磷酸肌酸钠盐
Creatine phosphate disodium salt
CAS: 922-32-7
Molecular Formula: C4H11N3NaO5P
磷酸肌酸钠盐 - Names and Identifiers
| Name | Creatine phosphate disodium salt |
| Synonyms | SODIUM PHOSPHOCREATINE Creatine Phosphate Sodium Disodium Creatinephosphate Creatine phosphate sodium salt Creatine phosphate disodium salt Creatine phosphoric acid,sodium salt CREATINE PHOSPHATE SODIUM FOR LNJECTION Creatine phosphate disodium salt and Intermediates N-[Imino(phosphonoamino)methyl]-N-methylglycine, disodium salt {[(1E)-amino(phosphonatoamino)methylidene](methyl)ammonio}acetate SodiuM 2-(1-Methylguanidino)acetate hydrogenphosphate tetrahydrate DISODIUM [(CARBOXYMETHYL)(METHYL)AMINO](IMINO)METHYLAMIDOPHOSPHATE Phosphocreatine Sodium SaltCreatine Phosphate Sodium SaltSodium Phosphocreatine |
| CAS | 922-32-7 |
| EINECS | 213-074-6 |
| InChI | InChI=1/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H5,5,6,8,9,10,11,12)/p-2 |
| InChIKey | HUWYWJSJJDCZRQ-UHFFFAOYSA-L |
磷酸肌酸钠盐 - Physico-chemical Properties
| Molecular Formula | C4H11N3NaO5P |
| Molar Mass | 235.11 |
| Density | 1.784 at 20℃ |
| Water Solubility | soluble |
| Solubility | H2O: 0.1g/mL, clear, colorless |
| Vapor Presure | 0.025Pa at 20-50℃ |
| Appearance | White powder |
| Color | White |
| PH | pH : 8.3 (20% in water) |
| Storage Condition | Inert atmosphere,2-8°C |
| MDL | MFCD00150192 |
| Physical and Chemical Properties | Appearance: white powder |
| Use | Used as a Biochemical reagent |
磷酸肌酸钠盐 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29252900 |
磷酸肌酸钠盐 - Introduction
Soluble in water.
Last Update：2022-10-16 17:30:11
磷酸肌酸钠盐 - Reference Information
| LogP | -1.17 at 22℃ and pH7 |
| surface tension | 68.63mN/m at 1.034g/L and 20 ℃ |
| Application | creatine phosphate is an important energy supplying substance in muscle contraction metabolism, which is the chemical energy reserve of smooth muscle and striated muscle, and for the re-synthesis of ATP. phosphocreatine diisodium is its medicinal form. Creatine phosphate sodium, can be used as a myocardial protective agent, in the body to play a variety of important physiological effects in the form of creatine phosphate, is widely used in cardiac ischemia or cardiac surgery in patients with myocardial protection, and heart failure, myocardial infarction and arrhythmia and other cardiovascular disease treatment. It can improve cardiac function and heart rate variability in patients with ischemic cardiomyopathy, not only can provide energy for myocardial cells when suffering from ischemia and hypoxia, it can also protect the myocardial cell membrane from the invasion of oxygen free radicals and other harmful substances to protect the myocardium of patients with cardiac insufficiency after operation, which is beneficial to the recovery of cardiac function of patients with cardiac insufficiency after operation. Its comprehensive treatment of myocardial damage after neonatal asphyxia, can significantly improve the myocardial enzymes and ECG, with good efficacy and safety. |
| action characteristics | This product is the chemical energy reserve of cardiac muscle and skeletal muscle, and is used for the re-synthesis of ATP, provides energy for the process of actomyosin contraction and plays an important role in the energy metabolism of muscle contraction. Insufficient energy supply is an important factor in the formation and development of myocardial cell injury. 1. It has a significant protective effect on the systolic function of ischemic myocardium, so that the contractility is fully restored and the diastolic pressure decreases rapidly. 2. Maintain the content of adenosine triphosphate and creatine phosphate in the cells, and maintain the myocardial energy reserve. 3. Reduce the loss of creatine kinase, reduce cell membrane damage. 4. Anti-oxidative properties. 5. Improve the microcirculation of the myocardium. Due to the existence of high-energy phosphate bonds in phosphocreatine molecules, the high-energy phosphate bonds directly convert ADP into ATP under the action of phosphocreatinase, and the energy directly to the body can act immediately. Fructose diphosphate, as an intermediate product of glycolysis, needs to act indirectly through anaerobic metabolism. |
| synthesis | dibenzyloxyphosphoryl chloride (2) was obtained from dibenzyl phosphate and oxalyl chloride, dibenzyloxyphosphoryl creatine ethyl ester obtained by reaction with creatine ethyl ester hydrochloride in the presence of triethylamine is cycled to dibenzyloxyphosphoryl creatinine (3),3 by Palladium carbon catalytic hydrogen free benzyl reaction with sodium hydroxide to phosphate creatinine disodium (4),4 in the role of sodium hydroxide water solution 1. Figure 1 is the synthetic route of creatine phosphate sodium |
| Use | is suitable for the protection of abnormal myocardial metabolism under myocardial ischemia. biochemical studies detection of creatine kinase substrate |
| adverse reactions, contraindications and drug effects | ; high dose (5~10g/d) is prohibited for patients with chronic renal insufficiency. Rapid intravenous injection of more than 1g can cause blood pressure reduction. High dose administration results in a large amount of phosphate intake, which can affect calcium metabolism and the secretion of hormones that regulate homeostasis, and affect renal function and purine metabolism.
Last Update：2024-04-09 21:54:55
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