Α-溴乙酸甲酯
Methyl bromoacetate
CAS: 96-32-2
Molecular Formula: C3H5BrO2
Α-溴乙酸甲酯 - Names and Identifiers
| Name | Methyl bromoacetate |
| Synonyms | BAM BROMO METHYLACETATE Methyl bromoacetate Methyl α-Bromoacetate METHYL 2-BROMOACETATE BroMine Methyl acetate Bromoacetic acid methyl ester BROMOACETIC ACID METHYL ESTER Methyl BroMoacetate(Methyl 2-BroMoacetate |
| CAS | 96-32-2 |
| EINECS | 202-499-2 |
| InChI | InChI=1/C3H5BrO2/c1-6-3(5)2-4/h2H2,1H3 |
Α-溴乙酸甲酯 - Physico-chemical Properties
| Molecular Formula | C3H5BrO2 |
| Molar Mass | 152.97 |
| Density | 1.616 g/mL at 25 °C (lit.) |
| Melting Point | -50°C |
| Boling Point | 51-52 °C/15 mmHg (lit.) |
| Flash Point | 145°F |
| Water Solubility | Miscible with methanol, ether and acetone. Slightly miscible with water |
| Vapor Presure | 18 hPa (50 °C) |
| Appearance | Liquid |
| Specific Gravity | 1.416 |
| Color | Clear colorless to slightly yellow |
| BRN | 506256 |
| Storage Condition | Store below +30°C. |
| Refractive Index | n20/D 1.458(lit.) |
| Physical and Chemical Properties | Character: colorless transparent liquid. boiling point 144 ℃ (decomposition) freezing point <-50 ℃ relative density 1.655 refractive index 1.4586 flash point 62 ℃ soluble in ethanol, ether, acetone, benzene, insoluble in water. |
| Use | Used as intermediates and solvents in organic synthesis |
Α-溴乙酸甲酯 - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R34 - Causes burns R37 - Irritating to the respiratory system R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect R36/37/38 - Irritating to eyes, respiratory system and skin. R38 - Irritating to the skin |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - S36 - Wear suitable protective clothing. S16 - Keep away from sources of ignition. |
| UN IDs | UN 2643 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | AF6300000 |
| FLUKA BRAND F CODES | 19 |
| TSCA | Yes |
| HS Code | 29159080 |
| Hazard Class | 6.1 |
| Packing Group | II |
Α-溴乙酸甲酯 - Nature
Open Data Verified Data
colorless transparent liquid. Freezing point <50 °c. Boiling point of 144 deg C (decomposition),64(4. 399kPa). The relative density was 1.655. Refractive index 4586. Flash point 62 °c. Soluble in ethanol, ether, acetone, benzene, insoluble in water.
Last Update：2024-01-02 23:10:35
Α-溴乙酸甲酯 - Preparation Method
Open Data Verified Data
with glacial acetic acid as raw material, in acetic anhydride and red phosphorus, zeolite co-heat reflux, heating to 60~70 ℃, Dropwise adding bromine, heat preservation reaction after 1 hour, cooling, filtering, bromoacetic acid was distilled under reduced pressure to obtain bromoacetic acid, and then put into carbon tetrachloride with methanol, sulfuric acid was added, heated to reflux, and esterification was carried out. After methanol was recovered, the residue was washed, dried, and then distilled under reduced pressure.
Last Update：2022-01-01 10:33:24
Α-溴乙酸甲酯 - Use
Open Data Verified Data
organic synthesis intermediates, pesticides, mold removal agent solvents.
Last Update：2022-01-01 10:33:24
Α-溴乙酸甲酯 - Safety
Open Data Verified Data
is a highly toxic compound. Strong irritation of ocular mucosa. The stimulating concentration was 0.003mg/L. The concentration that can withstand 1 minute is 0.055 mg/L. It can also cause skin irritation and pulmonary edema. The operator should protect the respiratory organs and eyes with extreme care. The use of A- type filter Industrial anti-virus mask, wearing sealed glasses, gloves, wear work clothes. Production equipment should be strictly prevented from air leakage. Maximum allowable concentration of lOOmg/m3 in air.
Storage in brown glass bottles, external use of wooden box protection. Store in a cool, dry, ventilated place. Sunscreen, moisture, away from fire, heat source. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:33:25
Α-溴乙酸甲酯 - Reference Information
| freezing point | <-50 ℃ |
| LogP | 0.71 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | It is used as a solvent for organic synthesis intermediates, pesticides, and mold scavengers. used in organic synthesis used as intermediates and solvents in organic synthesis used in the synthesis of herbicides, and also used as intermediates in the manufacture of dyes and pharmaceuticals. |
| production method | is obtained by bromination of acetic acid followed by esterification with methanol. Glacial acetic acid, acetic anhydride, red phosphorus and several pieces of zeolite were added to the drying reactor, and heated to reflux. When the temperature rose to 60-70 °c, bromine was slowly added dropwise, and the heat preservation was about 1h after the addition. The mixture was filtered with cooling and then distilled under reduced pressure to obtain bromoacetic acid. Add bromoacetic acid and methanol to carbon tetrachloride, then add sulfuric acid, heat reflux dehydration, dehydration is completed, the carbon tetrachloride is distilled out, then add methanol reflux 1H, recover methanol, the residue is washed, after drying, vacuum distillation was performed to obtain a finished product. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | intravenous-mouse LDL0: 15.8 mg/kg |
| flammability hazard characteristics | open flame flammable; High heat releases toxic bromide gas |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature, separate storage of food additives |
| fire extinguishing agent | foam, water mist, sand, dry powder |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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View History
Α-溴乙酸甲酯
酸性铬蓝黑A
Benzoic acid, 2-methoxy-5-[(2-phenylhydrazinylidene)methyl]-, methyl ester
TRIS(3-TRIFLUOROACETYL-D-CAMPHORATO)EUROPIUM(III)
邻氟苯甲酸甲酯
1-NAPHTHALENESULFONIC ACID SODIUM SALT
6α,7α-Epoxy-5β-hydroxy-12-deoxyphorbol 13-decanoate
5-氯-6-乙基-3-羟基吡嗪-2-甲酰胺
2-(4-羟苯基)苯并[B]噻吩-6-醇
methyl 15-bromopentadecanoate
酸性铬蓝黑A
Benzoic acid, 2-methoxy-5-[(2-phenylhydrazinylidene)methyl]-, methyl ester
TRIS(3-TRIFLUOROACETYL-D-CAMPHORATO)EUROPIUM(III)
邻氟苯甲酸甲酯
1-NAPHTHALENESULFONIC ACID SODIUM SALT
6α,7α-Epoxy-5β-hydroxy-12-deoxyphorbol 13-decanoate
5-氯-6-乙基-3-羟基吡嗪-2-甲酰胺
2-(4-羟苯基)苯并[B]噻吩-6-醇
methyl 15-bromopentadecanoate