tiopentalsodium
Pentothal Sodium
CAS: 71-73-8
Molecular Formula: C11H17N2NaO2S
tiopentalsodium - Names and Identifiers
| Name | Pentothal Sodium |
| Synonyms | farmotal trapanal trapanalsodium tiopentalsodium Intraval sodium Pentothal Sodium Nesdonal sodium Thiothal sodium Thiopental Sodium thiopentone sodium (+-)-Thiopental Sodium 5-Ethyl-5-(1-methyl-butyl)-barbituric acid 5-ethyl-5-(1-methylbutyl)-2-thio-barbituricacisodiumsalt 5-ethyl-5-(1-methylbutyl)-2-thiobarbituricacidmonosodium 6(1h,5h)-pyrimidinedione,5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-monos 6(1h,5h)-pyrimidinedione,5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-monosod |
| CAS | 71-73-8 |
| EINECS | 200-763-1 |
| InChI | InChI=1/C11H18N2O2S.Na/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15;/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16);/q;+1/p-1 |
tiopentalsodium - Physico-chemical Properties
| Molecular Formula | C11H17N2NaO2S |
| Molar Mass | 264.32 |
| Solubility | H2O: >10mg/mL |
| Color | Yellowish hygroscopic powder |
tiopentalsodium - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | CQ6475000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice (mg/kg): 149 i.p.; 78 i.v. (Christensen, Lee) |
tiopentalsodium - Thiopental sodium for injection
Authoritative Data Verified Data
This product is a sterile powder of thiopental sodium 100 parts mixed with anhydrous sodium carbonate 6 parts. Based on the average loading, the content of sodium pentothal (C11H17N2Na02S) shall be 93.0% to 107.0% of the label loading.
trait
This product is light yellow powder.
identification
- take about 0.5g of this product, Add 10ml of water to dissolve thiopental sodium, and add excess dilute hydrochloric acid to form white precipitate; Filter, wash the precipitate with water, and dry at 105°C, the melting point measured according to law (General rule 0612) is 157 to 161°C.
- take about 0.1g of this product, Add 10ml of pyridine solution (1-10) to dissolve thiopental sodium, add 1 ml of copper pyridine test solution, shake and place for 1 min to generate green precipitate.
- take about 0.2g of this product, add 5ml of sodium hydroxide solution and 2ml of lead acetate solution, and generate white precipitate; After heating, the precipitate turns black.
- take this product, after ignition, show the flame reaction of sodium salt (General rule 0301).
examination
- alkalinity: Take 0.5g of this product, Add 10ml of water to dissolve it, and measure it according to law (General rule 0631). The pH value should be 9.5~11.2.
- the clarity of the solution is l.Og, and the solution should be clarified after 10ml of water is dissolved.
- take 0.30g of sulfate, add 23ml of water to dissolve, add 7ml of dilute hydrochloric acid, stir, filter, take 10ml of filtrate, add water to make 45ml, and check according to law (General rule 0802), not more concentrated (0.10%) than the control solution made of standard potassium sulfate solution.
- appropriate amount of related substances should be taken, dissolved with water and diluted to prepare a solution containing 10 mg of thiopental sodium per 1 ml, which should be used as a test solution. Take 1 ml for precision measurement and put it in a 200ml measuring flask, as a control solution, it was diluted to the scale with water and shaken. According to the thin layer chromatography (General 0502) test, absorb 20 u1 of each of the above two solutions, respectively point on the same silica gel GF254 thin layer plate, A lower solution of 13.5mol/L ammonia solution-ethanol-chloroform (5:15:80) was used as a developing solvent, developed, dried, and immediately examined under a UV lamp (254mn). Test solution such as impurity spots (except the origin), compared with the control solution of the main spot, not deeper.
- weight loss on drying this product shall be dried under reduced pressure at 80°C for 4 hours, and the weight loss shall not exceed 2.0% (General rule 0831).
- bacterial endotoxin this product, according to the law inspection (General 1143), per 1 mg of thiopental sodium endotoxin should be less than 0.50EU.
- sterile take this product, respectively, plus sterile water made per lml solution containing lOmg, according to the law inspection (General 1101), should comply with the provisions.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take the contents under the difference of loading amount, mix them evenly, weigh an appropriate amount (equivalent to 0.25g of thiopental sodium) accurately, and put them in a 500ml measuring flask, add water to dissolve thiopental sodium and dilute to the scale, shake well, take an appropriate amount with precision, and quantitatively dilute with 0.4% sodium hydroxide solution to make a solution containing about 5ug per 1 ml, according to UV-visible spectrophotometry (General rule 0401), determine the absorbance at the wavelength of 304mn; Take another sulfur pentodate reference substance, the solution containing about 5ug per 1 ml was prepared by dissolving and quantitatively diluting with 0.4% sodium hydroxide solution and determined by the same method. Calculated from the average loading per arm-equivalent to 1.091mg of C11H17N2Na02S per 1mg of thiopental.
category
intravenous anesthetics.
specification
Press (1)0.5g (2) lg
storage
light shielding, sealed storage.
Last Update：2024-01-02 23:10:35
