Molecular Formula | C43H75NO16 |
Molar Mass | 862.05 |
Density | 1.1417 (rough estimate) |
Melting Point | 219-224 C |
Boling Point | 778.19°C (rough estimate) |
Flash Point | >110°(230°F) |
Water Solubility | Freely soluble in organic solvents, practically insoluble in water |
Solubility | ethanol: soluble50mg/mL |
Vapor Presure | 4.94E-31mmHg at 25°C |
Appearance | solid |
Color | white |
pKa | 13.09±0.70(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Stability | Hygroscopic |
Refractive Index | 1.5280 (estimate) |
Physical and Chemical Properties | Appearance: white crystalline powder, tasteless |
Use | Is an antibiotic drug, mainly used for penicillin-resistant Staphylococcus infections |
In vitro study | Erythromycin against Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Neisseria gonorrhoeae, Campylobacter jejuni, Helicobacter pylori, and Borrelia burgtori both have antibacterial activity. Erythromycin is a motilin receptor agonist, which is a potent agonist of gastrointestinal muscle activity. Erythromycin induced a 50% maximal contractile response to an ultra-high dose of acetylcholine, the concentration required being 2 μm. Instead of 50% of the labeled motilin, the required concentration of Erythromycin is 13 μm. Erythromycin has no effect on muscle strips of rat or dog duodenum, but induces contraction of human muscle strips. |
Risk Codes | R42/43 - May cause sensitization by inhalation and skin contact. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 2 |
RTECS | WM9800000 |
HS Code | 29419000 |
Toxicity | LD50 oral in mouse: > 10gm/kg |
Raw Materials | Succinic anhydride Erythromycin Tetrahydrofuran |