异五氟甲乙醚福仑
Isoflurane
CAS: 26675-46-7
Molecular Formula: C3H2ClF5O
异五氟甲乙醚福仑 - Names and Identifiers
| Name | Isoflurane |
| Synonyms | Forene Forane r-e235dal 247-897-7 Isoflurane isoflurano Isoflurane266 1-Chlor-2,2,2-trifluorethyl-difluormethylether ether,1-chloro-2,2,2-trifluoroethyldifluoromethyl 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-ethan 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane 2-chloro-2-(difluorométhoxy)-1,1,1-trifluoroéthane Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro- 1,1,1,2,4,4,5,7,7,8,10,10,11,13,13,14,14,15,15,15-icosafluoro-5,8,11-tris(trifluoromethyl)-3,6,9,12-tetraoxapentadecane |
| CAS | 26675-46-7 |
| EINECS | 247-897-7 |
| InChI | InChI=1/C14HF29O4/c15-1(2(16,17)18)44-12(38,39)4(21,8(27,28)29)46-14(42,43)6(23,10(33,34)35)47-13(40,41)5(22,9(30,31)32)45-11(36,37)3(19,20)7(24,25)26/h1H |
| InChIKey | PIWKPBJCKXDKJR-UHFFFAOYSA-N |
异五氟甲乙醚福仑 - Physico-chemical Properties
| Molecular Formula | C3H2ClF5O |
| Molar Mass | 184.49 |
| Density | 1.510 g/mL at 25 °C |
| Melting Point | 48.5°C |
| Boling Point | 48.5 °C |
| Flash Point | 48-49°C |
| Water Solubility | Soluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water. |
| Solubility | Practically insoluble in water, miscible with ethanol and trichloroethylene. |
| Vapor Presure | 238 mmHg ( 20 °C) |
| Appearance | neat |
| Specific Gravity | approximate 1.50 |
| Color | Colorless to Almost colorless |
| Merck | 14,5175 |
| BRN | 1852087 |
| Storage Condition | 2-8°C |
| Stability | Stable. |
| Refractive Index | 1.3002 |
| Physical and Chemical Properties | Transparent colorless liquid, slightly ether odor. D4251.50. Boiling point 48.5 °c. The vapor pressure at 25 °c was 44kPa. Nd2010.3002. Stable, non-flammable and non-explosive. Easily miscible with other organic liquids. |
| Use | For all kinds of surgery, general, half body anesthesia |
异五氟甲乙醚福仑 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R67 - Vapors may cause drowsiness and dizziness R48/20 - |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 3334 |
| WGK Germany | 3 |
| RTECS | KN6799000 |
| HS Code | 2909191800 |
| Hazard Note | Flammable/Toxic |
| Toxicity | An isomer of enflurane with similar anesthetic properties. Isoflurane has less effect on myocardial function, leaving the cardiovascular system normally responsive to epinephrine or hypercarbia, and it does not cause a marked increase in seizure susceptibility. It was not widely used because of reports that it caused increases in liver neoplasms in mice, but this observation has been challenged and the compound reintroduced. |
异五氟甲乙醚福仑 - Standard
Authoritative Data Verified Data
This product is 2-chloro-2-(difluoromethoxy)-l, l, l-trifluoroethane.
Last Update：2024-01-02 23:10:35
异五氟甲乙醚福仑 - Trait
Authoritative Data Verified Data
- This product is a colorless clear liquid; Volatile, with a slight odor.
- This product is soluble in organic solvents, insoluble in water.
relative density
The relative density of this product (General 0601 pycnometer method) should be 1.495~1.510.
distillation range
The distillation range of this product (General 0611) should be 47~50°C.
refractive index
The refractive index of this product (General 0622) should be 1.2990~1.3005.
Last Update：2022-01-01 11:54:41
异五氟甲乙醚福仑 - Differential diagnosis
Authoritative Data Verified Data
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1139).
- This product shows the identification reaction of organic fluoride (General rule 0301)
Last Update：2022-01-01 11:54:41
异五氟甲乙醚福仑 - Exam
Authoritative Data Verified Data
pH
take 20ml of this product, add 20ml of water, shake for 3 minutes, separate the water layer, add 2 drops of bromocresol purple indicator solution, if yellow, add 0.01 of sodium hydroxide titration solution (0.10 mOl/L), the strain is purple; If it is purple, add 0.01 of hydrochloric acid titration solution (0.60 mol/L), and the strain is yellow.
chloride
take 15ml of this product, add 30ml of water, shake for 3 minutes, test according to the following method:(1) take 5ml of water layer, check according to law (General rule 0801), not more concentrated (0.001%) than a control solution made of standard sodium chloride solution. (2) separate 10ml of water layer, add 1 ml of potassium iodide test solution and 2 drops of starch indicator solution, and do not produce blue color.
fluoride
- use plastic appliances during Operation 6
- preparation of standard solution precision weighing sodium fluoride 105 mg dried at 0.04% °C for 4 hours, put it in a 100ml measuring flask, add water 20ml to dissolve, and then add human sodium hydroxide solution () 1.0 mL, diluted to the scale with water, shaken, as a standard stock solution (equivalent to 1mg of F per 1 ml). Take an appropriate amount of standard stock solution, use buffer solution (pH 5.25) (take llOg of sodium chloride and lg of sodium citrate, put it in a 2000ml measuring flask, add 700ml of water, shake to dissolve, carefully add 150g of sodium hydroxide, shake to dissolve, let it cool, add 450ml of glacial acetic acid and 600ml of isopropyl alcohol under shaking, dilute to scale with water, mix well, the pH value of the solution should be between 5.0 and 5.5), respectively, diluted to prepare solutions containing F1, 3, 5, and 10ug per lml.
- preparation of sample solution: take 25ml of this product for precise measurement, add 25ml of water for precise measurement, shake for 5 minutes, stand still to make stratification, and take 10ml of water layer for precise measurement, then Add 10ml of buffer solution (pH 5.25) and shake it up.
- measurement the potential values of the standard solution and the test solution were measured by taking the above standard solution and the test solution, using the calomel electrode as the reference electrode and the fluorine electrode as the selection electrode, respectively. Take the logarithmic value of the fluoride ion concentration ug/ml) as the abscissa and the potential value (mV) as the ordinate to draw a standard curve. According to the measured potential value of the test solution, the fluoride ion concentration in the test solution shall be determined from the standard curve and shall not be greater than 5ug/ml [0.001% (W/V)].
Related substances
take 1 ml of this product, put it in a 100ml measuring flask, dilute it to the scale with n-hexane, shake it well, take 5ml, put it in a 50ml measuring flask, dilute it to the scale with n-hexane, shake it well, as a test solution. Test according to Gas chromatography (General 0521). The capillary column with 2-nitroterephthalic acid modified polyethylene glycol (FFAP) as stationary liquid was used as the chromatographic column. The column temperature was 60°C, the inlet temperature was 150°C, and the electron capture detector was used, the detector temperature was 220°C. The number of theoretical plates shall not be less than 15000 based on the calculation of isoflurane peak, and the separation degree of isoflurane peak and adjacent impurity peaks shall meet the requirements. The sample solution lul was accurately measured and injected into the gas chromatograph, and the chromatogram was recorded. Calculated by area normalization method, the sum of each impurity peak area shall not be greater than 0.5% of the total peak area.
residual solvent
take an appropriate amount of this product, weigh it accurately, and dilute it with cyclohexane to make it contain about O in each lml. lg solution, as the test solution; Another acetone N, N-dimethylformamide and N-methyl pyrrolidone appropriate amount, precision weighing, cyclohexane was added to dissolve and prepare a solution containing about 0.5mg of acetone, 88g of N, N-dimethylformamide and 53g of JV-methylpyrrolidone per 1 ml as a control solution. According to the test for determination of residual solvents (General Principle 0861 third method), the capillary column with 6% cyanopropylphenyl-94% dimethylsiloxane copolymer (or similar polar) as stationary liquid is used as the column; The initial column temperature is 40°C, the temperature was maintained for 10 minutes, and the temperature was raised to 230°C at a rate of 40 * C per minute for 5 minutes; The detector temperature was 250°C; And the inlet temperature was 200°C. The number of theoretical plates shall not be less than 15000 based on the calculation of acetone peak, and the separation degree of acetone and isoflurane shall meet the requirements. Take 1ul of each of the reference solution and the test solution, respectively inject the human gas chromatograph, and record the chromatogram. According to the external standard method, the residual amount of acetone, N ,N-dimethylformamide and N-methylpyrrolidone should be calculated by peak area.
Non-volatile
Take 10ml of this product, put it in a 50°C constant weight evaporation dish, volatilize to dryness at room temperature, and dry it at 50°C for 2 hours. The remaining residue should not exceed 2.0mg.
moisture
take this product, according to the determination of moisture (General 0832 first method 1), the water content shall not exceed 0.1%.
loading capacity
take this product, according to the law inspection (General 0942), should comply with the provisions.
Last Update：2022-01-01 11:54:42
异五氟甲乙醚福仑 - Category
Authoritative Data Verified Data
inhalation of general anesthetic.
Last Update：2022-01-01 11:54:42
异五氟甲乙醚福仑 - Specifications
Authoritative Data Verified Data
100ml.
Last Update：2022-01-01 11:54:43
异五氟甲乙醚福仑 - Storage
Authoritative Data Verified Data
shade, seal, and store in a cool place.
Last Update：2022-01-01 11:54:43
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Mobile: 609-228-6898
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Product Name: Isoflurane Visit Supplier Webpage Request for quotationCAS: 26675-46-7
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View History
异五氟甲乙醚福仑
四(五氟苯基)硼酸三苯基甲酯
Diaryl Yellow GGR
反-2-,顺-6-壬二烯醛
2-甲级-4-溴苯甲酸甲酯
2-氨基-4,6-二氯嘧啶
2-(2-羟基乙亚磺酰基)乙-1-醇
BAS 05038600
5-MORPHOLINOMETHYL-3-(5-NITROFURFURYLIDENEAMINO)-2-OXAZOLIDINONE
cis-isoeugenol
四(五氟苯基)硼酸三苯基甲酯
Diaryl Yellow GGR
反-2-,顺-6-壬二烯醛
2-甲级-4-溴苯甲酸甲酯
2-氨基-4,6-二氯嘧啶
2-(2-羟基乙亚磺酰基)乙-1-醇
BAS 05038600
5-MORPHOLINOMETHYL-3-(5-NITROFURFURYLIDENEAMINO)-2-OXAZOLIDINONE
cis-isoeugenol