屠锈胺
Metolachlor
CAS: 51218-45-2
Molecular Formula: C15H22ClNO2
屠锈胺 - Names and Identifiers
屠锈胺 - Physico-chemical Properties
| Molecular Formula | C15H22ClNO2 |
| Molar Mass | 283.79 |
| Density | 1.1200 |
| Melting Point | 25°C |
| Boling Point | bp0.001 100° |
| Flash Point | 2°C |
| Water Solubility | 529.7mg/L(20 ºC) |
| Vapor Presure | 7.91E-07mmHg at 25°C |
| Appearance | neat |
| BRN | 8396147 |
| pKa | 1.45±0.50(Predicted) |
| Storage Condition | APPROX 4°C |
| Sensitive | Sensitive to light |
| Refractive Index | 1.526-1.529 |
| MDL | MFCD00055293 |
| Physical and Chemical Properties | The pure product is a colorless liquid, and the industrial product is a brown oily liquid. B. p.100 °c/0.133, vapor pressure 1.73 x 10-3Pa (20 °c), relative density 1.12 (20). Soluble in methanol, dichloroethane and other organic solvents, solubility in water for 530mg/L. Not easy to light decomposition, storage for two years stable, half-life of 25d. |
| Use | Suitable for corn, soybean, peanut, cotton, sorghum and other dry field crops |
屠锈胺 - Risk and Safety
| Risk Codes | R43 - May cause sensitization by skin contact R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. |
| UN IDs | UN1648 3/PG 2 |
| WGK Germany | 2 |
| RTECS | AN3430000 |
| HS Code | 29242990 |
| Toxicity | LD50 in rats (mg/kg): 2780 orally; >3170 dermally (Gerber) |
屠锈胺 - Upstream Downstream Industry
| Raw Materials | Benzene Chloroacetyl chloride Triethylamine |
屠锈胺 - Introduction
The solubility in water at 20 ℃ is 530ppm, which is soluble in most organic solvents.
Last Update：2022-10-16 17:25:43
屠锈胺 - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| toxicity | acute oral LD50 of rats is 2780mg/kg, acute percutaneous LD50>3170mg/kg, acute inhalation LC50>1750mg/m3 (4h). It has no irritation to rabbit eyes and mild irritation to skin. The 90-day feeding test had no effect of 1000mg/kg for rats and 500mg/kg for dogs. The 2-year feeding test dose was 1000mg/kg for rats and 3000mg/kg for mice. No teratogenic, carcinogenic and mutagenic effects were found in animal experiments. Toxic to fish, rainbow trout LC50 is 3.9mg/L, catfish LC50 is 4.9mg/L. Low toxicity to birds. It has stomach toxicity to bees, but no contact toxicity. |
| use | selective pre-seedling herbicide. Gramineae weeds inhibit protein synthesis to death after absorbing agents through young buds and roots. It is suitable for corn, soybeans, rape, cotton, sorghum, vegetables and other crops to prevent and remove annual gramineous weeds such as crabgrass, barnyard grass, oxen grass, Setaria, Thrivegrass, and other annual gramineous weeds. The effect is poor, such as the mixed growth of broad-leaved grass and gramineous weeds, the two chemicals can be mixed and used. To control weeds in soybean and corn fields, spray soil surface with 72% emulsifiable concentrate and 15~23mL/100m2 water from sowing to emergence. This product is a pre-bud herbicide, which is mainly used to control gramineous weeds. The product is a 2-chlorinated acetoaniline herbicide, which is a cell division inhibitor. It can be used for soil treatment to control paddy field barnyard grass, heterotypic sedge, beef felt, duck tongue grass, and narrow leaf Alisma. It is usually used 3~5 days before transplanting. The product has poor selectivity to wet-inserted rice when applied alone, and has excellent selectivity to direct-inserted rice when used together with the solution. If the mixture of the product and the solution of the grass is used in 600 + 200gai/ha, the effect on duck tongue grass, special sedge, valve flower, fluttering grass and other effects are above 90%, while the control effect for thousand gold is up to 100%. Suitable for dry crops such as corn, soybean, peanut, cotton, sorghum, etc. |
| Production method | First, 2-methyl-6-ethylaniline reacts with 2-chloropropanol to generate N-(1-methyl-2-Hydroxyethyl)-2-methyl-6-ethylaniline, it then reacts with chloroacetyl chloride to produce N-(1-methyl-2-hydroxyethyl) chloroacetyl 2-methyl-6-ethylaniline. The latter reacts with methanol to produce alachlor. Another production method is to stir and react 2-ethyl-6-methylaniline and 2-bromo-1-methoxypropane at 120°C and 1.33kPa for 40h to obtain 2-ethyl-6-Methyl-N-(1 '-methoxy-propyl-2-yl) aniline, and then drop the benzene solution of the above intermediate in the presence of triethylamine to chloroacetyl chlorobenzene, stirred reaction at room temperature for 2h, washed, dried and distilled to obtain prochlorachlor product. Raw material consumption quota: 2,6-diethylaniline 540kg/t, 2-bromo -1-methoxypropane 310kg/t, triethylamine 510kg/t, benzene 40kg/t. Preparation method 1 uses 2-ethyl-6-methylaniline as raw material. The two hydrogen atoms on the amino group are first condensed with 2-chloropropanol, losing a molecule of hydrogen chloride, and then condensed with chloroacetyl chloride, Lose a molecule of hydrogen chloride. Finally, it reacts with methanol to etherify to form metolachlor. The yield of the second step of this method may be low. Preparation method Di2-ethyl-6-methylaniline and 2-bromo-1-methoxypropane are stirred and reacted at 120 ℃, 1.33 × 103Pa for 40h to obtain 2-ethyl-6-methyl-N-(1 '-methoxy-propyl-2-yl) aniline, and then in the presence of triethylamine, the benzene solution of the above intermediate is added dropwise to the chloroacetyl chlorobenzene solution, and the reaction is stirred at room temperature for 2h, after washing, drying and distillation, metolachlor is obtained. |
| category | pesticide |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 2200 mg/kg; Oral-mouse LD50: 1150 mg/kg |
| stimulation data | skin-rabbit 334 mg mild; Eye-rabbit 100 mg mild |
| flammability hazard characteristics | Combustion produces toxic nitrogen oxides and chloride gases |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | dry powder, foam, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:49:11
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View History
屠锈胺
1-((三甲硅基)乙炔基)环戊烷-1-醇
MONOHYDROGEN SODIUM PHOSPHATE
3-氯-2,4,5-三氟苯甲酸
8-氯咪唑并[1,2-A]吡嗪
山奈酚-7-O-新橘皮糖苷
N-琥珀酰亚胺基-4-((碘乙酰基)氨基)苯甲酸甲酯
异丙基苯酚磷酸酯
{2-[2-(diphenylphosphanyl)phenoxy]phenyl}diphenylphosphane
FMOC-B-叔丁基-L-丙氨酸
1-((三甲硅基)乙炔基)环戊烷-1-醇
MONOHYDROGEN SODIUM PHOSPHATE
3-氯-2,4,5-三氟苯甲酸
8-氯咪唑并[1,2-A]吡嗪
山奈酚-7-O-新橘皮糖苷
N-琥珀酰亚胺基-4-((碘乙酰基)氨基)苯甲酸甲酯
异丙基苯酚磷酸酯
{2-[2-(diphenylphosphanyl)phenoxy]phenyl}diphenylphosphane
FMOC-B-叔丁基-L-丙氨酸
Raw Materials for 屠锈胺