silybummarianum(linn.)gaertn.,extract
Silybum marianum, ext.
CAS: 84604-20-6
Molecular Formula: C25H22O10
silybummarianum(linn.)gaertn.,extract - Names and Identifiers
| Name | Silybum marianum, ext. |
| Synonyms | Milk Thistle UNII-822I9LEJ7S Einecs 283-298-7 Milk Thistle Extract Lady's thistle extract Silybum marianum, ext. Silybum marianum extract Extract of lady'S thistle Extract of lady's thistle Silybum marianum (L.)Gaerth silybummarianum(linn.)gaertn.,extract POWDERED MILK THISTLE EXTRACT (250 MG) silybummarianumextract,lady'sthistleextract Lady's thistle (Silybum marianum L. Gaertner) |
| CAS | 84604-20-6 |
| EINECS | 283-298-7 |
silybummarianum(linn.)gaertn.,extract - Physico-chemical Properties
| Molecular Formula | C25H22O10 |
| Molar Mass | 482.43618 |
| Density | 1.144 |
silybummarianum(linn.)gaertn.,extract - Risk and Safety
| HS Code | 2932996560 |
silybummarianum(linn.)gaertn.,extract - Reference Information
| description of properties | light yellow powder or crystal, with special smell, easily soluble in acetone, ethyl acetate, ethanol and methanol, hardly soluble in chloroform, almost insoluble in water, mainly containing a flavonoid complex called silymarin (C25H22O10). This substance is the main source of medicinal value of this plant. Silybin has the strongest activity and is largely responsible for the properties of silymarin. Milk Thistle extract has obvious protection and stabilization of liver cells, and is used to treat acute and chronic hepatitis, liver cirrhosis, liver poisoning and other diseases. The symptoms and liver function of hepatitis patients are significantly improved. It has the function of stabilizing cells and intracellular biofilm. It has the effect of anti-ejaculation. Can inhibit peritonitis caused by formaldehyde. |
| plant source | milk thistle extract is refined from the whole grass and achenes of the Compositae plant milk thistle Silybum marianum (L.)Gaerth. Milk thistle is an annual or biennial herb, native to southern Europe and North Africa. It has been cultivated and used for thousands of years in Europe and Africa. It began to be tested in China in the 80s and later planted in Shaanxi, Hebei, Jiangsu, Northeast and other places. Shaanxi is the best product. It is a folk medicinal plant with a height of 1.2-3m and many branches, the leaves are large pinnate or oblong-lanceolate, with a base of clasping stems, leathery, shiny, wavy leaf surface with milky white cloud spots, leaf margins pinnately and deeply divided, with sharp spikes, head inflorescence, diameter 2-5-7cm, terminal or axillary, tubular flowers; involucre is multi-lobed, hard, sharp as thorns, achene oval, brown or dark brown, and white crown hairs. From the beginning of May to the beginning of July, a head inflorescence takes 25-30 days from flowering to fruit ripening. When the bracts are yellow and curled inward into a tube and the top crown is slightly opened, the mark seeds have matured and are generally harvested 3-5 times. |
| usage history | the usage history of milk thistle can be traced back to more than 2,000 years ago. The famous pharmacist in the seventeenth century, Nicholas. Copep cited its open "blocking" effect on the liver and spleen and recommended it for the treatment of jaundice. |
| sexual taste meridian differentiation | sexual taste meridian differentiation of milk thistle extract: cold in nature and bitter in taste. Return to liver and gallbladder meridian. |
| function and action | milk thistle extract can protect liver cells by hindering the entry of harmful toxins and helping to remove these substances from liver cells. Like other bioflavonoids, silymarin is a powerful antioxidant. Silymarin also shows the effect of regenerating damaged hepatocytes. Recent studies have shown that silymarin has the ability to prevent fibrosis, a class of patients with inflammatory liver conditions secondary to diseases such as alcoholism and hepatitis, which may eventually develop into a process of cirrhosis. The most commonly used use of milk thistle extract is to neutralize the harmful effects of alcohol on the liver. Double-blind trials have shown that they can help the liver of people who quit drinking to return to a healthy state. Some experiments suggest that milk thistle extract can improve the quality of life and even give hope to hepatitis patients. Milk thistle can change the composition of bile, thereby potentially reducing the risk of gallstones. However, this efficacy still needs to be confirmed by human clinical trials. Milk Thistle extract has been shown to protect the liver from the potential harm of drugs used to treat schizophrenia and other psychiatric disorders. However, a trial found that it did not protect the liver from the potentially harmful effects of the drug Corknix (1.2.3.4-tetrahydro-9-aminoacridine hydrochloride) used to treat early-stage Alzheimer's disease. |
| application | milk thistle extract can be applied to the following fields: medicine, solid beverage, health care products, tableted candy, cosmetics, etc. |
| when using dose | for liver diseases and liver function injuries, the study believes that silymarin with 80% silymarin content should be extracted from silymarin milk thistle by taking 420-600mg daily. According to research and clinical experience, the situation should improve within eight to twelve weeks. For patients with chronic liver disease, milk thistle extract may be considered as a long-term treatment. |
| reference quality standard | appearance light brown yellow powder screening test 80 mesh sieve humidity <5.0% silymarin> 80% extraction solvent alcohol and water transport carrier ash <5.0% heavy metal <10 mg/kg arsenic (As2O3) <2 mg/kg aflatoxin <0.2ppb total number of bacteria <1000/g Escherichia coli must not be detected mold + yeast <100/g salmonella must not be detected |
| side effects | milk thistle extract does not have any side effects in essence, and can be used by most people, including pregnant and nursing women. In fact, it is recommended to treat pruritus caused by insufficient gallbladder function during pregnancy. Because silymarin stimulates liver and gallbladder activity, it may have a short-term mild diarrhea effect on some people. The effect usually disappears within 2 to 3 days. |
| preservation method | milk thistle extract should be placed in a cool and dry place, away from light and high temperature. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov provided (external link) |
Last Update：2024-04-09 21:31:57
