tribasiccalciumcitrate
Calcium Citrate anhydrous
CAS: 813-94-5
Molecular Formula: C12H10Ca3O14
tribasiccalciumcitrate - Names and Identifiers
| Name | Calcium Citrate anhydrous |
| Synonyms | citrical acicontral Calsium citrate Calcium citrate CALCIUM(II) CITRATE tricalcium dicitrate tribasiccalciumcitrate Citric acid calcium salt Calcium citrate tribasic Calcium Citrate anhydrous citric acid sesquicalcium Tricalcium Citrate anhydrous supply good quality calcium citrate |
| CAS | 813-94-5 |
| EINECS | 212-391-7 |
| InChI | InChI=1/2C6H8O7.3Ca/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h2*13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;;3*+2/p-6 |
tribasiccalciumcitrate - Physico-chemical Properties
| Molecular Formula | C12H10Ca3O14 |
| Molar Mass | 498.43 |
| Solubility | 1M HCl |
| Appearance | White to beige powder |
| Storage Condition | Room Temprature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Physical and Chemical Properties | White powder, soluble in water, difficult to dissolve in ethanol, due to the presence of trace amount of calcium hydroxide, the aqueous solution was slightly turbid and gradually lost when heated to 100 ℃, 120 ℃ completely lost. |
| Use | Chelating agents, buffers, tissue coagulants, calcium fortifiers, emulsifying salts. |
tribasiccalciumcitrate - Risk and Safety
| WGK Germany | 1 |
tribasiccalciumcitrate - Nature
Open Data Verified Data
white crystalline powder, odorless. Insoluble in ethanol, insoluble in water. Slightly hygroscopic. The water of crystallization was gradually lost by heating to 100 °c.
Last Update：2024-01-02 23:10:35
tribasiccalciumcitrate - Preparation Method
Open Data Verified Data
The citric acid solution was neutralized with milk of lime, filtered, washed and dried to obtain a finished product. Eggshell can also be used as raw material, after washing, grinding, calcination made of lime milk, and then neutralized with citric acid solution, and then filtered, washed with water, dried to get the finished product.
Last Update：2022-01-01 10:09:43
tribasiccalciumcitrate - Standard
Authoritative Data Verified Data
This product is 2-hydroxy-1, 2, 3-propane tricarboxylic acid calcium tetrahydrate. Calculated as dry product, containing C12H10Ca3014 shall not be less than 98.0%.
Last Update：2024-01-02 23:10:35
tribasiccalciumcitrate - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless.
- This product is insoluble in water or ethanol; Soluble in dilute hydrochloric acid.
Last Update：2022-01-01 13:39:08
tribasiccalciumcitrate - Use
Open Data Verified Data
Food calcium fortifier, the absorption effect is better than that of inorganic calcium. Can be used for a variety of food fortification, including infant formula, fruit juice, dairy products, solid drinks, sports drinks, milk, soy milk, health products and cereal products. China's provisions can be used for the valley and its products, the use of 8~16g/kg; In milk drinks and drink 11 8~3.6g/kg.
Last Update：2022-01-01 10:09:43
tribasiccalciumcitrate - Differential diagnosis
Authoritative Data Verified Data
- take about 0.5g of this product, add 10ml of water and 2.5ml of 2mol/L nitric acid solution to dissolve, add 1ml of mercury sulfate test solution, heat to boiling, and add 1ml of potassium permanganate test solution to generate white precipitate.
- take about 0.5g of this product, put it in a porcelain crucible, flash it completely at the lowest possible temperature, let it cool, add 10ml of water and 1 ml of glacial acetic acid to dissolve the residue, filter it, A few drops of ammonium oxalate test solution were added to the filtrate to generate a white precipitate, which was dissolved in hydrochloric acid.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1168).
Last Update：2022-01-01 13:39:08
tribasiccalciumcitrate - Exam
Authoritative Data Verified Data
loss on drying
This product is dried at 150°C for 4 hours, and the weight loss is 10.0% ~ 13.3% (General 0831).
insolubles in acid
take this product 5.og, add 10ml hydrochloric acid and 50ml water, heat in a water bath for 30 minutes to dissolve, filter with No. 4 vertical melting glass crucible, and wash the residue with 10ml water, after drying at 105°C for 2 hours, the remaining residue should not exceed 10 mg (0.2%).
Heavy metals
take 1.og of this product, add 15ml of water and 2ml of hydrochloric acid, dissolve, add 1.5ml of concentrated ammonia solution, add 2ml of acetate buffer (pH 3.5) and appropriate amount of water to make 25ml, inspection according to law (General Principles 0821, Law 1), containing heavy metals shall not exceed 10 parts per million.
arsenic salt
take l.Og of this product, add water 23ml and hydrochloric acid 5ml to dissolve, check according to law (General rule 0822 first law), should comply with the provisions (0.0002%).
fluoride
take 2.0g of this product, put the 50ml distillation bottle connected with Condenser tube, add 5ml of perchloric acid, 15ml of water and several pieces of glass beads; The bottle stopper has 2 holes, insert the dropping funnel filled with water (connected to the capillary tube) and the thermometer respectively; Insert the mercury ball at the front end of the capillary tube and the thermometer below the liquid level and slowly heat to 135°C, after about 5ml of water is added, the distillate is collected, and then human water is dripped from the dropping funnel through a capillary tube to maintain the temperature at 135-140°C, and the distillation is continued until the distillate reaches 75ml, the condenser tube was rinsed with water, diluted to 80ml, and shaken, and 40ml was placed in the cuvette as a test solution; Another 40ml was placed in another cuvette as a control solution. Add 0.1 mL of sodium alizarin sulfonate indicator solution to each of the two tubes, add 0.05mol/L sodium hydroxide solution Dropwise to the test solution until the color of the control solution is the same (just red), then add 0.1 ml of 1 mol/L hydrochloric acid solution, 0.025% thorium nitrate solution was added dropwise to the test solution to light red color, and the consumed volume was recorded. In the control solution, 0.025% thorium nitrate solution of the same volume was added dropwise, shake well, then add fluoride control solution (containing 20ug F per lml) to make the color of the solution consistent with the test solution, consumption of fluoride control solution should not exceed 1.5 (<0.003%).
Last Update：2022-01-01 13:39:10
tribasiccalciumcitrate - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add dilute hydrochloric acid 2ml and water 10ml dissolved, diluted with water to 100ml, add sodium hydroxide test solution 15ml and calcium red indicator 0.1g, titrated to blue with disodium ethylenediaminetetraacetate (0.05mol/L). Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) is equivalent to 8.307mg of C12H10Ca3O14.
Last Update：2022-01-01 13:39:10
tribasiccalciumcitrate - Category
Authoritative Data Verified Data
calcium supplement.
Last Update：2022-01-01 13:39:10
tribasiccalciumcitrate - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 13:39:10
tribasiccalciumcitrate - Calcium citrate tablets
Authoritative Data Verified Data
This product contains calcium citrate (C12H10Ca3014 • 4H20) should be labeled the amount of 95.0% ~ 105.0%.
trait
This product is a white tablet or a film-coated tablet, and the film-coated tablet is White after removing the coating.
identification
- take an appropriate amount of the fine powder of this product (about 0.5g of calcium citrate), add 10ml of water and 2.5ml of 2mol/L nitric acid solution, shake to dissolve the calcium citrate, filter, take the filtrate and add 1ml of mercury sulfate test solution, heat to boiling, and add 1ml of potassium permanganate test solution to generate white precipitate.
- take an appropriate amount of fine powder of this product (about 0.5g equivalent to calcium citrate), place it in a porcelain crucible, flash it completely at the lowest possible temperature, and let it cool, A mixture of 10ml of residual submergence water and 1 ml of glacial acetic acid is dissolved, filtered, and several drops of ammonium oxalate test solution are added to the filtrate to generate a white precipitate, which is dissolved in hydrochloric acid.
examination
- dissolution dissolution of this product, according to the dissolution and release determination method (General rule 0931 The first method), hydrochloric acid solution (9-100) as the dissolution medium, the speed is rpm, operate in accordance with the law, after 30 minutes, take the appropriate amount of the solution, filter, take the filtrate 20ml, add 1 mol/L sodium hydroxide solution 15ml, shake, place for 10 minutes, add triethanolamine 1 drop, shake, add a small amount of calcium red indicator, with ethylenediamine tetraacetic acid disodium titration solution (0.Olmol/L) titration to the solution of pure blue. Each 1 ml of ethylenediamine tetraacetic acid disodium titration solution (0.01 mol/L) is equivalent to 1.902mg of C12H10Ca3014.4H2O, and the dissolution amount of each tablet is calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 10 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about 0.8g equivalent to calcium citrate), put it in a 100ml measuring flask, add 8ml dilute hydrochloric acid and water, shake to dissolve calcium citrate, dilute to the scale with water, shake well, filter, take 25ml of continued filtrate, Add 75ml of water, add 15ml of sodium hydroxide test solution and caldansin indicator O.lg, with ethylenediamine tetraacetic acid disodium titration solution (0.05mol/L) titration to blue. Each 1 ml of ethylene diamine tetraacetic acid disodium titration solution (0.05mol/L) corresponds to 9.508mg of C12H10Ca3O14 · 4h2o.
category
Same as calcium citrate.
specification
0.5g (equivalent to calcium O.lg)
storage
sealed storage.
Last Update：2022-01-01 13:39:11
tribasiccalciumcitrate - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| calcium supplement preparation | inorganic calcium: calcium carbonate, calcium oxide (active calcium), calcium chloride, calcium hydrogen phosphate as the main functional components. Organic calcium: Calcium gluconate, calcium lactate, calcium citrate, calcium acetate. Calcium amino acid is a new calcium source, which is also organic calcium in terms of its chemical molecular composition, such as: calcium L-threonate, acid chelated calcium. How much calcium can be absorbed by the body is the most concerned. The absorption rate test showed that different calcium preparations containing 250 mg of elemental calcium were taken at the same time with a standardized breakfast, and the absorption rates were: malic acid, calcium citrate salt 35%, calcium carbonate salt 27%, calcium phosphate salt 25%, the effect of calcium supplementation was not significant, but calcium carbonate was the most cost-effective. |
| side effects | calcium citrate is a calcium salt derived from citric acid, a nutritional supplement for the prevention and treatment of calcium deficiency, it can promote the health of teeth and bones, and help to lose weight. Because it is soluble in water, it is the most easily absorbed calcium by the human body. Although there are many benefits, but there are also some side effects. Common side effects include bloating, constipation, and hiccups. If symptoms such as constipation, Nausea, Vomit, dry mouth or decreased appetite occur after taking calcium citrate, it should be stopped immediately and contact the doctor in time. Serious side effects include Dyspnea, difficulty swallowing, bone or Myalgia, severe weight loss, frequent urination, thirst, irregular heart rate and weakness, etc. |
| interacting agents | Tetracycline antibiotics, oxytetracycline, doxycycline, vitamin D supplements, Antacids containing aluminum or calcium. |
| identification test | take a sample of TS-158 mg and dissolve it in 10ml of water and ML of dilute nitric acid test solution, add 1 ml of mercury sulfate solution (TS-142), heat to boiling, and add potassium permanganate solution (TS-193). A white precipitate should be formed. 500mg of the sample was completely burned at the lowest possible temperature. After cooling, the residue was dissolved in 10ml of water and 1 ml of glacial acetic acid. After filtration, 10ml of ammonium oxalate test solution (TS-24) was added to the filtrate. A large amount of white precipitate soluble in hydrochloric acid should be formed. The infrared spectrum shall be in accordance with figure 06002. |
| content analysis | accurately weigh about 350mg of sample pre-dried at 150 ℃ for 4H, dissolve in 10ml water and 2ml dilute hydrochloric acid test solution (TS-117), dilute to about ml with water. Under stirring (preferably with a magnetic stirrer), add 0.05mol/L disodium EDTA about 30ml from a 50ml burette, then add 15ml of sodium hydroxide solution (TS-224) and 300mg of hydroxynaphthol blue indicator, titration was continued to the blue end point. Per Ml,0.05mol/L disodium EDTA is equivalent to calcium citrate [Ca3(C6H5O7)2]8.300mg. |
| toxicity | ADI is not specified (FAO/WHO,2001). No toxicity was actually shown. See citric acid ". GRAS(FDA,§ 182.1195,§ 182.5195,§ 182.6195,§ 182.8195,2000). |
| Use limit | GB 14880-94: cereals and their products, beverages, 8-16 g/kg. GB 2760 a 2000: soft drinks 0.44~3.7g/kg. FAO/WHO(1984,g/kg): low times concentrated milk, sweet condensed milk, cream, etc., single use 2, combined with other stabilizers 3 (anhydrous); Milk powder, cream Powder 5 (in anhydrous terms); Melted cheese manufacturing 40; Jam and jelly to maintain a pH of 2.8~3.5; Tomato canned for 800mg/kg, whole package is 450mg/kg (Ca); Cold drinks, caseinate, according to GMP. When used as a fortifier, the theoretical calcium content of this product is 21.07%, which can be used for flour, cakes, Japanese fermented soybean paste, etc. Japan Limited: ≤ 1% (Ca; Excluding special nutritious food). |
| Use | calcium citrate as a dietary calcium fortifier has better absorption effect than inorganic calcium. China's provisions can be used for cereals and their products, the use of 8~16 g/kg in milk drinks and drinks for 1.8~3.6g/kg. used as chelating agent, buffer, tissue coagulant, calcium fortifier, emulsifying salt, etc. chelating agent, buffer, tissue coagulant, according to FAO/WHO(1984), uses and limits are: low times concentrated milk, sweetened condensed milk, cream and so on single use 2G/kg, and other stabilizer dosage 3g/kg (based on Anhydrous); Milk powder, cream powder 5g/kg; melt dry manufacturing 40g/kg; Jelly, canned tomato, cold drinks, cold protein salt, according to GMP as a fortifier, the theoretical calcium content of the product is 21.07%, can be used for flour, cakes, japanese fermented soybean paste, Japan limited to 1%. calcium citrate is a calcium salt derived from citric acid. It is a nutritional supplement for the prevention and treatment of calcium deficiency. |
| production method | The citric acid solution was neutralized with milk of lime and reacted to form a precipitate, which was filtered, washed and dried to obtain a finished product. Eggshell can also be used as raw material, after cleaning, crushing, water immersion washing, drying, and then drying at 110 1H, and then calcined at 1000 1H, add water to make milk of lime; then neutralized with 3.5~4.0mol/L citric acid solution (citric acid slightly excess), and then precipitated, filtered, washed with water to Ph = 6~7, the final product was dried at 110 °c for 1H. The citric acid aqueous solution is neutralized with lime or calcium carbonate, and the resulting precipitate is filtered, washed, and dried. Alternatively, calcium chloride is added to an aqueous solution of sodium citrate. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:12
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