二異丙乙胺
N,N-Diisopropylethylamine
CAS: 7087-68-5
Molecular Formula: C8H19N
二異丙乙胺 - Names and Identifiers
| Name | N,N-Diisopropylethylamine |
| Synonyms | EDIA DIEA DIPEA Huenigs base Ethyldiisopropylamine ethyldiiso propylamine 3-METHYL-1-BUTINE-3-OL N-Ethyldiisopropylamine Diisopropyl triethylamine N,N-Diisopropylethylamine N-ethyl-N-isopropylpropan-2-amine N-ethyl-N-(propan-2-yl)propan-2-amine N-ETHYLDIISOPROPYLAMINE SOLUTION, ~2 M N-ETHYLDIISOPROPYLAMINE, 4X25 ML VIALS N,N-DIISOPROPYLETHYLAMINE (ATOFINA EDIPA |
| CAS | 7087-68-5 |
| EINECS | 230-392-0 |
| InChI | InChI=1/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3 |
| InChIKey | JGFZNNIVVJXRND-UHFFFAOYSA-N |
二異丙乙胺 - Physico-chemical Properties
| Molecular Formula | C8H19N |
| Molar Mass | 129.24 |
| Density | 0.742 g/mL at 25 °C (lit.) |
| Melting Point | <-50 °C (lit.) |
| Boling Point | 127 °C (lit.) |
| Flash Point | 6 °C |
| Water Solubility | miscible |
| Solubility | miscible |
| Vapor Presure | 31 mmHg ( 37.7 °C) |
| Appearance | Liquid |
| Specific Gravity | 0.755 (20/4℃) |
| Color | APHA: <20 |
| BRN | 605301 |
| pKa | 10.98±0.28(Predicted) |
| PH | 12.3 (H2O, 20℃)(as an emulsion) |
| Storage Condition | Store below +30°C. |
| Explosive Limit | 0.7-6.3%(V) |
| Refractive Index | n20/D 1.457 |
| Physical and Chemical Properties | The boiling point of 127 deg C, flash point 10 deg C, the relative density of 0.742. |
| Use | Used as a solvent for the synthesis of amino acid peptides |
二異丙乙胺 - Risk and Safety
| Risk Codes | R11 - Highly Flammable R22 - Harmful if swallowed R34 - Causes burns R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R10 - Flammable R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R20/22 - Harmful by inhalation and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R61 - May cause harm to the unborn child |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S16 - Keep away from sources of ignition. S27 - Take off immediately all contaminated clothing. S60 - This material and its container must be disposed of as hazardous waste. S23 - Do not breathe vapour. S9 - Keep container in a well-ventilated place. S53 - Avoid exposure - obtain special instructions before use. |
| UN IDs | UN 2734 8/PG 2 |
| WGK Germany | 2 |
| FLUKA BRAND F CODES | 9-34 |
| TSCA | Yes |
| HS Code | 29211980 |
| Hazard Note | Highly Flammable/Corrosive/Harmful |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: > 200 - 500 mg/kg |
二異丙乙胺 - Reference Information
| LogP | -1.8 at 22.5℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | diisopropylethylamine (DIPEA) is a colorless transparent liquid, insoluble in water, soluble in organic solvents such as acetone. DIPEA is an important pesticide and pharmaceutical intermediate, which can be used to synthesize anesthetics and herbicides, and can also be used as hindered amines to participate in various catalytic reactions. |
| Use | N,N-diisopropylethylamine (DIPEA) is a colorless transparent liquid, insoluble in water, soluble in organic solvents such as acetone. DIPEA is an important pesticide and pharmaceutical intermediate, which can be used to synthesize anesthetics and herbicides, and can also be used as hindered amines to participate in various catalytic reactions. biochemical research important organic synthesis intermediates, mainly used in medicine, pesticide intermediate synthesis, can also be used as solvent, condensation agent, Catalyst, for amino acid peptide synthesis, etc. |
| preparation | a synthesis method of DIPEA, followed by the following steps: 101.1g(1.0mol) diisopropylamine, 332.0g(2.0mol) tetraethylammonium chloride, 1.5g ethanol, 60g (mol) sodium hydroxide were charged to a ML three-necked flask, heated to reflux, and the reflux temperature was maintained (80 °c). The reaction was completed after 7 hours, cooled to room temperature, and the reaction mixture was freed from the solvent on a rotary evaporator, then washed with 200mL * 3 deionized water, and the three washed oil phases were combined and collected for direct atmospheric distillation, 124.1g of the 125-127 ° C. Fraction was collected, which was the product DIPEA with a yield of 96.2% and a purity of 99.5% as determined by gas chromatography. |
| autoignition temperature | 240°C |
Last Update：2024-04-10 22:29:15
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