反式-(4-羟基环己基)氨基甲酸叔丁酯

反式-(4-羟基环己基)氨基甲酸叔丁酯 - Names and Identifiers

Name	Boc-Trans-4-Aminocyclohexanol
Synonyms	Boc-Trans-4-Aminocyclohexanol BOC-TRANS-4-AMINOCYCLOHEXANOL TRANS-4-BOC-AMINOCYCLOHEXANOL Trans-4-Boc-Aminocyclohexanol TRANS-4-N-BOC-AMINOCYCLOHEXANOL Trans-4-N-Boc-Aminocyclohexanol TRANS-4-BOC-AMINO-1-CYCLOHEXANOL Trans-4-Boc-Amino-1-Cyclohexanol N-T-BOC-TRANS-4-AMINO CYCLOHEXANOL N-T-Boc-Trans-4-Amino Cyclohexanol tert-butyl (4-hydroxycyclohexyl)carbamate Trans-T-Butyl-4-Hydroxycyclohexylcarbamate TRANS-T-BUTYL-4-HYDROXYCYCLOHEXYLCARBAMATE Tert-Butyl Trans-4-Hydroxycyclohexylcarbamate TERT-BUTYL TRANS-4-HYDROXYCYCLOHEXYLCARBAMATE tert-butyl (cis-4-hydroxycyclohexyl)carbamate N-benzyl-1-methoxy-N-[(trimethylsilyl)methyl]methanamine Trans-(4-Hydroxy-Cyclohexyl)-Carbamic Acid Tert-Butyl Ester TRANS-(4-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
CAS	111300-06-2
InChI	InChI=1/C11H21NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h8-9,13H,4-7H2,1-3H3,(H,12,14)/t8-,9+
InChIKey	DQARDWKWPIRJEH-KYZUINATSA-N

反式-(4-羟基环己基)氨基甲酸叔丁酯 - Physico-chemical Properties

Molecular Formula	C11H21NO3
Molar Mass	215.29
Density	1.06±0.1 g/cm3(Predicted)
Melting Point	172-173°C
Boling Point	337.7±31.0 °C(Predicted)
Flash Point	158°C
Solubility	Chloroform. Ethyl Acetate
Vapor Presure	7.02E-06mmHg at 25°C
Appearance	Solid
pKa	12.36±0.40(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.485
MDL	MFCD03844613

反式-(4-羟基环己基)氨基甲酸叔丁酯 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note	Irritant

反式-(4-羟基环己基)氨基甲酸叔丁酯 - Introduction

Trans-4-BOC-aminocyclohexanol, full name trans-4-tert-butoxycarbonyl aminocyclohexanol, is an organic compound. Its chemical formula is C12H23NO3 and its molecular weight is 229.32g/mol.

Nature:
trans-4-BOC-aminocyclohexanol is a white crystalline solid with a faint ammonia odor. Its melting point is in the range of about 85-88 degrees Celsius. It is readily soluble in organic solvents such as dimethyl sulfoxide and methylene chloride, but insoluble in water.

Use:
trans-4-BOC-aminocyclohexanol is an intermediate of organic synthesis. It is widely used in the field of drug synthesis, especially for the synthesis of biologically active compounds. As a protecting group, it is also commonly used in the synthesis of other compounds, and plays a role in protecting other functional groups in the synthesis reaction.

Preparation Method:
The preparation of trans-4-BOC-aminocyclohexanol is usually carried out by reacting trans-cyclohex-4-ol and tert-butyl carboxylic anhydride under basic conditions. The reaction is usually carried out in a suitable solvent, such as dimethyl sulfoxide or methylene chloride, and the reaction temperature is generally carried out at room temperature.

Safety Information:
trans-4-BOC-aminocyclohexanol is less harmful to human body under normal conditions, but it is still necessary to pay attention to safe use. Direct contact with the skin, eyes and respiratory tract should be avoided. In case of contact, rinse immediately with water and seek medical advice. In addition, the compound should be stored and handled properly to avoid contact with oxidants and strong acids to prevent fire and explosion accidents.

Last Update：2024-04-09 20:52:54