z-Dl-Ala
N-Carbobenzyloxy-DL-alanine
CAS: 4132-86-9
Molecular Formula: C11H13NO4
z-Dl-Ala - Names and Identifiers
| Name | N-Carbobenzyloxy-DL-alanine |
| Synonyms | z-Dl-Ala NSC 27684 Z-DL-Ala-OH N-Cbz-DL-Ala Cbz-DL-alanine Z-DL-ALANINE extrapure N-Carbobenzyloxy-DL-alanine N-Cbz-DL-alanineZ-DL-Ala-OH N-Benzoxycarbonyl-DL-alanine N-[(benzyloxy)carbonyl]alanine Alanine,N-[(phenylMethoxy)carbonyl]- (2R)-2-{[(benzyloxy)carbonyl]amino}propanoate |
| CAS | 4132-86-9 |
| EINECS | 223-953-6 |
| InChI | InChI=1/C11H13NO4/c1-8(10(13)14)12-11(15)16-7-9-5-3-2-4-6-9/h2-6,8H,7H2,1H3,(H,12,15)(H,13,14)/p-1/t8-/m1/s1 |
z-Dl-Ala - Physico-chemical Properties
| Molecular Formula | C11H13NO4 |
| Molar Mass | 223.23 |
| Density | 1.2446 (rough estimate) |
| Melting Point | 112-113°C(lit.) |
| Boling Point | 364.51°C (rough estimate) |
| Flash Point | 209.1°C |
| Solubility | almost transparency in Methanol |
| Vapor Presure | 7.05E-08mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| BRN | 6847292 |
| pKa | 4.00±0.10(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.4960 (estimate) |
| MDL | MFCD00063125 |
| Physical and Chemical Properties | Melting Point: 112 - 113 |
z-Dl-Ala - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29242990 |
z-Dl-Ala - Introduction
N-Carbobenzyloxy-DL-alanine is an organic compound, commonly abbreviated as Cbz-DL-Ala. The following is a description of its nature, use, formulation and safety information:
Nature:
N-Carbobenzyloxy-DL-alanine is a white crystalline solid with a molecular formula of C12H13NO4 and a relative molecular mass of 235.24. It has two chiral centers and therefore exhibits optical isomers. It can be dissolved in many organic solvents, such as alcohol and dimethylformamide. It is a compound that is stable and relatively difficult to decompose.
Use:
N-Carbobenzyloxy-DL-alanine is a commonly used protective amino acid derivative. It can be used in the synthesis of peptides and proteins in which its carboxyl and amine groups can be linked by condensation reactions between amino acids to form peptide chains. The N-benzyloxycarbonyl protecting group can be removed by appropriate conditions after completion of the reaction to restore the original amino acid structure.
Preparation Method:
The preparation of N-Carbobenzyloxy-DL-alanine is usually carried out using N-benzyloxycarbonyl-alanine and an appropriate amount of DCC (diisopropylcarbamate) in an appropriate solvent. The reaction dehydrates to form an amide structure, which is then purified by crystallization to give the desired product.
Safety Information:
N-Carbobenzyloxy-DL-alanine are generally safe when used under appropriate operating conditions. However, since it is a chemical, guidelines for safe laboratory practices still need to be followed. It can be irritating to the eyes and skin, so wear appropriate personal protective equipment such as gloves and goggles during operation. In addition, it should be stored in a dry, well-ventilated place, away from fire and flammable materials. For more detailed information on their safe handling and handling, refer to the relevant safety data sheet (SDS) of the chemical or consult a professional.
Nature:
N-Carbobenzyloxy-DL-alanine is a white crystalline solid with a molecular formula of C12H13NO4 and a relative molecular mass of 235.24. It has two chiral centers and therefore exhibits optical isomers. It can be dissolved in many organic solvents, such as alcohol and dimethylformamide. It is a compound that is stable and relatively difficult to decompose.
Use:
N-Carbobenzyloxy-DL-alanine is a commonly used protective amino acid derivative. It can be used in the synthesis of peptides and proteins in which its carboxyl and amine groups can be linked by condensation reactions between amino acids to form peptide chains. The N-benzyloxycarbonyl protecting group can be removed by appropriate conditions after completion of the reaction to restore the original amino acid structure.
Preparation Method:
The preparation of N-Carbobenzyloxy-DL-alanine is usually carried out using N-benzyloxycarbonyl-alanine and an appropriate amount of DCC (diisopropylcarbamate) in an appropriate solvent. The reaction dehydrates to form an amide structure, which is then purified by crystallization to give the desired product.
Safety Information:
N-Carbobenzyloxy-DL-alanine are generally safe when used under appropriate operating conditions. However, since it is a chemical, guidelines for safe laboratory practices still need to be followed. It can be irritating to the eyes and skin, so wear appropriate personal protective equipment such as gloves and goggles during operation. In addition, it should be stored in a dry, well-ventilated place, away from fire and flammable materials. For more detailed information on their safe handling and handling, refer to the relevant safety data sheet (SDS) of the chemical or consult a professional.
Last Update：2024-04-10 22:29:15
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