tolonidine
tolonidine
CAS: 4201-22-3
Molecular Formula: C10H12ClN3
tolonidine - Names and Identifiers
| Name | tolonidine |
| Synonyms | ST-375 tolonidine N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine |
| CAS | 4201-22-3 |
tolonidine - Physico-chemical Properties
| Molecular Formula | C10H12ClN3 |
| Molar Mass | 209.68 |
| Melting Point | 148-150° |
| pKa | 9.41(at 25℃) |
| In vivo study | In the anesthetized dog, tolonidine administered i.v. decreases the amplitude of ventricular contractions, reduces aortic blood flow and increases peripheral vascular resistances. In the bivagotomized pithed rat, tolonidine induces a long-lasting increase in blood pressure with no secondary hypotension, thus suggesting peripheral sympathomimetic properties. |
tolonidine - References
| biological activity | Tolonidine is a derivative of imidazoline. Tolonidine is effective orally and has antihypertensive and antihypertensive effects. |
Last Update：2024-04-10 22:29:15
