t-Boc-N-Amido-PEG3-propargyl
t-Boc-N-Amido-PEG3-propargyl
CAS: 1333880-60-6
Molecular Formula: C14H25NO5
t-Boc-N-Amido-PEG3-propargyl - Names and Identifiers
t-Boc-N-Amido-PEG3-propargyl - Physico-chemical Properties
| Molecular Formula | C14H25NO5 |
| Molar Mass | 287.35 |
| Density | 1.045±0.06 g/cm3(Predicted) |
| Boling Point | 386.4±32.0 °C(Predicted) |
| pKa | 12.22±0.46(Predicted) |
t-Boc-N-Amido-PEG3-propargyl - Upstream Downstream Industry
t-Boc-N-Amido-PEG3-propargyl - Introduction
t-Boc-N-Amido-PEG3-propargyl(t-Boc-N-Amido-PEG3-propargyl) is a chemical reagent that has some of the following properties and uses:
Nature:
-Appearance: colorless or light yellow liquid
-molecular formula: C22H39NO8
-Molecular weight: 453.57g/mol
-Melting Point: N/A
-Boiling point: 400 ° C (desorption)
-Solubility: Soluble in regular organic solvents (such as methanol, ethanol, dimethyl sulfoxide, etc.), insoluble in water.
Use:
-As a protecting group in polypeptide synthesis and chemical biology, it is used to protect the α-amino group of amino acids or peptides.
-Used as a propyne functionalizing reagent in the synthesis of peptides, proteins and antibody drugs.
-In chemical reactions, it can be used as a starting reagent for mounting the PEG chain to improve the solubility and stability of biologically active molecules.
Method:
t-Boc-N-Amido-PEG3-propargyl synthesis methods are more diverse, but a common synthetic route is as follows:
1. Esterification of N-tert-butoxycarbonylidenetrimethylalanine tert-butyl ester with activated polyethylene glycol (PEG) to form a hydrophilic segment of PEG protected by N-acyl.
2. Through the nucleophilic substitution reaction, the tert-butoxycarbonyl subunit is converted into the tert-butoxycarbonyl (Boc) group of the protected amino acid.
3. The propyne functional group is introduced into the hydrophilic segment of PEG. The method can be nucleophilic substitution reaction or electrophilic substitution reaction.
4. Finally, the t-Boc-N-Amido-PEG3-propargyl is obtained through appropriate separation and purification processes.
Safety Information:
t-Boc-N-Amido-PEG3-propargyl are chemical reagents that need to be used and stored correctly to ensure safety. Observe the following safety measures:
-Avoid direct contact with skin, eyes and mucous membranes. Wear appropriate personal protective equipment such as lab gloves and goggles when using.
-During use and storage, Please maintain a well-ventilated laboratory environment.
-Avoid inhaling gases, vapors, spray or dust. If breathing discomfort occurs, discontinue use and seek medical help.
-When storing, keep it in an airtight container, away from fire sources and combustible materials.
-Follow local waste disposal regulations when handling and discarding.
Nature:
-Appearance: colorless or light yellow liquid
-molecular formula: C22H39NO8
-Molecular weight: 453.57g/mol
-Melting Point: N/A
-Boiling point: 400 ° C (desorption)
-Solubility: Soluble in regular organic solvents (such as methanol, ethanol, dimethyl sulfoxide, etc.), insoluble in water.
Use:
-As a protecting group in polypeptide synthesis and chemical biology, it is used to protect the α-amino group of amino acids or peptides.
-Used as a propyne functionalizing reagent in the synthesis of peptides, proteins and antibody drugs.
-In chemical reactions, it can be used as a starting reagent for mounting the PEG chain to improve the solubility and stability of biologically active molecules.
Method:
t-Boc-N-Amido-PEG3-propargyl synthesis methods are more diverse, but a common synthetic route is as follows:
1. Esterification of N-tert-butoxycarbonylidenetrimethylalanine tert-butyl ester with activated polyethylene glycol (PEG) to form a hydrophilic segment of PEG protected by N-acyl.
2. Through the nucleophilic substitution reaction, the tert-butoxycarbonyl subunit is converted into the tert-butoxycarbonyl (Boc) group of the protected amino acid.
3. The propyne functional group is introduced into the hydrophilic segment of PEG. The method can be nucleophilic substitution reaction or electrophilic substitution reaction.
4. Finally, the t-Boc-N-Amido-PEG3-propargyl is obtained through appropriate separation and purification processes.
Safety Information:
t-Boc-N-Amido-PEG3-propargyl are chemical reagents that need to be used and stored correctly to ensure safety. Observe the following safety measures:
-Avoid direct contact with skin, eyes and mucous membranes. Wear appropriate personal protective equipment such as lab gloves and goggles when using.
-During use and storage, Please maintain a well-ventilated laboratory environment.
-Avoid inhaling gases, vapors, spray or dust. If breathing discomfort occurs, discontinue use and seek medical help.
-When storing, keep it in an airtight container, away from fire sources and combustible materials.
-Follow local waste disposal regulations when handling and discarding.
Last Update：2024-04-09 21:00:56
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Raw Materials for t-Boc-N-Amido-PEG3-propargyl
5,8,11-Trioxa-12-thia-2-azatridecanoic acid, 1,1-dimethylethyl ester, 12,12-dioxide
2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL
2-(2-BOC-AMINOETHOXY)ETHANOL
(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
2-[2-(2-AZIDOETHOXY)ETHOXY]ETHANOL
2-(2-BOC-AMINOETHOXY)ETHANOL
(2-[2-(2-HYDROXY-ETHOXY)-ETHOXY]-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER