sulbone
Thiothiamine
CAS: 299-35-4
Molecular Formula: C12H16N4OS2
sulbone - Names and Identifiers
sulbone - Physico-chemical Properties
| Molecular Formula | C12H16N4OS2 |
| Molar Mass | 296.41 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 238-239 °C |
| Boling Point | 509.6±60.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Very Slightly, Heated) |
| Appearance | Solid |
| Color | Pale Beige to Light Brown |
| pKa | 14.72±0.10(Predicted) |
| Storage Condition | Refrigerator |
| Physical and Chemical Properties | Crystal. The melting point of 239 deg C, its hydrochloride decomposition at 245 deg C. |
| Use | 4-amino-2-methyl-5-acetamidomethylpyrimidine is hydrolyzed with 16% sodium hydroxide at 105-118 °c for 2-3H to produce 4-amino-2-methyl-5-aminomethylpyrimidine. After cooling, the solution was cooled to 18 ° C by adding mercerol ammonium chloride at 23-25 ° C., then carbon disulfide was added and reacted at 33-35 ° C. For 1.5h. Then cool to 24 °c, add gamma-chlorogamma-Acetyl acetate, react at 35-45 °c for 4H, cool to below 35 °c, filter, wash with water, filter dry, 3-(2-methyl -4-amino -5-pyrimidinomethyl) aminoxanthogen-3-acetylpropanol acetate is obtained. It was put into water, hydrochloric acid was added, heated with stirring, and hydrolyzed at 75-80 °c for 10min. Citric acid, activated carbon and water were added and heated to 55-60 °c for 15min to decolorize. Pressure filtration was performed, and the filtrate was neutralized to pH7-7.5 at 40-55 °c with 20% sodium hydroxide solution. The filter cake was filtered, washed with water, and filtered to obtain thiothiamine. The yield was about 80%. |
sulbone - Reference
| Reference Show more | 1. Zhang Qiao, Chen Chunxi, Wu Tianbao. Study on optimization of fermentation conditions of hawthorn juice by Hericium erinaceus [J]. China brewing 2018 37(12):171-174. |
sulbone - Reference Information
| Use | for the pharmaceutical industry, vitamin B1 intermediates. used in pharmaceutical industry, is vitamin B1 intermediate |
| production method | 4-amino-2-methyl-5-acetamido-methylpyrimidine hydrolyzed with 16% sodium hydroxide at 105-118 ℃ for 2-3H to produce 4-amino -2-methyl-5-aminomethylpyrimidine. After cooling, the solution was cooled to 18 ° C by adding mercerol ammonium chloride at 23-25 ° C., then carbon disulfide was added and reacted at 33-35 ° C. For 1.5h. Then cool to 24 °c, add gamma-chlorogamma-Acetyl acetate, react at 35-45 °c for 4H, cool to below 35 °c, filter, wash with water, filter dry, 3-(2-methyl -4-amino -5-pyrimidinomethyl) aminoxanthogen-3-acetylpropanol acetate is obtained. It was put into water, hydrochloric acid was added, heated with stirring, and hydrolyzed at 75-80 °c for 10min. Citric acid, activated carbon and water were added and heated to 55-60 °c for 15min to decolorize. Pressure filtration was performed, and the filtrate was neutralized to pH7-7.5 at 40-55 °c with 20% sodium hydroxide solution. The filter cake was filtered, washed with water, and filtered to obtain thiothiamine. The yield was about 80%. |
Last Update：2024-04-09 20:52:54
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Product Name: Thiamine Impurity 5 (Thiamine EP Impurity E) Visit Supplier Webpage Request for quotationCAS: 299-35-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple Specifications
Product Name: Thiothiamine Visit Supplier Webpage Request for quotationCAS: 299-35-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Thiothiamine Request for quotation
CAS: 299-35-4
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Email: 44611356@qq.com
Mobile: 18769063538
QQ: 44611356Send QQ message
CAS: 299-35-4
Tel: 086-18769063538
Email: 44611356@qq.com
Mobile: 18769063538
QQ: 44611356
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