舒巴坦纳
Sulbactam sodium
CAS: 69388-84-7
Molecular Formula: C8H12NNaO5S
舒巴坦纳 - Names and Identifiers
| Name | Sulbactam sodium |
| Synonyms | CP-458992 Combactam Sulbatam Sodium SODIUM SULBACTAM Sulbactam sodium SULBACTAM SODIUM SULBACTAM SODIUM SALT sodium 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide sodium (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide (2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]heptane-2-carboxylic acid 4,4-dioxide sodium salt (2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium salt 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S,5R)- (9CI) |
| CAS | 69388-84-7 |
| EINECS | 273-984-4 |
| InChI | InChI=1/C8H11NO5S.Na/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14;/h5-6H,3H2,1-2H3,(H,11,12);/q;+1/t5-,6+;/m1./s1 |
| InChIKey | NKZMPZCWBSWAOX-IBTYICNHSA-M |
舒巴坦纳 - Physico-chemical Properties
| Molecular Formula | C8H12NNaO5S |
| Molar Mass | 257.24 |
| Melting Point | >230°C (dec.) |
| Solubility | Freely soluble in water, sparingly soluble in ethyl acetate, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute acids. |
| Appearance | neat |
| Color | White |
| Storage Condition | -20°C Freezer, Under Inert Atmosphere |
| Use | For beta-lactamase inhibitors |
| In vitro study | Ampicillin-Sulbactam has a wide range of antibacterial activity that includes Gram-positive and Gram-negative aerobic and anaerobic bacteria. |
舒巴坦纳 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 42/43 - May cause sensitization by inhalation and skin contact. |
| Safety Description | S22 - Do not breathe dust. S24 - Avoid contact with skin. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. |
| HS Code | 29349990 |
| Toxicity | LD50 ivn-rat: 6500 mg/kg NKRZAZ 32(Suppl 4),97,84 |
舒巴坦纳 - Upstream Downstream Industry
| Raw Materials | SALBACTAM ACID Sodium 2-ethylhexanoate |
舒巴坦纳 - Nature
Open Data Verified Data
a white crystalline solid having a melting point of 148 to 151 ° C. A melting point of 154 to 155 ° C. (decomposition) or 170 ° C. (decomposition) has also been reported. Soluble in water.
Sulbactam sodium: Ca Hio NNaOs S,CAS accession number [69388-84-7]. White or off-white crystalline powder, soluble in water.
Last Update：2024-01-02 23:10:35
舒巴坦纳 - Quality standards-Chinese Pharmacopoeia 2005 edition
Open Data Verified Data
sulbactam Sodium: the content of sulbactam (Cs Hn NNaOs S) should not be less than 88, calculated as anhydrous. 6%; Water content shall not exceed 1.0%; Crystallinity shall comply with the provisions; Containing heavy metals shall not exceed 0.002%; Sterility shall comply with the provisions.
Last Update：2022-01-01 08:52:34
舒巴坦纳 - Preparation Method
Open Data Verified Data
sodium penicillanic acid was used as raw material. Potassium permanganate was dissolved in water and glacial acetic acid, an aqueous solution of sodium penicillanic acid was added thereto, stirred, the cooling bath was removed, solid sodium bisulfite was added until the color of potassium permanganate disappeared, and then filtered. A saturated aqueous solution of sodium chloride was added to the filtrate to adjust the pH to 1.7. The acidic aqueous solution was extracted with ethyl caproate. After drying and concentration, sulbactam was obtained. Alternatively, 6-APA is used as the raw material. To a mixture of sodium bromide and sulfuric acid, 6-APA was added. After 6-APA was completely dissolved, an aqueous solution of sodium nitrite was added dropwise. After completion of the reaction, the aqueous layer was separated and extracted with dichloromethane. The oil was extracted from the extract and washed with water. Water is added and neutralized to neutral, and an aqueous solution containing 6 Bromo penicillanic acid is separated out, and a mixed solution of potassium permanganate, water and glacial acetic acid is added to react at 5 ℃ or lower. Thereafter, sodium bisulfite was added to decolorize, chloroform was added, and the pH was adjusted to 2 with sulfuric acid. The chloroform layer was separated and the aqueous layer was extracted with chloroform. The chloroform layers were combined, washed with water and dried. The chloroform was distilled off under reduced pressure to precipitate crystals, washed with chloroform, and dried to obtain 6-bromopenicillane sulfone acid. 6. Combine with water, adjust to Neutral with sodium hydroxide, add palladium-carbon and disodium hydrogen phosphate, hydrogenolysis, filter, add ethyl acetate to filtrate, The pH was adjusted to 2 with sulfuric acid. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, washed with water, dried and concentrated under reduced pressure to obtain yellowish crystals, which were washed with ethyl acetate and dried under vacuum to obtain sulbactam
.Last Update：2022-01-01 08:52:34
舒巴坦纳 - Use
Open Data Verified Data
sulbactam is an irreversible competitive β-lactamase inhibitor, which can inhibit β-lactamase produced by Gram-positive and negative bacteria (except Pseudomonas aeruginosa), the irreversible reaction with the enzyme inactivates the enzyme, and the activity of the enzyme cannot be restored after the inhibitor is removed. Its antibacterial activity is very weak, so it is rarely used alone, often used in combination with other lactam antibiotics, there is a significant synergistic effect, the majority of resistant bacteria are effective. And cefoperazone compound preparation for the treatment of infections of drug-resistant bacteria; And ampicillin compound preparation compound ampicillin.
Last Update：2022-01-01 08:52:35
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CAS: 69388-84-7
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CAS: 69388-84-7
Tel: 17505222756
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Product Name: Sulbactam sodium Request for quotation
CAS: 69388-84-7
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Raw Materials for 舒巴坦纳