trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Names and Identifiers

Name	Hexythiazox
Synonyms	na73 trevi NA-73 Nissorun acarflor acariflor dpxy5893-9 Hexythiazox Hexythiazox E.C. 5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxamidtra trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami 5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamide trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxamide (4S)-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamide (4R,5R)-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamide (4S,5S)-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamide (4RS,5RS)-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamide
CAS	78587-05-0
EINECS	616-638-3
InChI	InChI=1/C17H21ClN2O2S/c1-11-15(12-7-9-13(18)10-8-12)23-17(22)20(11)16(21)19-14-5-3-2-4-6-14/h7-11,14-15H,2-6H2,1H3,(H,19,21)/t11-,15+/m0/s1

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Physico-chemical Properties

Molecular Formula	C17H21ClN2O2S
Molar Mass	352.88
Density	1.1354 (rough estimate)
Melting Point	108-108.5°C
Boling Point	128°C (rough estimate)
Flash Point	100°C
Water Solubility	Insoluble in water
Appearance	White Crystal
Color	White to Almost white
BRN	9001643
pKa	12.77±0.20(Predicted)
Storage Condition	0-6°C
Sensitive	Sensitive to light
Refractive Index	1.6100 (estimate)
MDL	MFCD00137385
Physical and Chemical Properties	Melting Point: 108 - 108.5 1, performance The original drug is white crystal, insoluble in water, soluble in a variety of organic solvents; Chemical stability, good permeability to crop surface, but no internal absorption. The drug has a strong killing effect on the young mites and eggs of a variety of spider mites, but has a poor effect on adult mites, and has a poor effect on rust mites and tumor mites. The agent has low toxicity to human beings and livestock, and has little effect on natural enemies, bees and fish in common doses, and can be mixed with various pesticides such as sulfur mixture and Bordeaux mixture. 2. Preparation 5% emulsifiable concentrate and 5% wettable powder. 3. Method of use (1) prevention and treatment of Citrus Red Spider: In the initial peak period of occurrence of Red Spider, when there are 2~3 mites per leaf on average, spray evenly with 1500~2000 times of 5% emulsifiable concentrate or 5% wettable powder. (2) to prevent and control the spider mites of vegetables and flower crops, when the young mites begin to peak and there are 3~5 mites per leaf on average, spray evenly with 1500~2000 times of 5% emulsifiable concentrate or 5% wettable powder. 4. Precautions (1) the drug has poor effect on adult mites, and the drug effect is slow. Therefore, the control should be carried out in the period from the hatching of mite eggs to the onset of juvenile mites. (2) the drug has no internal absorption, which requires even and thoughtful spraying. (3) in order to delay the emergence of drug resistance, it should be used with other acaricides.
Use	Broad insecticidal spectrum, with high acaricidal activity against dermoides mites, whole claw mites, etc

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Risk and Safety

Hazard Symbols	N - Dangerous for the environment
Risk Codes	50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 3077
WGK Germany	2
RTECS	XJ5396000
HS Code	29341000
Toxicity	LD50 in male, female mice, male, female rats (mg/kg): all >5000 orally; all >5000 dermally (Nippon Soda Co.)

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Reference Information

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
insect growth regulator and acaricide	thioridone is a kind of thiadiazine insect growth regulator with high selectivity, it has strong Contact killing effect and stomach poison effect. It has good control effect on planthoptera planthopper, leaf hopper, whitefly and scale insect hydrocarbon pests, and has long-lasting larvicidal activity against some coleopteran pests and mites. Can effectively control the rice planthopper and leaf hopper, tea, potato leaf hopper, citrus, vegetables on the whitefly, citrus on the shield and vermicelli. According to domestic research in rice plants have a certain role in the role of internal transport. Its mechanism of action is to inhibit insect chitin synthesis and interfere with metabolism, resulting in nymphs can not molt, or molt deformity, or eclosion deformity and slow death, with high nymphs activity. The general recommended dose can not directly kill adults, but can reduce egg laying, reduce the hatching rate of eggs and shorten their life span. The general application of 3 to 7 days after the effect can be seen, no direct killing of adult insects, but can shorten their life span, reduce egg production, and the output is mostly sterile eggs, the larvae die quickly even after hatching. It has a good control effect on the planthoptera, the Leaf, the whitefly and the scale insect pests, and the efficacy period is more than 30 days. It is relatively safe to natural enemies, and there is no problem of cross-resistance between hirudone and other insecticides, and the comprehensive effect is good. The action of the drug is slow, and the pest hazard can be controlled 3 to 7 days after application. When the population density is high, it should be mixed with quick-acting agents. thiazolidinone is also a kind of thiazolidinone acaricide, which has good penetration to the epidermal layer of plants, but has no effect of internal conduction. On a variety of plant mites have a strong egg killing, killing if the characteristics of the young mite, the adult mite is ineffective, but the docking to touch the liquid of the female adult mite eggs have a role in inhibiting hatching. The drug belongs to the non-temperature coefficient type acaricide, no significant difference in the use of different temperatures, the residual effect of a long period. The drug has good control effect on spider mites and poor control effect on rust mites and mite. In the common concentration of crop safety, can be mixed with the Bordeaux mixture, sulfur mixture and other pesticides.
toxicity	Acute oral LD50>5000mg/kg in rats and mice, acute percutaneous LD50>5000mg/kg, rats with acute inhalation of LC50>2mg/L (4H). It has no irritation to rabbit skin and slight irritation to eyes. Rats fed 2 years Test No effect dose of 23.1mg/kg. Teratogenic, carcinogenic and mutagenic phenomena were not found in animal experiments. Carp LC503.7mg/L (48h), acute oral quail LD50>5000mg/kg, Bee LD50>0.2mg/only.
Use	thiazolidinone acaricide. This product has a broad spectrum, a variety of spider mites of the young if mites and eggs have a good effect, but the effect of adult mites is poor, after the treatment of female mites adult, the egg can not hatch. The main effect is contact killing, which has good permeability to plant tissues and no internal absorption. The speed of efficacy is slow, but the residual effect can be up to 1 months or more. Safe for crops, feeding mites and beneficial insects. Such as the prevention and control of Apple Red Spider, in the young if the mite peak period, an average of 3~4 mites per leaf, with 5% emulsifiable concentrate or 5% wettable powder 1500~2000 times liquid spray. Use was discontinued 7 days before harvest. The product is a new thiazolidinone acaricide. Broad insecticidal spectrum, high acaricidal activity against spider mites, whole claw mites, low concentration, good effect, and has good residual effect, and organic phosphorus, dicofol and other non-interactive resistance, it is safe for crops, and safe for the beneficial insects of the predatory mites, but has no internal absorption, and has poor effect on adults. The insecticidal spectrum is broad, and has high acaricidal activity against dermoides mite and whole claw mite
production method	with trans 5-(4-chlorophenyl) 4-methyl-2-oxothiazolidinone and cyclohexyl isocyanate are obtained by condensation as starting materials. 20g of trans 5-(4-chlorophenyl)-4-methyl-2-oxothiazolidinone and 11.9g of cyclohexyl isocyanate were added to benzene, and the reaction was stirred at room temperature, after post-treatment, 30.7g of thioridone was obtained. Preparation of trans 5-(4-chlorophenyl)-4-methyl-2-oxothiazolidinone: condensation dehydration of trans-2-amino-1-p-chlorophenylpropanol with an equimolar amount of sulfuric acid in an organic solvent to form a trans-sulfuric acid ester, and then under alkaline conditions, A thiocarbamate derivative is formed by reacting with carbon oxysulfide, and at the same time, the carbon on Aggression of the phenyl group of the intramolecular sulfur atom is formed to p-, 5-trans-thiazolidinone. Formulated as 10% emulsifiable concentrate, 10% or 50% wettable powder. preparation of erythro -2-amino -1-p-chlorophenyl propanol sulfate 20g of a mixture of erythro -2-amino -1-p-chlorophenyl propanol and 21.9g of 50% sulfuric acid were mixed with benzene azeotropic distillation, water was removed to obtain the corresponding sulfuric acid ester in 99% yield. Preparation of trans-5-(4-chlorophenyl)-4-methyl-2-oxothiazolidinone cyclization with carbon disulfide in ethanol medium and in the presence of acid binding agent, and then obtained by oxidation. Method of operation: 5g of potassium hydroxide into aqueous solution, at room temperature added to 10.6g of red 2-amino -1-p-chlorophenyl propanol sulfate and 6.1g of carbon disulfide in ethanol mixture, the thiocyclization intermediate was obtained by controlling the reaction temperature at 40 ° C. And the reaction time at 3H. Then, 2.44g of this intermediate was reacted with 2.7g of sodium methoxide in methanol solution at room temperature, and oxidized with 5.2g of 30% hydrogen peroxide at 40 °c, the intermediate of substituted trans-thiazolidinone was obtained. The total yield of the two-step reaction was 79.8%. Trans-5-(4-chlorophenyl)-4-methyl-2-chlorothiazolidinone may also be used as a starting material from the sulfuric acid ester of erythro -2-amino -1-p-chlorophenyl propanol, in the presence of acid binding agent, with an excess of oxygen carbon sulfide, a one-step synthesis, reaction yield of 71%. Preparation of cyclohexyl isocyanate with xylene as solvent, 1mol carbon dioxide is reacted with 2mol cyclohexylamine to generate substituted carbamic acid, and then react with silicon tetrachloride or trimethyl silicon chloride to generate corresponding Ester, and then obtain cyclohexyl isocyanate by pyrolysis, the yield of this method is higher. Cyclohexylamine hydrochloride and Phosgene may also be used as raw materials to obtain cyclohexylisocyanate by pyrolysis of cyclohexylcarbamoyl chloride in an inert solvent. Or cyclohexylamine and carbon monoxide as raw materials, catalytic pressurized reaction of cyclohexyl isocyanate, still need to be further explored. The synthesis of thiofidone was prepared by addition reaction of trans-5-(4-chlorophenyl)-4-methyl-2-oxothiazolidinone and cyclohexyl isocyanate. Method of operation: 20.9g of trans-thiazolidinone and 11.9g of cyclohexyl isocyanate were stirred and reacted in benzene solvent at room temperature, and thiazolidinone was obtained by post-treatment with a yield of 94.8%. It has also been reported that the catalyst used is a strongly basic 1, 8-diazobicycl-5, 4-undec-7-ene (DBU).
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 19:05:15

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami

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Product Name: Hexythiazox Request for quotation
CAS: 78587-05-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
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Wuhan Xingzhongcheng Chemical limited company

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Product Name: Hexythiazox Request for quotation
CAS: 78587-05-0
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217

Wechat: 18627766980

Shanghai Yuanye Bio-Technology Co., Ltd.

Multiple Specifications

Product Name: Hexythiazox Visit Supplier Webpage Request for quotation
CAS: 78587-05-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Zouping Mingxing Chemical Co., Ltd.

Product Name: Hexythiazox Request for quotation
CAS: 78587-05-0
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Email: xuli678323@126.com
Mobile: +86-13605431940
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trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami

Hexythiazox

CAS: 78587-05-0

Molecular Formula: C17H21ClN2O2S

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Names and Identifiers

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Physico-chemical Properties

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Risk and Safety

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Reference Information

Supplier List

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami Request for Quotation

Hexythiazox

CAS: 78587-05-0

Molecular Formula: C17H21ClN2O2S

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Names and Identifiers

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Physico-chemical Properties

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Risk and Safety

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami - Reference Information

Supplier List

trans-5-(4-chlorophenyl)-n-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxami