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Name	TOLRESTAT
Synonyms	Lorestat AY-27773 Alredase Aldredase TOLRESTAT N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine N-[[6-Methoxy-5-(trifluoromethyl)naphthalen-1-yl]thioxomethyl]-N-methylglycine
CAS	82964-04-3

Molecular Formula	C16H14F3NO3S
Molar Mass	357.35
Density	1.399±0.06 g/cm3(Predicted)
Melting Point	164-165°
Boling Point	498.1±55.0 °C(Predicted)
Solubility	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
Appearance	powder
Color	white to beige
pKa	3.49±0.10(Predicted)
Storage Condition	2-8°C
Physical and Chemical Properties	Crystallization, melting point 164-165 ℃. Tolrestat Methyl Ester: C17H16F3NO3S. Melting point 109~110 ℃.
In vivo study	Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. In 21-day diabetic rats, the estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil,respectively. Either tolrestat or sorbinil inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice.

Last Update：2024-01-02 23:10:35

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CAS: 82964-04-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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