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富马酸替诺福韦二匹夫酯

Tenofovir disoproxil fumarate

CAS: 202138-50-9

Molecular Formula: C23H34N5O14P

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富马酸替诺福韦二匹夫酯 - Names and Identifiers

Name Tenofovir disoproxil fumarate
Synonyms Aids031697
Aids-031697
Bis(neopentyloc)pmpa
Tenofovir disoproxil fumarate
Tenofovir diisoproxil fuMarate
Tenofovir dipivoxil FuMarate(TDF)
Tenofovir Disoproxil Fumarate (200 mg)
9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate
bis({[(1-methylethoxy)carbonyl]oxy}methyl) {[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonate (2E)-but-2-enedioate
2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-
2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate
CAS 202138-50-9
EINECS 687-766-5
InChI InChI=1/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1

富马酸替诺福韦二匹夫酯 - Physico-chemical Properties

Molecular FormulaC23H34N5O14P
Molar Mass635.52
Melting Point113-115°C
Boling Point642.7°C at 760 mmHg
Flash Point342.5°C
Solubility DMSO (Slightly), Methanol (Slightly)
Vapor Presure2.06E-16mmHg at 25°C
AppearanceWhite to pink crystals
Colorwhite to beige
Storage Condition2-8°C
In vitro studyThe circulation of Tenofovir is actively secreted by the kidneys through glomerular filtration and renal tubules. Tenofovir is not a substrate for human organic cation transport type 1 (hOCT1) or hoct2. In MRP4 overexpressing cells, Tenofovir accumulates to five-fold lower levels, and MRP inhibitors can increase its accumulation. Tenofovir does not significantly affect mitochondrial DNA(mtDNA) in human hepatoblastoma (HCC) cells, skeletal muscle cells (SkMCs) or renal proximal tubule epithelial cells. In HepG2 cells or SkMCs, Tenofovir increased lactate production by less than 20%. Tenofovir is a potent phosphorylation of Tenofovir diphosphate (TFV-DP) in HepG2 cells and human primary hepatocytes. In the cell-based assay, the 50% effective concentration of Tenofovir anti-HBV was 1.1 mM, with a 50-fold increase in efficiency after the addition of the pre-bis-isoproxil group. In Vitro and clinically, Tenofovir has full activity against lamivudine-resistant HBV. Tenofovir inhibited the proliferation of hepatogenic hepatocellular carcinoma cells and normal skeletal muscle cells with CC(50) values of 398 μm and 870 μm, respectively. Tenofovir has a weaker effect than cidofovir on the proliferation and viability of renal proximal tubular epithelial cells, and cidofovir has a potential related nucleotide analog to induce renal tubular dysfunction.

富马酸替诺福韦二匹夫酯 - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
HS Code2933599550

富马酸替诺福韦二匹夫酯 - Reference

Reference
Show more
1. Yan Pengfei, Cui Yixuan, Liu Di et al.. Determination of 9-propenyladenine in tenofovir disoproxil fumarate by dispersion liquid-liquid microextraction combined with HPLC [J]. Analysis Laboratory 2019 v.38(12):58-61.
2. [IF = 3.414] Qing Zhao et al."Effects of traditional Chinese medicine formula Le-Cao-Shi on hepatitis B: in vivo and in vitro studies." J Ethnopharmacol. 2019 Nov;244:112132
富马酸替诺福韦二匹夫酯
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Tenofovir disoproxil fumarate Request for quotation
CAS: 202138-50-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Tenofovir disoproxil fumarate Request for quotation
CAS: 202138-50-9
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
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MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: Tenofovir DF; Bis(POC)-PMPA fumarate; GS 4331 fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: Tenofovir disoproxil fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Tenofovir disoproxil fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: Tenofovir disoproxil fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Tenofovir Disoproxil Fumarate Visit Supplier Webpage Request for quotation
CAS: 202138-50-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
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