videoconferencing
Dehydronuciferine
CAS: 7630-74-2
Molecular Formula: C19H19NO2
videoconferencing - Names and Identifiers
videoconferencing - Physico-chemical Properties
| Molecular Formula | C19H19NO2 |
| Molar Mass | 293.36 |
| Density | 1.193±0.06 g/cm3(Predicted) |
| Melting Point | 130-131°C |
| Boling Point | 493.0±45.0 °C(Predicted) |
| Solubility | Insuluble (9.4E-3g/L) (25 c). Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, e |
| Appearance | Powder |
| pKa | 4.04±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | From lotus leaf |
videoconferencing - Reference
| Reference Show more | 1. [IF=5.279] Xianbao Deng et al."Analysis of Isoquinoline Alkaloid Composition and Wound-Induced Variation in Nelumbo Using HPLC-MS/MS."J Agr Food Chem. 2016;64(5):1130–1136 |
videoconferencing - Reference Information
| Plant Source: | lotus leaf |
| Background | there are dozens of alkaloids in lotus leaves, and many alkaloid compounds have been isolated from lotus leaves, according to the different structure of the mother nucleus, the alkaloids of lotus leaf can be mainly divided into 3 categories: single benzyl isoquinoline, dehydroaporphine and oxidized aporphine. Because the lone electron pair on the nitrogen atom in the molecule can accept protons, although most of them are alkaline, most of them are weak and cannot be directly dissolved in water, but can be dissolved in chloroform, ethanol, methanol and other organic solvents. Alkaloids and acid after the formation of salts, it is soluble in water, so the nuciferine can be extracted with acidic aqueous solution. When extracting with water, hydrochloric acid may be added to lower the pH of the extract to facilitate dissolution of the alkaloids. |
| preparation | the preparation process of the total alkaloid extract from Lotus leaves generally includes the following steps: (1) extraction: the solvent used can be water or any alcohol, ketone and Ester solvent, or a mixed solvent composed of these solvents in a certain proportion, or by these solvents and acids, an acidic or alkaline solvent. The extraction method may be decoction, heating reflux, ultrasonic extraction, cold dip, percolation, microwave extraction, high pressure extraction, etc. The optimal extraction process is: Lotus Leaf medicinal herbs with 30 ~ 90% ethanol, reflux extraction 2~3 times, each time extraction 1~2 hours, the amount of solvent is 15~30 times (L/kg). (2) filtration: including centrifugation, Suction filtration, ultrafiltration, pressure filtration and other methods, using or not using any one of the following clarifiers or combinations thereof: alcohol precipitation agent, gelatin, kaolin, various resins, polyethylene glycol, polyethylene glycol, chitosan and natural clarifier finished products such as 101 fruit juice clarifier, ZTC 1 natural clarifier, etc. (3) concentration: including film evaporation, rotary evaporation and boiling concentration under normal pressure or reduced pressure. (4) drying: including vacuum drying, spray drying, freeze drying, etc. when prepared by solvent extraction, the extract is generally first suspended in water, and then low polar esters, alkanes or ethers (such as petroleum ether, diethyl ether, hexane, gasoline, ethyl acetate, etc.) extraction to remove fat-soluble impurities, and then with a suitable polar solvent, such as chloroform, ethyl acetate, acetone, n-butanol, etc., or a mixture of these solvents, the total alkaloid components therein were extracted to obtain a total alkaloid extract. The composition of the alkaloid active ingredient of the lotus leaf is prepared by extracting from the dried leaves of nelumboci feragaertn., and contains a composition of various alkaloid active ingredients. These alkaloids mainly include nuciferine, N-demethylnuciferine, 0-demethylnuciferine, Annona alkaloid, nelumbinis, N-demethylpapaverine, 2-hydroxy-1-methoxy-aporphine, mesopaline, N-methylisohengzhou aconitine, N-methylhengzhou aconitine, dehydronuciferine, dehydroligine and other derivatives with its parent nucleus. |
| biological activity | Dehydronuciferine, isolated from the leaves of Nelumbo nucifera Gaertn, is an acetylcholinesterase (AChE) inhibitor, its IC50 was 25 μg/mL. |
| Target | IC50: 25 μg/mL (AChE) |
| Use | for content determination/identification/pharmacological experiments. |
Last Update：2024-04-09 20:52:54
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