tBuBrettPhos

tBuBrettPhos - Names and Identifiers

Name	2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl,t-butylBrettPhos
Synonyms	tBuBrettPhos t-butylBrettPhos tertButylBrettPhos tert-ButylBrettPhos -3,6-dimethoxybiphenyL 2-(Di-tert-butylphosphino)-2',4',6'-triisopropyl-3,6-diMethoxybiphenyl 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-3,6-diMethoxy-1,1'-biphenyl (t-BuBrettPhos) 2-(Di-t-butylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl,t-butylBrettPhos
CAS	1160861-53-9
InChIKey	REWLCYPYZCHYSS-UHFFFAOYSA-N

tBuBrettPhos - Physico-chemical Properties

Molecular Formula	C31H49O2P
Molar Mass	484.69
Melting Point	166-170°C
Boling Point	534.9±50.0 °C(Predicted)
Appearance	crystal
Color	white
Storage Condition	Room Temprature
Use	Use 2- (di-tert-butylphosphine)-3, 6-dimethoxy-2 ',4',6 '-triisopropyl-1, 1'-biphenyl belongs to a 2-dialkylphosphine -3, 6-dimethoxy-2 ',4',6 '-triisopropyl-1, 1'-biphenyl is an important class of organic phosphine ligands, complexing with transition metals can be used as catalysts for organic coupling reactions, and has a very wide range of applications in the synthesis of natural products, drugs, functional materials, liquid crystal molecules and bioactive compounds.

tBuBrettPhos - Risk and Safety

WGK Germany

tBuBrettPhos - Nature

melting point	166-170°C
boiling point	534.9±50.0 °C(Predicted)
morphology	crystal
color	white
InChIKey	REWLCYPYZCHYSS-UHFFFAOYSA-N

Last Update：2024-04-10 22:29:15

tBuBrettPhos - Introduction

2-(Di-t-butylphosphino)-3,6-dimethoxy-2 '-4'-6 '-tri-i-propyl-1,1'-biphenyl,t-butylBrettPhos, often abbreviated as DTBM-TPP.

Nature:
DTBM-TPP is an organic compound whose molecular formula is C38H54O2P2. It is a colorless crystalline solid. DTBM-TPP has high thermal stability and can exist stably at high temperatures. It is soluble in organic solvents but insoluble in water.

Use:
DTBM-TPP are mainly used as ligands or catalysts in chemical research to catalyze the synthesis of benzimidazolones and organic synthesis reactions. It can also be used as a light-emitting layer material for organic light-emitting diodes (OLEDs) with excellent fluorescent properties.

Preparation Method:
The method for preparing DTBM-TPP can be obtained by reacting phenylphosphoric acid with dimethoxybromobenzene in the presence of alkaline conditions, and then heating to obtain the target product. Specific synthetic routes may vary depending on experimental conditions and requirements.

Safety Information:
There is limited safety data on DTBM-TPP, so caution is required during handling and transportation. Avoid contact with skin and eyes and prevent inhalation or ingestion. Appropriate personal protective equipment, such as lab gloves and goggles, is recommended for use in a laboratory environment. If you have any health and safety issues, please follow the guidance of the laboratory safety operation and relevant regulations.

Last Update：2024-04-10 22:29:15

tBuBrettPhos - Uses and synthesis methods

use

2- (di-tert-butylphosphine)-3,6-dimethoxy -2 ',4',6 '-triisopropyl -1,1'-biphenyl belongs to a 2-dialkylphosphine -3,6-dimethoxy -2 ',4',6 '-triisopropyl -1,1'-biphenyl, which is an important organic phosphine ligand, it can be used as a catalyst for organic coupling reaction after complexing with transition metals, and has a very wide range of applications in the synthesis of natural products, drugs, functional materials, liquid crystal molecules and bioactive compounds.

preparation

under the protection of argon, the reaction solvent tetrahydrofuran 0.5L and magnesium metal (26g,1.1mol) are added to the drying reactor, then di-tert-butyl phosphine chloride (180g,1mol) is added at -10~10 ℃ for 2 hours, and then nickel catalyst Ni(acac)2(13g,0.05mol) and 2-bromo -3,6-dimethoxy -2 'are added',4 ',6'-triisopropyl -1,1 '-biphenyl (419g,1mol), then heated to 80 ℃ for 12 hours, then added 500mL of saturated ammonium chloride aqueous solution to quench the reaction, after liquid separation, organic phase concentration to remove solvent, methanol recrystallization to obtain 2-di-tert-butyl phosphine -3,6-dimethoxy -2',4, 90% yield.

Last Update：2024-04-10 22:29:15