盐酸氯丙那林(盐酸氯喘)
Clorprenaline HCL
CAS: 6933-90-0
Molecular Formula: C11H17Cl2NO
盐酸氯丙那林(盐酸氯喘) - Names and Identifiers
盐酸氯丙那林(盐酸氯喘) - Physico-chemical Properties
| Molecular Formula | C11H17Cl2NO |
| Molar Mass | 250.16 |
| Melting Point | 162-167oC |
| Boling Point | 329.7°C at 760 mmHg |
| Flash Point | 153.2°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 6.99E-05mmHg at 25°C |
| Appearance | Solid |
| Color | White to Pale Yellow |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Hygroscopic |
| Use | For the treatment of bronchial asthma |
| In vitro study | 8.0-1.6 × 10 Clorprenaline is a bronchodilator, according to affinity interactions, isolated by CE, or using a charged CD-CZE, sulfobuhylether (SBE)-β-CD or β-CD-phosphate, with a resolution greater than 1.2. Clorprenaline was isolated in optimal conditions at 60 mM HP-β-CD. Clorprenaline hydrochloride (a), Bromhexine hydrochloride (B) and Decloxizine hydrochloride (c) are the three main components of Clorprenaline compound tablets. |
盐酸氯丙那林(盐酸氯喘) - Standard
Authoritative Data Verified Data
This product is (-a-(1-methylethyl) amino] methyl]-2-chlorophenylmethanol hydrochloride. The content of C11H16C1NO • HC1 shall not be less than 98.5% calculated as dry product.
Last Update：2024-01-02 23:10:35
盐酸氯丙那林(盐酸氯喘) - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless.
- This product is soluble in water or ethanol, dissolved in chloroform, slightly soluble in acetone, insoluble in ether.
melting point
The melting point of this product (General 0612) is 165~169°C.
Last Update：2022-01-01 15:34:35
盐酸氯丙那林(盐酸氯喘) - Differential diagnosis
Authoritative Data Verified Data
- take 1ml of 1% aqueous solution of this product, add 20% sulfuric acid to make potassium permanganate saturated solution 5ml, shake for several minutes, add appropriate amount of oxalic acid, shake well, make the solution clear, add water 5ml, add dinitrophenylhydrazine solution, namely precipitation.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 655).
- This product chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:34:36
盐酸氯丙那林(盐酸氯喘) - Exam
Authoritative Data Verified Data
Related substances
take an appropriate amount of this product, add the mobile phase and dilute it to make a solution containing lmg per lml as a test solution; Take lml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the test of high performance liquid chromatography (General 0512), silica gel bonded with eighteen alkyl silane as filler; Acetonitrile-water-triethylamine (10:90:1)(With phosphoric acid to adjust the pH value to 3.0) as mobile phase; The detection wavelength was 212nm. The number of theoretical plates shall not be less than 3 000 calculated according to the gas propanarin peak, and the separation degree between the chlorprenarin peak and the adjacent impurity peaks shall meet the requirements. Take 10 u1 of the test solution and the control solution respectively, inject the human liquid chromatograph, record the chromatogram to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 15:34:36
盐酸氯丙那林(盐酸氯喘) - Content determination
Authoritative Data Verified Data
take about 0.15g of this product, precision weighing, add glacial acetic acid 20ml, if necessary, slightly warm to dissolve, add mercury acetate test solution 3ml and crystal violet indicator solution 1 drop, with high gas acid titration solution (0.1 mol/ L) was titrated to blue-green, and the results of the titration were corrected with a blank test. Per 1 ml of perchloric acid titration solution (0.1 mol/ L corresponds to 25.02mg of C11H16ClNO. HCI.
Last Update：2022-01-01 15:34:37
盐酸氯丙那林(盐酸氯喘) - Category
Authoritative Data Verified Data
B adrenergic receptor agonists.
Last Update：2022-01-01 15:34:37
盐酸氯丙那林(盐酸氯喘) - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:34:37
盐酸氯丙那林(盐酸氯喘) - Chlorprenaline hydrochloride tablets
Authoritative Data Verified Data
This product contains hydrochloric acid gas prenaline (C11H16C1N0 • HCl) should be 90.0% ~ 110.0% of the label amount.
trait
This product is white tablet.
identification
take an appropriate amount of fine powder of this product (about 50mg equivalent to chlorpromazine hydrochloride), add 5ml of water, stir to dissolve paracrine hydrochloride, filter, filtrate under the identification of chlorpromazine hydrochloride (1), (3) the test showed the same reaction.
examination
- relevant substances: take an appropriate amount of fine powder of this product (about 25mg of chlorprenaline hydrochloride), put it in a 25ml measuring flask, add an appropriate amount of mobile phase, and sonicate the gas-containing proprenaline hydrochloride to dissolve, and let it cool, dilute to the scale with mobile phase, shake, filter, and take the continued filtrate as the test solution; Take an appropriate amount with precision and make a quantitative dilution with mobile phase to prepare a solution containing 10ug of chlorpromazine hydrochloride per lml, as a control solution. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0%), the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution
- Content uniformity take 1 tablet of this product, put it in 50ml measuring flask, add mobile phase, shake to dissolve the hydrochloric acid, dilute to the scale with mobile phase, shake, filter, the continued filtrate was taken as the test solution. Determination of content according to the method under the content determination item, should comply with the provisions (General 0941).
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Acetonitrile-water triethylamine (10:90:1)(pH adjusted with phosphoric acid (3.0) as mobile phase; the detection wavelength was 212nm. The degree of separation between the chlorprenaline peak and the adjacent impurity peak shall meet the requirements.
- determination Method: Take 20 tablets of this product, precise weighing, fine grinding, precise weighing to take an appropriate amount (about 10mg equivalent to gasalene hydrochloride), and put it in a 100ml measuring flask, add mobile phase to shake to dissolve paracrine hydrochloride, dilute to scale with mobile phase, shake, filter, and take the continued filtrate as the test solution; Take 10ul with precision, human liquid chromatograph was used and the chromatogram was recorded. In addition, take about 10mg of the reference substance of chlorprenaline hydrochloride, weigh it accurately, put it in a 100ml measuring flask, add the mobile phase to shake to dissolve, dilute it to the scale with the mobile phase, shake it well, and use it as the reference solution. According to the external standard method to calculate the peak area, that is.
category
Same as chlorpromazine hydrochloride.
specification
5mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:34:38
盐酸氯丙那林(盐酸氯喘) - Reference Information
| Overview | clorprenaline hydrochloride (CLP), chemical name α-[ [(1-methylethyl)] amino] methyl]-2-chloro-benzyl alcohol hydrochloride, a beta-adrenergic receptor agonist. Clinical commonly used in the treatment of bronchial asthma, bronchitis and other respiratory diseases. As a feed additive, it also has the function of nutrient redistribution when feeding animals, which can significantly accelerate the growth rate of animals, improve the lean meat rate of ketone bodies and reduce the fat rate. It is a common substitute for "Clenbuterol" at present. Figure 1 shows the results of |
| drug interaction | 1. The drug with epinephrine and isoproterenol and other catecholamines and when will cause arrhythmias, increased heart rate, it should be avoided with the above drugs. 2. This product has the effect of inhibiting the skin reaction caused by allergy, so the effect of this drug on the reaction should be considered when evaluating the skin test reaction. 3. With the expansion of other bronchial β2 receptor agonists have an additive effect, but also increased adverse reactions. 4. Avoid simultaneous use with monoamine oxidase inhibitors and tricyclic antidepressants. With anticholinergic drugs or theophylline drugs used together, its expansion of the bronchi, asthma relief effect enhancement. |
| Application | 1. Can be used for bronchial asthma, asthmatic bronchitis, chronic bronchitis with emphysema, can relieve asthma and improve lung function. 2. As a feed additive, it also has the function of nutrient redistribution when feeding animals, which can significantly accelerate the growth rate of animals, improve the lean meat rate of ketone bodies and reduce the fat rate. It is a common substitute for "Clenbuterol. (2016-01-13) |
| note | 1. Arrhythmia, hypertension, hyperthyroidism, diabetes and prostatic hyperplasia caused by dysuria patients with caution. 2. Please ask a physician or pharmacist for Counseling of the dosage for children. 3. Must be taken according to the recommended dose, not excessive use. 4. Allergic to this product is contraindicated, allergies are used with caution. 5. The use of this product is prohibited when the character is changed. 6. Please keep this product out of contact with children. 7. Children must use under adult supervision. |
| biological activity | Clorprenaline HCl (NSC 334693) is a β2-receptor agonist with a significant bronchodilator effect. |
| Target | Value |
| Use | for the treatment of bronchial asthma |
Last Update：2024-04-09 21:21:28
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CAS: 6933-90-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
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WhatsApp: +8613651600618
Product Name: Clorprenaline Hydrochloride Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple Specifications
Product Name: Clorprenaline Hydrochloride Visit Supplier Webpage Request for quotationCAS: 6933-90-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Clorprenaline hydrochloride Request for quotation
CAS: 6933-90-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 6933-90-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
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