to the scale, shake, UV-visible spectrophotometry (General 0401), measured at the wavelength of 284nm, absorbance should not be greater than 0.25.
- relevant substances take this product, according to ribavirin under the method of inspection, should comply with the provisions.
- take an appropriate amount of precious metal (about 3g of glucose), evaporate to about 20ml if necessary, let it cool, and add 2ml of acetate buffer (pH 3.5), inspection by law (General Principles 0821, law I), the content of heavy metals must not exceed 5 parts per million of the amount of glucose marked.
- The osmolality should be 260 to 0632 mosmol/kg (general).
- bacterial endotoxin this product, according to the law to check (General 1143), the amount of endotoxin per lml should be less than 0.50EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- ribavirin an appropriate amount of this product was quantitatively diluted with mobile phase to prepare a solution containing about 50ug of ribavirin per 1 ml, which was used as a test solution and measured according to the method under ribavirin.
- glucose precision measure 2ml of this product (about 0.lg of glucose), put it in an iodine bottle, and add 25ml of Iodine titration solution (0.05mol/L), sodium hydroxide titration solution was added dropwise while shaking (0.lmol/LMOml, placed in the dark for 30 minutes, add dilute sulfuric acid 4ml, with sodium thiosulfate titration solution (0.1 mol/L) titration, near the end point, add 2ml of starch indicator solution, continue titration to blue disappeared, and the titration result is corrected by blank test. Each 1 ml of the iodometric titration solution (0.05mol/L) corresponds to 9.909mg of glucose (C6H12O6 · H20).
category
Same as ribavirin.
specification
- 100ml: ribavirin 0.lg with glucose 5G
- 100ml: ribavirin 0.2g and glucose 5G
- 100ml: ribavirin 0.5g and glucose 5G
- 250ml: ribavirin 0.25g with glucose 12.5g
- 250ml: ribavirin 0.5g with glucose 12.5g
- 500ml: ribavirin 0.5g and glucose 25g
storage
shade, close, and store in a cool place.
Last Update：2022-01-01 11:57:44
rtca - Ribavirin and sodium chloride injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of ribavirin and sodium chloride, containing ribavirin (C8H12N405) should be 90.0% ~ 110.0% of label amount, containing sodium chloride (NaCl) should be 95.0% ~ 105.0% of label amount.
trait
This product is a clear colorless liquid.
identification
- The product was taken and the same results were shown according to the identification tests (1) and (2) under ribavirin.
- This product shows the reaction of sodium salt identification (1) and chloride identification (1) (General rule 0301).
examination
- the pH value should be 4.0 to 6.0 (General 0631).
- relevant substances take this product, according to ribavirin under the method of inspection, should comply with the provisions.
- take 50ml of heavy metal, evaporate to about 20ml, let it cool, add 2ml of acetate buffer (pH3.5) and an appropriate amount of water to make 25ml, and check it according to law (General rule 0821, Law 1), heavy metals should not exceed three million.
- The osmolality should be 260 to 0632 mosmol/kg (general).
- bacterial endotoxin this product, according to the law to check (General 1143), the amount of endotoxin per lml should be less than 0.50EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
ribavirin an appropriate amount of the product was accurately measured, and quantitatively diluted with the mobile phase to prepare a solution containing about 50ug of ribavirin per 1 ml, which was used as a test solution and measured according to the method under ribavirin. Sodium nitride precision take 10ml of this product, add water 40ml, add dextrin solution (1-50)5ml, calcium carbonate 0.lg and fluorescent yellow indicator solution 8 drops, with silver nitrate titration solution (O.lmol /L) titration. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 5.844mg of sodium chloride.
category
Same as ribavirin.
specification
- nooml: ribavirin 0.2g and sodium chloride 0.9g
- 100mi: ribavirin 0.5g with sodium chloride 0.8g
- 100ml: ribavirin 0.5g and sodium chloride 0.9g
- 250ml: ribavirin 0.5g with sodium chloride 1.95g
- 250ml: ribavirin 0.5g with sodium chloride 2.125G
- 250ml: ribavirin 0.5g with sodium chloride 2.25g
storage
shade, close, and store in a cool place.
Last Update：2022-01-01 11:57:45
rtca - Ribavirin for Iniection
Authoritative Data Verified Data
This product is sterile lyophilized with ribavirin and suitable excipients. The content of ribavirin (C8H12N405) shall be between 90.0% and 110.0% of the labeled amount, calculated as the average loading.
trait
This product is white or white loose lumps.
identification
This product was taken, and the same results were shown according to the tests of (1) and (2) under the item of ribavirin.
examination
- acidity take appropriate amount of this product (about equivalent to ribavirin l. (Og), add 50ml of water to dissolve, add 0.2ml of saturated potassium chloride solution, shake well, and measure according to law (General rule 0631), the pH value should be 4.0~7.0.
- clarity and color of the solution take this product, add water to dissolve and dilute to make a solution containing ribavirin 50mg per 1 ml, the solution should be clear and colorless; If it is turbid, it shall not be more concentrated than that of turbidity standard liquid No. 1 (General rule 0902 method 1); In case of color development, it shall not be deeper than that of yellow or yellow-green standard colorimetric liquid No. 1 (General rule 0901 method 1).
- relevant substances take this product, according to ribavirin under the method of inspection, should comply with the provisions.
- weight loss on drying this product shall be dried at 105°C to constant weight, and the weight loss shall not exceed 5.0% (General rule 0831).
- the bacterial endotoxin of this product shall be taken and checked according to law (General rule 1143). The amount of endotoxin contained in ribavirin per 1 mg shall be less than 0.15EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take the appropriate amount of contents under the item of difference in loading amount, mix evenly, weigh the appropriate amount accurately (equivalent to ribavirin 100mg), the mobile phase was added to dissolve and quantitatively dilute to prepare a solution containing 50ug of ribavirin per 1 ml, which was used as a test solution and measured according to the method under ribavirin.
category
Same as ribavirin.
specification
(1)0.lg (2)0.25g (3)0.5g
storage
sealed and stored in a cool place.
Last Update：2022-01-01 11:57:46
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Product Name: ribavirin Request for quotation
CAS: 36791-04-5
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info@tnjchem.com
Mobile: 0086 189 4982 3763
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Product List: View Catalog
CAS: 36791-04-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: RTCA Visit Supplier Webpage Request for quotationCAS: 36791-04-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Raw Materials for rtca