Name | Mulberrin |
Synonyms | Kuwanon KUWANONC Mulberrin Mulberrin (Kuwanon C) 3,8-Bis(3-methyl-2-butenyl)-2',4',5,7-tetrahydroxyflavone 2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-3,8-bis(3-methyl-2-butenyl)-4H-1-benzopyran-4-one 2-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-8-((Z)-3-methyl-but-2-enyl)-3-(3-methyl-but-2-enyl)-1-benzopyran-4-one |
CAS | 62949-79-5 |
Molecular Formula | C25H26O6 |
Molar Mass | 422.47 |
Density | 1.290±0.06 g/cm3(Predicted) |
Melting Point | 153-156 °C |
Boling Point | 657.7±55.0 °C(Predicted) |
pKa | 6.70±0.40(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from mulberry branches. |
In vitro study | Mulberrin is a flavone with two isopentenyl groups at positions 3 and 8. Mulberrin is a strong inhibitor of OATP2B1 with more than 80% inhibition.Mulberrin also inhibits organic anion-transporting polypeptide (OATP)-mediated uptake of Atorvastatin, Fluvastatin, and Rosuvastatin. |
biological activity | Mulberrin effectively inhibits organic anion transport polypeptide 2B1 (OATP2B1) the uptake of estrone -3-sulfate (E3S) was mediated with an IC50 value of 1.8±1.5 μm. |
Use | for content determination/identification/pharmacological experiments. |