双羟甲基乙炔
2-Butyne-1,4-diol
CAS: 110-65-6
Molecular Formula: C4H6O2
双羟甲基乙炔 - Names and Identifiers
双羟甲基乙炔 - Physico-chemical Properties
| Molecular Formula | C4H6O2 |
| Molar Mass | 86.09 |
| Density | 1.2 |
| Melting Point | 54 °C |
| Boling Point | 238°C(lit.) |
| Flash Point | 306°F |
| Water Solubility | 3740 g/L (20 ºC) |
| Solubility | 3740g/l |
| Vapor Presure | <0.1 mm Hg ( 55 °C) |
| Appearance | Crystalline Platelets or Flakes |
| Color | slightly brown |
| Exposure Limit | ACGIH: TWA 0.1 ppm; STEL 0.3 ppmOSHA: TWA 0.75 ppm; STEL 2 ppmNIOSH: IDLH 20 ppm; TWA 0.016 ppm; Ceiling 0.1 ppm |
| BRN | 1071237 |
| pKa | 12.72±0.10(Predicted) |
| PH | 4-7.5 (100g/l, H2O, 23℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Highly flammable solid. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong acids, strong bases. |
| Refractive Index | 1.4804 |
| Physical and Chemical Properties | White orthorhombic crystal (light yellow after moisture absorption) Melting Point: 58 ℃ Boiling Point: 238 ℃,145 ℃(2kPa) flash point 152 ℃ refractive index 1.450 solubility soluble in water, acid solution, ethanol and acetone, slightly soluble in chloroform, insoluble in benzene and ether Other properties of solid butynediol in 25 ° c air deliquescence, toxic, with the chemical properties of the two primary alcohol, but also can be added reaction. |
| Use | Used in organic raw materials, solvents, cyanide-free electroplating solution, also used in artificial leather, medicine and pesticide industry |
双羟甲基乙炔 - Risk and Safety
| Risk Codes | R21 - Harmful in contact with skin R23/25 - Toxic by inhalation and if swallowed. R34 - Causes burns R43 - May cause sensitization by skin contact R48/22 - Harmful danger of serious damage to health by prolonged exposure if swallowed. |
| Safety Description | S25 - Avoid contact with eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S46 - If swallowed, seek medical advice immediately and show this container or label. |
| UN IDs | UN 2716 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | ES0525000 |
| FLUKA BRAND F CODES | 23-10 |
| TSCA | Yes |
| HS Code | 29053980 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 100 mg/kg |
双羟甲基乙炔 - Upstream Downstream Industry
| Raw Materials | Calcium carbide Formaldehyde acetylene |
双羟甲基乙炔 - Nature
Open Data Verified Data
white orthorhombic crystals. Toxic. Soluble in water, acidic solution, ethanol and acetone, insoluble in ether and benzene. Melting Point: 58 °c. Boiling point 238 °c. Flash point 152 °c. Refractive index 450.
Last Update：2024-01-02 23:10:35
双羟甲基乙炔 - Preparation Method
Open Data Verified Data
using acetylene formaldehyde synthesis method. Acetylene containing 80% ~ 90% is compressed to a pressure of 0.4 ~ 0.5MPa, preheated to 70~80 ℃, and sent to the reactor, with copper butylene as catalyst, and formaldehyde in 110~112 deg C reaction, the crude product. The reaction product is concentrated and refined to obtain the finished product, and at the same time, propargyl alcohol is produced.
Last Update：2022-01-01 10:15:22
双羟甲基乙炔 - Use
Open Data Verified Data
can produce a series of raw materials such as butylene glycol, butylene glycol, Tetrahydrofuran, 7L butyrolactone, pyrrolidone, and further can produce synthetic plastics, synthetic fibers (nylon -4), solvent (N-methylpyrrolidone) and preservative. It is a good solvent, which is used as a brightener in the electroplating industry, and can also be used in the pharmaceutical and pesticide industries.
Last Update：2022-01-01 10:15:23
双羟甲基乙炔 - Safety
Open Data Verified Data
- on the upper respiratory tract, eye mucosa, skin has anesthetic stimulation. Long-term inhalation of vapor with a concentration of 0. 008~0. Olmg/L will cause pathological changes in the central nervous system, liver function and internal tissues. Rabbit and guinea pig oral LD50 0.125/kg production workshop air maximum allowable concentration
- reagent grade products are packaged in brown glass bottles of 500g each. Also available in plastic bottle packaging, lkg per bottle. Industrial products are packaged in plastic bottles of lkg, or in plastic barrels of 20kg or in iron barrels of lOOkg. Should be stored in a cool, ventilated, dry place. Protection against heat, sun and moisture. According to the provisions of toxic substances storage and transportation.
Last Update：2022-01-01 10:15:23
双羟甲基乙炔 - Reference Information
| LogP | -0.73 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Application | butynediol can be made from butene diol, butanediol, n-butanol, dihydrofuran, Tetrahydrofuran, γ-butyrolactone, A series of important organic products such as pyrrolidone can be further manufactured into synthetic plastics, synthetic fibers (nylon -4), artificial leather, pharmaceuticals, pesticides, solvents (N-methylpyrrolidone) and preservatives. Butynediol itself is a good solvent and is used as a brightener in the electroplating industry. used in the production of butylene glycol, butylene glycol, Γ-butyrolactone and other series of chemical products used as organic synthesis intermediates and instrument electroplating materials primary nickel brightener used in organic raw materials, solvents, cyanide-free electroplating solution, also used in leather, pharmaceutical and pesticide industry butadiene synthesis intermediates, corrosion inhibitors, electroplating brightener, polymerization catalyst, defoliant, chlorinated hydrocarbon stabilizer. |
| production method | 1. Using acetylene formaldehyde synthesis method containing 80%-90% of acetylene by compression to 0.4-0.5MPa pressure, preheating to 70-80 ℃, sent to the reactor, with buynone as catalyst, and formaldehyde in 110-112 ° C reaction, the crude product. The reaction product is concentrated and refined to obtain the finished product, and at the same time, propargyl alcohol is produced. 2. Paraformaldehyde atmospheric pressure solvent method: with paraformaldehyde as raw material, with cycloethanone as solvent, in the presence of copper catalyst acetylene, acetylene is introduced into the reactor, and the temperature is kept at 115-120 ℃, after the formaldehyde is completely converted, the acetylene is stopped, the catalyst is filtered out, and the reaction solution is concentrated and recrystallized to obtain crystalline butynediol. |
| category | flammable solid |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 104 mg/kg; Oral-mouse LD50: 105 mg/kg |
| explosive hazard characteristics | explosive when mixed with oxidant; Explosive when exposed to heat; And trace alkali or alkaline earth metal hydroxides, strong acid, chloride salt, Mercury salt; Medium explosive |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| extinguishing agent | water, carbon dioxide, foam, 1211 extinguishing agent |
| Occupational Standard | sel 1 mg/m3 |
| spontaneous combustion temperature | 410°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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View History
双羟甲基乙炔
Cholesterol Heptadecanoate
聚肌苷酸(多聚肌苷酸)
HOLMIUM-166M GAMMA-RAY EMISSION RATE STANDARD
TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE
邻溴三氟甲苯(邻三氟甲基溴苯)
苄酰丙二酸二乙酯
Benzene, 1,1'-(1-methylethylidene)bis[3-[(2-methyl-2-propen-1-yl)oxy]-
BETA-D-半乳糖基-(1-3)-N-乙酰基-D-半乳糖胺
Praseodymium chloride (PrCl2) (7CI,8CI,9CI)
Cholesterol Heptadecanoate
聚肌苷酸(多聚肌苷酸)
HOLMIUM-166M GAMMA-RAY EMISSION RATE STANDARD
TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE
邻溴三氟甲苯(邻三氟甲基溴苯)
苄酰丙二酸二乙酯
Benzene, 1,1'-(1-methylethylidene)bis[3-[(2-methyl-2-propen-1-yl)oxy]-
BETA-D-半乳糖基-(1-3)-N-乙酰基-D-半乳糖胺
Praseodymium chloride (PrCl2) (7CI,8CI,9CI)
Raw Materials for 双羟甲基乙炔