trifluoroacetyladriamycin-14-valerate
Valrubicin
CAS: 56124-62-0
Molecular Formula: C34H36F3NO13
trifluoroacetyladriamycin-14-valerate - Names and Identifiers
trifluoroacetyladriamycin-14-valerate - Physico-chemical Properties
| Molecular Formula | C34H36F3NO13 |
| Molar Mass | 723.64 |
| Density | 1.3473 (estimate) |
| Melting Point | 116-117 °C |
| Boling Point | 135-136 C |
| Flash Point | 478.6°C |
| Water Solubility | insoluble |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 3.81E-32mmHg at 25°C |
| Appearance | Solid |
| Color | Red |
| pKa | 7.34±0.60(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.618 |
| In vitro study | Valrubicin (AD 32) is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC 50 s of 0.85 and 1.25 μM, respectively. Valrubicin inhibits the binding of [ 3 H]PDBu to PKC. Therefore, Valrubicin competes with the tumor promoter for the PKC binding site and prevents the latter from both interacting with the phospholipid and binding to PKC. Valrubicin shows cytotoxic activity against squamous cell carcinoma (SCC) cell line colony formation, with IC 50 s and IC 90 s of 8.24 ± 1.60 μM and 14.81 ± 2.82 μM for UMSCC5 cells, 15.90 ± 0.90 μM, 29.84 ± 0.84 μM for UMSCC5/CDDP‡ cells, and 10.50 ± 2.39 μM, 19.00 ± 3.91 μM for UMSCC10b cells, respectively. Moreover, Valrubicin in combination with radiation enhances the cytotoxicity. |
| In vivo study | Valrubicin (3, 6, or 9 mg) reduces tumor growth at week 3 by intratumoral jection in hamster. Valrubicin (6 mg) combined with minimally cytotoxic irradiation (150, 250, or 350 cGy) causes significant tumor shrinkage in hamster. Valrubicin (0.1 μg/μL) significantly reduces the number of infiltrating neutrophils in biopsies challenged with TPA at 24 h and attenuates chronic inflammation in mice. Valrubicin also decreases the expression levels of inflammatory cytokines in the acute model. |
trifluoroacetyladriamycin-14-valerate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| HS Code | 2941906000 |
| Toxicity | dnd-hmn:lym 3 mg/L CJBIAE 58,720,80 |
trifluoroacetyladriamycin-14-valerate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.382 ml | 6.91 ml | 13.819 ml |
| 5 mM | 0.276 ml | 1.382 ml | 2.764 ml |
| 10 mM | 0.138 ml | 0.691 ml | 1.382 ml |
| 5 mM | 0.028 ml | 0.138 ml | 0.276 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: Valrubicin Visit Supplier Webpage Request for quotationCAS: 56124-62-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Valrubicin Visit Supplier Webpage Request for quotationCAS: 56124-62-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Valrubicin Visit Supplier Webpage Request for quotationCAS: 56124-62-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Valrubicin Visit Supplier Webpage Request for quotationCAS: 56124-62-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History