Α-ZEARALENOL
α-Zearalenol
CAS: 36455-72-8
Molecular Formula: C18H24O5
Α-ZEARALENOL - Names and Identifiers
Α-ZEARALENOL - Physico-chemical Properties
| Molecular Formula | C18H24O5 |
| Molar Mass | 320.38 |
| Density | 1.174±0.06 g/cm3(Predicted) |
| Melting Point | 158-161°C |
| Boling Point | 599.0±50.0 °C(Predicted) |
| Flash Point | 2℃ |
| pKa | 7.61±0.60(Predicted) |
| Storage Condition | -20°C |
Α-ZEARALENOL - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R68/20/21/22 - R36 - Irritating to the eyes R11 - Highly Flammable R62 - Possible risk of impaired fertility R48/20 - R63 - Possible risk of harm to the unborn child R46 - May cause heritable genetic damage R45 - May cause cancer |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S16 - Keep away from sources of ignition. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. |
| UN IDs | UN 1648 3 / PGII |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8 |
| HS Code | 29322090 |
Α-ZEARALENOL - Reference
| Reference Show more | 1. Chen Yuzhu, Tang Qiyong, Zhang Lihui, Gu Meiying, Chu Min, Zhu Jing, AI nijiang ersman, Sun Jian, Zhang Zhidong. Identification and degradation characteristics of zearalenone-degrading bacteria [J]. Microbiology, 2021,48(02):383-391. |
Α-ZEARALENOL - Reference Information
| biological activity | α-zearalenol is a mycotoxin with high affinity for the estrogen receptor (ER), α-zearalenol is a derivative of zearalenone (ZEN), which can cause reproductive disorders in animals due to its xenogeneic estrogenic effects. |
| Cell Line: | MFC-7 cells Breast cancer cell lines: MCF-7 and MDA-MB231 MCF7 cells, MDA-MB231 cells HepG2 cells |
| Concentration: | 6.25 µM-25 µM 0.001 μM, 0.1 μM and 10 μM 0.001 μM, 0.1 μM and 10 μM 1 μM, 5 μM, 10 μM |
| Incubation Time: | 24 hours 24 hours, 48 hours, 72 hours 72 hours 72 hours |
| Result: | Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells. Modified the cell growth in two breast cancer cell lines. Observed an increase of cells in cell cycle in MCF7 cells. Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses. |
Last Update：2024-04-10 22:29:15
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