Molecular Formula | C16H19ClSi |
Molar Mass | 274.86 |
Density | 1.057g/mLat 25°C(lit.) |
Boling Point | 90°C0.01mm Hg(lit.) |
Flash Point | >230°F |
Water Solubility | reacts |
Solubility | miscible in most organic solvents. |
Vapor Presure | 0.000249mmHg at 25°C |
Appearance | Liquid |
Specific Gravity | 1.074 |
Color | Clear colorless to yellow or slightly brown |
BRN | 644023 |
Storage Condition | Inert atmosphere,2-8°C |
Sensitive | Moisture Sensitive |
Refractive Index | n20/D 1.568(lit.) |
Physical and Chemical Properties | Density 1.057 boiling point 90°C (0.01 mmHg) refractive index 1.5665-1.5685 flash point 149°C water-soluble reactions |
Use | Used as pharmaceutical intermediates and for organic synthesis |
Risk Codes | R14 - Reacts violently with water R34 - Causes burns R37 - Irritating to the respiratory system R29 - Contact with water liberates toxic gas R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S8 - Keep container dry. |
UN IDs | UN 2987 8/PG 2 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 10 |
TSCA | Yes |
HS Code | 29310095 |
Hazard Note | Irritant/Corrosive |
Hazard Class | 8 |
Packing Group | II |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Uses | tert-butyldiphenylchlorosilane is also called silane protective agent. Its function is to replace the active hydrogen in the silane group compound (such as hydroxyl, carboxyl and amino) Hydrogen in the group), to form a stable intermediate; then, the other groups of the intermediate are undergoing certain reactions; after the reaction is over, the silane group is removed through the hydrolysis reaction, regenerate the groups originally protected by silane groups to synthesize certain specific compounds. Due to the high conversion rate of silane protection and deprotection reaction, even quantitative reaction, it is widely used in organic synthesis, especially in drug synthesis. tert-butyl diphenylchlorosilane is used to synthesize p-benzophenyloxazole, which is a compound with antagonistic activity to thromboxane receptors, and can be used to treat circulatory diseases, angina pectoris and stroke. It is used as a pharmaceutical intermediate and used in organic synthesis A kind of silicon-based protective group; used in the synthesis of pharmaceutical intermediates or other polymers. Silanizing reagent, used to protect alcohols and prepare silyl ethers Silicizing agent, used to protect alcohols and prepare silyl ethers |
preparation | adding 200Ml of tetrahydrofuran, 12g of magnesium and 6g of chloropropene (the remaining 40g of chloropropene is added to the 500Ml reaction kettle with snake condenser, electric stirrer, dropping funnel, thermometer and heater, under stirring, slowly heating to initiate the reaction and controlling the reaction temperature to 50~75 ℃, once the reaction is triggered, the heating will be stopped immediately. If the reaction is severe, the reaction kettle will be cooled quickly. After the reaction is stable, the dropping funnel will be opened, and propylene chloride will be dripped into the reaction kettle. After the dripping is completed, the heating will be reduced to room temperature. Then 0.2g of sodium thiocyanate and 0.2g of cuprous chloride catalyst will be added into the reaction kettle. 127g of diphenyldichlorosilane will be added into the dripping funnel, and the dripping will be completed, the materials in the reaction kettle are heated to 90~150 ℃, reacted at a constant temperature for 4~7 hours, the reaction is finished, 100mL of inert solvent toluene is added to the reaction kettle after lowering to room temperature, stirred evenly, the generated liquid is filtered to remove solid salt, the filtrate is distilled, the flux is distilled, and then the solution is distilled under reduced pressure. At 0.09Kpa, the fraction at 200 ℃ is collected to obtain the product tert-butyldiphenylchlorosilane with 98% content. |