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头孢噻肟酸

Cefotaxime

CAS: 63527-52-6;152186-43-1

Molecular Formula: C16H17N5O7S2

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头孢噻肟酸 - Names and Identifiers

Name Cefotaxime
Synonyms Cefabol
Cefotaxime
Cephotaxime
Cefotaxima acid
Cefotaxime acid
(6R)-3-(Acetoxymethyl)-7α-[[(2-amino-4-thiazolyl)[(Z)-methoxyimino]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-3-[(acetyloxy)methyl]-7-{[(2-amino-1,3-thiazol-4-yl)(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-3-[(Acetyl-oxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)-acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, (6R,7R)-
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, [6R-[6α,7α(Z)]]-
(6S,7S)-3-[(acetyloxy)methyl]-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-3-[(acetyloxy)methyl]-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-3-[(acetyloxy)methyl]-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
sodium (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
(((2-amino- 4-thiazolyl)methoxyimino)acetyl)amino)-8-oxo-, (6r-(6alpha,7beta(z) 3-[(Acetyloxy)methyl]-7-[[(2-amino-4-thiazoly)(methoxyimino)acethyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid(sodium salt)
CAS 63527-52-6
152186-43-1
EINECS 264-299-1
InChI InChI=1/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m0/s1

头孢噻肟酸 - Physico-chemical Properties

Molecular FormulaC16H17N5O7S2
Molar Mass455.47
Density1.80±0.1 g/cm3(Predicted)
Melting Point>158°C (dec.)
Solubility DMSO (Slightly), Methanol (Slightly)
AppearanceWhite powder
ColorWhite to Off-White
pKapKa 2.1 (H2O t=20.0 I<0.005 ) (Uncertain);3.4(H2O t=20.0 I<0.005 ) (Uncertain);10.9(H2O t=20.0 I<0.0
Storage ConditionHygroscopic, -20°C Freezer, Under inert atmosphere
StabilityHygroscopic
Refractive Index1.778
Physical and Chemical PropertiesWhite powder. Melting point 162-163 °c (decomposition). Soluble in water. The dilute solution is colorless or yellowish, and the concentration is gray yellow. It is dark yellow or brown in texture.
UseSemi-synthetic oxime-type cephalosporins are the third generation cephalosporins. This product has a strong effect on Gram-negative bacteria, especially on Enterobacteriaceae. Mainly used for respiratory infections caused by sensitive bacteria, urinary tract infections, biliary tract and intestinal infections, skin and soft tissue infections, Burns and bone and joint infections.
In vitro study Cefotaxime exhibits an MIC of 0.0625 mg/L for V. vulnificus CMCP6.

头孢噻肟酸 - Risk and Safety

RTECSXI0240000
HS Code29419000

头孢噻肟酸 - Reference

Reference
Show more
1. Zhao Suhua, fan Hongjie. Serotype identification and drug resistance analysis of avian Escherichia coli in northern Anhui [J]. Journal of Animal Husbandry and Veterinary Medicine, 2017, 49(004):95-98.
2. [IF = 7.963] Xiu-Xiu Kong et al."The biodegradation of cefuroxime, cefotaxime and cefpirome by the synthetic consortium with probiotic Bacillus clausii and investigation of their close biodegradation pathways." Sci Total Environ. 2019 Feb;651:271
头孢噻肟酸
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Cefotaxime Request for quotation
CAS: 63527-52-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Cefotaxime acid Visit Supplier Webpage Request for quotation
CAS: 63527-52-6
Tel: 18301782025
Email: 3008007409@qq.com
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QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Cefotaxime Request for quotation
CAS: 63527-52-6
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Cefotaxime acid Visit Supplier Webpage Request for quotation
CAS: 63527-52-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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头孢噻肟酸
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