tri(cyclohexyl)-1H-1,2,4-triazol-1-yltin
Azocyclotin
CAS: 41083-11-8
Molecular Formula: C20H35N3Sn
tri(cyclohexyl)-1H-1,2,4-triazol-1-yltin - Names and Identifiers
| Name | Azocyclotin |
| Synonyms | Clermait Azocyclotin Tricyclotin AZOCYCLOTIN STANDARD azocyclotin (bsi,iso,esa) tri(cyclohexyl)-1H-1,2,4-triazol-1-yltin AZOCYCLOTIN PESTANAL (1-(TRICYCLO- HEXYL 1-(Tricyclohexylstannyl)-1H-1,2,4-triazole 1-tricyclohexylstannanyl-1H-[1,2,4]triazole 1H-1,2,4-Triazole, 1-(tricyclohexylstannyl)- tricyclohexylstannanylium 1,2,4-triazol-1-ide 1-(tricyclohexylstannyl)-1H-1,2,4-triazole azocyclotin |
| CAS | 41083-11-8 |
| EINECS | 255-209-1 |
| InChI | InChI=1/3C6H11.C2H2N3.Sn/c3*1-2-4-6-5-3-1;1-3-2-5-4-1;/h3*1H,2-6H2;1-2H;/q;;;-1;+1/rC18H33Sn.C2H2N3/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;1-3-2-5-4-1/h16-18H,1-15H2;1-2H/q+1;-1 |
tri(cyclohexyl)-1H-1,2,4-triazol-1-yltin - Physico-chemical Properties
| Molecular Formula | C20H35N3Sn |
| Molar Mass | 436.22 |
| Melting Point | 210℃ |
| Boling Point | 487.4±28.0 °C(Predicted) |
| Water Solubility | 0.12 mg l-1 (20 °C) |
| Vapor Presure | 2×10-11 Pa (20 °C, est.) |
| Appearance | neat |
| BRN | 621636 |
| pKa | 5.36 (weak base) |
| Storage Condition | 0-6°C |
| Physical and Chemical Properties | Colorless crystals. |
| Use | Is a contact acaricide, can kill young mites, if mites, adult mites and summer eggs and other mites |
tri(cyclohexyl)-1H-1,2,4-triazol-1-yltin - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R26 - Very Toxic by inhalation R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S38 - In case of insufficient ventilation, wear suitable respiratory equipment. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 2786 |
| WGK Germany | 3 |
| RTECS | WH8637700 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
tri(cyclohexyl)-1H-1,2,4-triazol-1-yltin - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| acaricide | triazole tin, also known as bezoar, is a kind of organic tin broad-spectrum acaricide, pure product is colorless crystal or powder, the melting point is 218.8 ℃, the original powder is white powder, the content of active ingredient is not less than 90%, and the vapor pressure is less than 499.96 × 10-5pa at 20 ℃. The light and rain have good stability, unstable in acidic medium, can be hydrolyzed, lose the triazole group. Insoluble in water, in dichloromethane, isopropanol and other organic solvents solubility is less than 1 g/kg, soluble in hexane, soluble in acetone, ether, chloroform. Under suitable storage conditions, the original drug can be stored for more than two years. Triazole tin is a broad-spectrum acaricide with strong Contact killing effect, which can kill mites, adult mites and summer eggs, and is ineffective for winter eggs, and the residual effect period can reach more than 30 days, it has a good control effect on sensitive and resistant mites. The toxicological mechanism may be related to the inhibition of oxidative phosphorylation in nerve cells. It is suitable for the control of Apple, citrus, grape, vegetable and other crops of apple whole claw mite, Hawthorn spider mite, citrus whole claw mite, citrus Rust mite, two spot spider mite, cinnabar spider mite, truncated Spider mite and so on. Moderate toxicity, rats with acute oral LD50 was 76~180 mg/kg, acute percutaneous LD50 was 1000 mg/kg. High toxicity to fish, moderate toxicity to birds, extremely low toxicity to bees. |
| toxicity | triazole tin is a moderately toxic acaricide. Acute oral LD50: male rat 209mg/kg, female rat 33mg/kg, guinea pig 261mg/kg, mouse 870 ~ 980mg/kg. Rat acute percutaneous LD50>5g/kg. The LC50 for acute inhalation in rats (4 hours) was approximately 0.02mg (as AE)/L of air. Two years feeding Test No effect dose: rats 5 mg/kg feed, mice 15 mg/kg feed, dog 10 mg/kg feed. The ADI for a human is 0.007mg/kg body weight. The acute oral LD50 of male Japanese quail is 144 mg/kg, and that of female Japanese quail is 195 mg/kg. Fish poisoning LC50(96 hours): 0.004mg/L for rainbow trout, golden rotunda 0.0093mg/L. Non-toxic to bees; LD50>100 μg/Bee (500sc). Daphnia LC50(48 hours) is 0.04mg/L. According to China's pesticide toxicity grading standards, triazole tin is a medium toxic acaricide. The acute oral LD50 of the original drug rats was 76~180mg/kg, and the acute percutaneous LD50 was 1000mg/kg. The acute oral LD50 of mice was 417 ~ 980mg/ kg. There was no "three" effect in the experimental dose, the maximum dose of chronic toxicity to rats was 5 mg/kg, and no abnormality was found in the third generation reproductive test. The LD50 of triazole tin is 175 ~ 375mg/kg in oral administration to birds, which is a base of toxicity to bees. 25% triazole tin WP is a low toxicity acaricide. The acute oral LD50 of rats is 611 ~ 631mg/ kg, the acute percutaneous LD50>1000mg/kg, and the LD50 of rats inhaled for 4 hours is 17.4~29mg/m3. The LD50(96 hours) for carp is 0.05~0.1mg/L, and the LC50(96 hours) for rainbow trout is 0.005~0.01mg/L. |
| method of use | (1) citrus whole claw mite, spider mite and six spider mite. A large number of citrus spring shoots (Bud length of 5 ~ 10cm), the initial period of the occurrence of mites to control, with beilepa 25% wettable powder 1500~2000 times liquid spray, valid for about 30 days. (2) citrus Rust mite. In the summer and autumn rust mites occurred early with the concentration of spray control, the effect is good, and can also treat the thorn moth. (3) Hawthorn spider mite, Apple whole claw mite. Before and after the flowering of apple trees or in the early stage of the occurrence of spider mites, 25% to 1500 times of 2000 or 20% to 1000 times of 1500 suspension of triazole tin was sprayed evenly on the crown of the tree. (4) grape spider mites. At the beginning of the peak, with 25% wettable powder 1000~1500 times liquid (effective concentration of 167 ~ 250mg/kg) uniform spray. (5) eggplant red spider. In the early stage of occurrence, the patient was sprayed with 25% ~ 1000 times of beilepa 1500 wettable powder (both positive and negative leaves should be sprayed), and the effect was good. (6) harmful mites on vegetables such as bean and eggplant. Prevention and Control of cinnabar spider mites, truncated spider mites, two spotted spider mites, according to the occurrence of mites, with effective ingredients per mu 10~20g (equivalent to 25% triazole tin wettable powder 40~80g) on water spray. |
| note | (1) triazole tin can be used in combination with organophosphorus insecticides, fungicide such as zinc and g-pill, however, it cannot be mixed with alkaline pesticides such as Bordeaux mixture and sulfur mixture. (2) stop using 21 days before harvest. (3) the drug should avoid contamination of human skin and eyes. If there is poisoning, the patient should be immediately placed in the air circulation, warm environment, while taking a lot of medical activated carbon water, and sent to the hospital for treatment. (4) the daily intake (ADI value) of triazole tin to human body is 0.003mg/kg per day. The guidelines for the safe and rational use of pesticides in China stipulates that triazole tin is used most frequently in crops per season; Apple is used 3 times and citrus is used 2 times. Safety interval: Apple for 14 days, citrus for 30 days. The maximum residue limits (MRL value) were 2 mg/kg. (5) before using the suspension, must first shake the bottle, and then use. (6) triazole tin should not be mixed with alkaline pesticides such as Bordeaux mixture or stone sulfur mixture, but should not be mixed with barien. There should be a certain interval with the Bordeaux mixture. In summer, the mixture should be sprayed with triazole tin before 7~10 days later. Mixed with other pesticides should first be tested for efficacy. |
| Use | a broad-spectrum organotin acaricide. The main effect is contact killing, and the residual effect is long. It has good effect on young mites, adult mites and summer eggs such as spider mites and rust mites, and is used to control citrus, Apple, Hawthorn, cotton, harmful mites of vegetables and other crops. Such as the control of Citrus Red Spider, citrus rust mites, cotton red spider, eggplant, beans, melon and other vegetable leaf mites, with 25% wettable powder 1000~2000 times liquid spray. Apple, Hawthorn Red Spider, grape and fruit role of spider mites with 1000~1500 times liquid spray. With its pesticide mixture, can expand the scope of prevention and control. This product is a contact acaricide, which can kill juvenile mites, if mites, adult mites and summer eggs and other mites. It is a contact acaricide, which can kill mites, such as juvenile mites, adult mites and summer eggs |
| production method | tin tetrachloride is reacted with cyclohexane chloride, chlorinated, alkalized, and then reacted with 1,2, the reaction of 4-triazole yields triazole tin. Raw material consumption quota: chlorocyclohexane 1600kg/t, 1,2, 4-triazole 230kg/t, tin 400kg/t, chlorine 1600kg/t. in the preparation reactor of tricyclohexyltin hydroxide, a magnesium plate is added in advance, and a certain amount of a mixed solution of chlorocyclohexane and THF is added at a high temperature under the protection of nitrogen. After the start of the reaction, continue to add the rest of the mixed solution, and after the reaction is completed, react with the xylene solution of tin tetrachloride to generate tricyclohexyltin chloride, dissolve the magnesium chloride with dilute hydrochloric acid, separate the layers, and remove the xylene, reaction with NaOH to produce tricyclohexyl tin hydroxide, after separation and drying to obtain the product. Synthesis of triazole tin tricyclohexyl tin hydroxide and acetone were added to the reactor, heated to reflux, and triazole acetone solution was added dropwise. After completion of the dropping, the mixture was heated to reflux, cooled to 0 ° C., filtered and dried to obtain triazole tin. The solvent was recovered from the filtrate. The following methods can also be used for the synthesis of triazole tin. |
| category | pesticide |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 100 mg/kg; Oral-mouse LD50: 700 mg/kg |
| flammability hazard characteristics | thermal decomposition of toxic nitrogen oxides, tin-containing gases |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| fire extinguishing agent | Sand, dry powder, foam |
| Occupational Standard | TWA 0.1 mg (tin)/m3; Tel 0.2 mg (tin)/M3 |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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