舒拉明钠
Suramin sodium salt
CAS: 129-46-4
Molecular Formula: C51H34N6Na6O23S6
舒拉明钠 - Names and Identifiers
| Name | Suramin sodium salt |
| Synonyms | SURAMIN reasodiumsalt sodiumsuramin Suramin sodium Suramin sodium salt Suramin hexasodium salt 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfoni |
| CAS | 129-46-4 |
| EINECS | 204-949-3 |
舒拉明钠 - Physico-chemical Properties
| Molecular Formula | C51H34N6Na6O23S6 |
| Molar Mass | 1429.17 |
| Melting Point | >260°C (dec.) |
| Water Solubility | soluble |
| Solubility | H2O: >10mg/mL |
| Appearance | Morphological Crystalline Powder |
| Color | White |
| BRN | 3694087 |
| PH | pH(10g/l, 25℃) : 5.0～8.0 |
| Storage Condition | 0-6°C |
| Stability | Hygroscopic |
| Physical and Chemical Properties | Bioactive Suramin sodium hexasodium (Suramin) is a reversible and competitive protein tyrosine phosphatase (PTPases) inhibitor. Suramin sodium salt is a potent sirtuins inhibitor: SirT1 (IC50=297 nM),SirT2 (IC50=1.15 μM),SirT5 (IC50=22 μM). Suramin sodium salt is a competitive reverse transcriptase inhibitor (DNA topoisomerase II: IC50 = 5 μM). Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor. Suramin sodium salt effectively inhibits IP5K and is an antiparasitic (antiparasitic), antitumor and antiangiogenic agent. |
| Use | The application of suramin sodium has been proved to have anti-trypanosomiasis, anti-tumor, prevention and treatment of ocular proliferative diseases, anti-virus, immunomodulatory effects, and widely used in clinical practice. At present, there is no report that suramin sodium has anti-coccidia effect. Through the known properties of suramin sodium, it is impossible to infer whether it has anti-coccidia effect. Suramin sodium salt, is a hepatitis C virus NS3 helicase inhibitor. It is also used to treat arthritis caused by collagen problems. |
舒拉明钠 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | QM7000000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29242998 |
| Toxicity | LD50 in mice (mg/kg): ~620 i.v. (Hawking) |
舒拉明钠 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.7 ml | 3.499 ml | 6.997 ml |
| 5 mM | 0.14 ml | 0.7 ml | 1.399 ml |
| 10 mM | 0.07 ml | 0.35 ml | 0.7 ml |
| 5 mM | 0.014 ml | 0.07 ml | 0.14 ml |
Last Update：2024-01-02 23:10:35
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Multiple SpecificationsSpot supply
Product Name: Suramin hexasodium salt Visit Supplier Webpage Request for quotationCAS: 129-46-4
Tel: 609-228-6898
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tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: Suramin hexasodium salt Visit Supplier Webpage Request for quotationCAS: 129-46-4
Tel: +86-400-900-4166
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Mobile: +86-18621343501
QQ: 2881950922
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Product Name: Suramin hexasodium salt Visit Supplier Webpage Request for quotationCAS: 129-46-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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View History
舒拉明钠
(R)-(+)-2-CHLOROPROPIONIC ACID METHYL ESTER
Ammonium hexachloroiridate(IV)
CAPRYLYL CHLORIDE
RARECHEM AL BW 0007
EVANS BLUE C.I. No 23860
2-氯-4-叔戊基苯酚
6-乙炔基-4,4-二甲基硫代色满
4-环丙基苯乙酸乙酯
烯丙基甲基碳酸酯
(R)-(+)-2-CHLOROPROPIONIC ACID METHYL ESTER
Ammonium hexachloroiridate(IV)
CAPRYLYL CHLORIDE
RARECHEM AL BW 0007
EVANS BLUE C.I. No 23860
2-氯-4-叔戊基苯酚
6-乙炔基-4,4-二甲基硫代色满
4-环丙基苯乙酸乙酯
烯丙基甲基碳酸酯