t-Boc-N-Amido-PEG2-Propargyl
tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate
CAS: 869310-84-9
Molecular Formula: C12H21NO4
t-Boc-N-Amido-PEG2-Propargyl - Names and Identifiers
t-Boc-N-Amido-PEG2-Propargyl - Physico-chemical Properties
| Molecular Formula | C12H21NO4 |
| Molar Mass | 243.3 |
| Physical and Chemical Properties | Bioactive Propargyl-PEG2-NHBoc is a degradable (cleavable) ADC linker used in the synthesis of antibody-coupled drugs (ADCs). Propargyl-PEG2-NHBoc is a PROTAC linker and belongs to the PEG class. Propargyl-PEG2-NHBoc can be used to synthesize a series of PROTAC molecules. |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
t-Boc-N-Amido-PEG2-Propargyl - Uses and synthesis methods
Target
CleavablePEGsAlkyl/ether
in vitro studies
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Last Update：2024-04-10 22:29:15
t-Boc-N-Amido-PEG2-Propargyl - Introduction
tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate is an organic compound. The following is an introduction to some of its properties, uses, formulation and safety information:
Nature:
- tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate is a colorless liquid with an odor similar to acetate.
-It is soluble in organic solvents such as alcohols and ethers.
Use:
- tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate is usually used as a synthetic intermediate to prepare other chemical compounds.
-It can be used as acylation reagent and cyclization reagent in chemical synthesis.
Preparation Method:
-The preparation method of tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate generally involves chemical reactions and synthetic steps. The specific preparation method may vary depending on the purpose of the study.
Safety Information:
- tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate may be irritating. In operation and use, should follow the correct safety laboratory and chemical use guidelines.
-In any case, avoid direct contact with skin and eyes, and avoid inhaling its vapor or dust.
-It should be stored in a dry, cool, well-ventilated place, and away from combustibles and heat sources.
Please note that this is only an overview, and specific chemical and safety information should be studied and understood in a laboratory or professional environment.
Nature:
- tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate is a colorless liquid with an odor similar to acetate.
-It is soluble in organic solvents such as alcohols and ethers.
Use:
- tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate is usually used as a synthetic intermediate to prepare other chemical compounds.
-It can be used as acylation reagent and cyclization reagent in chemical synthesis.
Preparation Method:
-The preparation method of tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate generally involves chemical reactions and synthetic steps. The specific preparation method may vary depending on the purpose of the study.
Safety Information:
- tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate may be irritating. In operation and use, should follow the correct safety laboratory and chemical use guidelines.
-In any case, avoid direct contact with skin and eyes, and avoid inhaling its vapor or dust.
-It should be stored in a dry, cool, well-ventilated place, and away from combustibles and heat sources.
Please note that this is only an overview, and specific chemical and safety information should be studied and understood in a laboratory or professional environment.
Last Update：2024-04-09 19:05:03
