tert-butyl (R)-2-cyanopyrrolidine-1-carboxylate

tert-butyl (R)-2-cyanopyrrolidine-1-carboxylate - Names and Identifiers

Name	(R)-1-Boc-2-cyanopyrrolidine
Synonyms	BOC-L-PRO-NITRILE (R)-1-Boc-2-cyanopyrrolidine 1-N-Boc-2-pyrrolidinonitrile (R)-N-BOC-2-PYRROLIDINONITRILE (S)-N-BOC-2-PYRROLIDINONITRILE (S)-(-)-BOC-2-CYANOPYRROLIDINE (S)-1-N-BOC-2-CYANO-PYRROLIDINE (S)-1-N-BOC-2-PYRROLIDINONITRILE (S)-(-)-BOC-2-PYRROLIDINONITRILE tert-butyl 2-cyanopyrrolidine-1-carboxylate (R)-tert-Butyl 2-cyanopyrrolidine-1-carboxylate tert-butyl (R)-2-cyanopyrrolidine-1-carboxylate tert-butyl (2R)-2-cyanopyrrolidine-1-carboxylate (R)-1-(tert-Butoxycarbonyl)-2-pyrrolidinecarbonitrile (S)-2-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Pyrrolidinecarboxylic acid, 2-cyano-, 1,1-dimethylethyl ester, (2R)-
CAS	144688-70-0 228244-20-0
InChI	InChI=1/C10H16N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(12)7-11/h8H,4-6H2,1-3H3/t8-/m1/s1
InChIKey	MDMSZBHMBCNYNO-MRVPVSSYSA-N

tert-butyl (R)-2-cyanopyrrolidine-1-carboxylate - Physico-chemical Properties

Molecular Formula	C10H16N2O2
Molar Mass	196.25
Density	1.08±0.1 g/cm3(Predicted)
Melting Point	32-37℃
Boling Point	307.9±35.0 °C(Predicted)
Flash Point	>110℃
Vapor Presure	0.000703mmHg at 25°C
pKa	-4.97±0.40(Predicted)
Storage Condition	2-8°C
Sensitive	Moisture & Light Sensitive
Refractive Index	1.488
MDL	MFCD06411382
Physical and Chemical Properties	WGK Germany:3

tert-butyl (R)-2-cyanopyrrolidine-1-carboxylate - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany	3
HS Code	29339900

tert-butyl (R)-2-cyanopyrrolidine-1-carboxylate - Introduction

(R)-1-Boc-2-cyanopyrrolidine is an organic compound whose chemical properties mainly include:

1. Structural characteristics: It is a chiral compound with (S)-and (R)-Two enantiomers. The molecule contains Boc protecting group (tert-butoxycarbonyl), cyano and pyrrole ring structure.

2. Physical properties:(R)-1-Boc-2-cyanopyrrolidine is colorless to white crystal or powder, soluble in most organic solvents, such as ether, methanol, etc.

3. Use: it is an important intermediate in the synthesis of organic compounds, commonly used in the preparation of drugs, pesticides and bioactive molecules. Its cyano group can be further reacted for the construction of carbon-carbon and carbon-nitrogen bonds, C- C and C- N building reactions.

4. Preparation method: mainly obtained by reaction of cyano group and Boc protecting group on pyrrole ring. (R)-1-Boc-2-cyanopyrrolidine can be obtained by reacting lithium cyanate with sodium cyanate at (-40°C) and then reacting with the Boc-OSuccinimid group.

Last Update：2024-04-09 02:00:42