trans-ACUB
trans-ACUB
CAS: 885012-33-9
Molecular Formula: C24H32N2O4
trans-ACUB - Names and Identifiers
trans-ACUB - Physico-chemical Properties
| Molecular Formula | C24H32N2O4 |
| Molar Mass | 412.52 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Use | trans-AUCB (t-AUCB) is a potent, orally active and selective soluble epoxide hydrolase (sEH) inhibitor with IC50 of 1.3 nM,8 nM,8 nM,8 nM for human, mouse and rat sEH, respectively. trans-AUCB has anti-glioma activity. |
trans-ACUB - Reference
| Reference Show more | 1: Gui Y, Li D, Chen J, Wang Y, Hu J, Liao C, Deng L, Xiang Q, Yang T, Du X, Zhang S, Xu D. Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse model of myocardial infarction. Lipids Health Dis. 2018 May 29;17(1):129. doi: 10.1186/s12944-018-0780-y. PubMed PMID: 29843720; PubMed Central PMCID: PMC5975509. 2: Gui YJ, Yang T, Liu Q, Liao CX, Chen JY, Wang YT, Hu JH, Xu DY. Soluble epoxide hydrolase inhibitors, t-AUCB, regulated microRNA-1 and its target genes in myocardial infarction mice. Oncotarget. 2017 Sep 18;8(55):94635-94649. doi: 10.18632/oncotarget.21831. eCollection 2017 Nov 7. PubMed PMID: 29212255; PubMed Central PMCID: PMC5706901. 3: Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Ledent C, Tilley SL, Nayeem MA. Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor (t-AUCB): Role of adenosine A(2A) receptor and plasma oxylipins. Prostaglandins Other Lipid Mediat. 2017 Jul;131:83-95. doi: 10.1016/j.prostaglandins.2017.09.001. Epub 2017 Sep 7. PubMed PMID: 28890385; PubMed Central PMCID: PMC5635996. 4: Li J, Tang C, Li L, Li R, Fan Y. Quercetin blocks t-AUCB-induced autophagy by Hsp27 and Atg7 inhibition in glioblastoma cells in vitro. J Neurooncol. 2016 Aug;129(1):39-45. doi: 10.1007/s11060-016-2149-2. Epub 2016 May 12. PubMed PMID: 27174198. |
trans-ACUB - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.424 ml | 12.121 ml | 24.241 ml |
| 5 mM | 0.485 ml | 2.424 ml | 4.848 ml |
| 10 mM | 0.242 ml | 1.212 ml | 2.424 ml |
| 5 mM | 0.048 ml | 0.242 ml | 0.485 ml |
Last Update：2024-01-02 23:10:35
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CAS: 885012-33-9
Tel: 18301782025
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CAS: 885012-33-9
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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