氯胺酮盐酸盐
ketamine hydrochloride
CAS: 1867-66-9
Molecular Formula: C13H16ClNO.ClH
氯胺酮盐酸盐 - Names and Identifiers
| Name | ketamine hydrochloride |
| Synonyms | ketalar ketaset ketavet ketanest ketavet100 Ketamine HCl ketamine hydrochloride 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone 2-(o-chlorophenyl)-2-(methylamino)cyclohexanonehydrochloride (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanonehydrochloride 2-(2-chlorophenyl)-2-(methylamino)-,hydrochloride,(+-)-cyclohexanon |
| CAS | 1867-66-9 |
| EINECS | 217-484-6 |
| InChI | InChI=1/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H |
氯胺酮盐酸盐 - Physico-chemical Properties
| Molecular Formula | C13H16ClNO.ClH |
| Molar Mass | 274.19 |
| Melting Point | 252-254°C |
| Boling Point | 363.8°C at 760 mmHg |
| Flash Point | 9℃ |
| Solubility | H2O: 200mg/mL |
| Vapor Presure | 1.76E-05mmHg at 25°C |
| Appearance | solid |
| Color | white |
| pKa | 7.5(at 25℃) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | White crystalline powder. Melting point 262-263 °c. The solubility in water was 20g/100. Soluble in hot ethanol, insoluble in ether or benzene, odorless. |
| Use | Anesthetics, mainly used in short surgical procedures, pediatric examination or diagnostic procedures, induction of anesthesia and auxiliary anesthesia |
氯胺酮盐酸盐 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | GW1400000 |
| HS Code | 2923900100 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in adult mice, rats (mg/kg): 224 ±4, 229 ±5 i.p. (Goldenthal) |
氯胺酮盐酸盐 - Standard
Authoritative Data Verified Data
This product is 2-(2-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. The content of C13H16ClNO • HCl shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
氯胺酮盐酸盐 - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless.
- This product is soluble in water, soluble in hot ethanol, insoluble in ether.
Last Update：2022-01-01 15:34:49
氯胺酮盐酸盐 - Differential diagnosis
Authoritative Data Verified Data
- take an appropriate amount of this product and add water to make a solution containing about 0401 mg per lml, and measure it by UV-Vis spectrophotometry (general rule), there is a maximum absorption at a wavelength of 269nm and 277nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 393).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:34:50
氯胺酮盐酸盐 - Exam
Authoritative Data Verified Data
acidity
take 0.10g of this product, Add 10ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 4.0~5.5.
clarity of the solution
take l.Og of this product, Add 10ml of water to dissolve, the solution should be clear; If it is turbid, compared with No. 1 turbidity standard solution (General rule 0902 first method), it should not be more concentrated.
Related substances
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make a solution containing about 0.5mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. Silica gel bonded with eighteen alkyl silanes was used as the filler; 0512 mol / L sodium heptane sulfonate solution (adjusted to pH 0.0025 with 5% acetic acid) as determined by high performance liquid chromatography (General 6.0±0.1).-Acetonitrile (40:30) as mobile phase; The detection wavelength was 220nm. The number of theoretical plates shall not be less than 4000 calculated by the gas amine ketone peak, and the separation degree between the ketamine peak and the adjacent impurity peak shall meet the requirements. 20 u1 of each of the control solution and the test solution were injected into the liquid chromatograph respectively, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.25%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (0.5%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of burning residues shall be inspected according to law (General Principles 0821, Law II) and shall not contain more than 10 parts per million of heavy metals.
Last Update：2022-01-01 15:34:50
氯胺酮盐酸盐 - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add glacial acetic acid 40ml and acetic anhydride 10ml ultrasonic to dissolve, let cool, according to the potential titration method (General 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol /L) corresponds to 27.42mg of C13H16ClNO. HCl.
Last Update：2022-01-01 15:34:51
氯胺酮盐酸盐 - Category
Authoritative Data Verified Data
intravenous general anesthetic.
Last Update：2022-01-01 15:34:51
氯胺酮盐酸盐 - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 15:34:51
氯胺酮盐酸盐 - Ketamine Hydrochloride Injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of ketamine hydrochloride. Ketamine-containing (C13H16ClNO) shall be between 90.0% and 110.0% of the labeled amount.
trait
This product is a clear colorless liquid.
identification
- Take 2 drops of this product, add 4ml of 0.5% sulfuric acid solution and 1 drop of bismuth potassium iodide solution, and generate red-brown precipitate.
- taking an appropriate amount of this product, according to the identification (1) Test under the item of ketamine hydrochloride, the same results were shown.
examination
- the pH value should be 3.5 to 0631 (general).
- Related Substances: dilute the product with mobile phase to make a solution containing 0.5mg of ketamine hydrochloride per 1ml as a test solution; Take 1ml for precision measurement and place it in a 200 ml volumetric flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.25%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).
- bacterial endotoxin this product, according to the law to check (General 1143), each 1 mg of ketamine hydrochloride containing endotoxin should be less than 0.40 EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take an appropriate amount of this product (about 25mg of hydrochloric acid), put it in a measuring flask, dilute it to the mark with 0.05mol / L hydrochloric acid solution, and shake it well, as a test solution; Another reference substance of ketamine hydrochloride was precision weighed, dissolved and quantitatively diluted with 0.05mol / L hydrochloric acid solution to make a solution containing about 0.25mg of ketamine hydrochloride per 1 ml, as a control solution. The above two kinds of solutions were taken, and the absorbance was measured at the wavelength of 0401 nm by ultraviolet-visible spectrophotometry (general rule), and calculated.
category
with ketamine hydrochloride.
specification
(l ) 2ml:0.lg (2) 10ml:0.lg (3)20ml:0.2g
storage
sealed storage.
Last Update：2022-01-01 15:34:52
氯胺酮盐酸盐 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Intravenous general anesthetic | Ketamine hydrochloride (ketamine hydrochloride) is a kind of intravenous general anesthetic, which is a non-barbiturate intravenous anesthetic. It is odorless white crystalline powder at room temperature, soluble in water, dissolved in hot ethanol, and insoluble in ether or benzene. It has anesthetic and analgesic effects. Due to the short anesthetic time and hallucinations of this product, some people in the society use it as a drug. Now the country has classified it as a class of psychotropic drugs for monitoring and management. similar drugs: ketamine hydrochloride |
| use | this product is a new type of non-barbiturate intravenous anesthetic with excellent analgesic effect. Soon after vein or muscle shooting, confusion appears, such as entering a dream, showing a light sleep state. The clinical manifestation was shallow general anesthesia. This product is injected intravenously for about one minute and lasts for about 10 minutes. When a larger substance is described, the dosage can be added continuously. Mainly used for surgical short hand description, pediatric examination or diagnostic operations, anesthesia induction and auxiliary anesthesia. |
| Production method | Dissolve the newly prepared 1-bromocyclopentyl-o-chlorobenzophenone in methylamine solution to obtain 1-hydroxycyclopentyl-o-chlorophenyl-N-methamine, dissolve it in decalin, refluxing for 2.5 hours, evaporating decalin under reduced pressure, extracting the residue with dilute hydrochloric acid, decolorizing with activated carbon, and adjusting with alkali to alkaline, and ketamine base ([6740-88-1], melting point 92-93 ℃), recrystallized from pentane-ether to make ketamine hydrochloride. The intermediate 1-bromocyclopentyl-o-chlorobenzophenone is obtained by chlorination of o-chlorobenzoic acid, addition to cyclopentene, and then bromination. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral administration-rat LD50 447 mg/kg; Oral administration-mouse LD50: 617 mg/kg |
| flammability hazard characteristics | flammability; fire scene decomposition of toxic nitrogen oxides and chloride smoke |
| storage and transportation characteristics | warehouse is low temperature, ventilated and dry; Store separately from food raw materials |
| fire extinguishing agent | water, carbon dioxide, dry powder, sand |
Last Update：2024-04-09 15:16:48
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Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
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Product Name: ketamine hydrochloride Request for quotation
CAS: 1867-66-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
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CAS: 1867-66-9
Tel: 0086-551-65418684
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Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
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View History
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