葡萄糖甲胺
N-Methyl-D-glucamine
CAS: 6284-40-8
Molecular Formula: C7H17NO5
葡萄糖甲胺 - Names and Identifiers
| Name | N-Methyl-D-glucamine |
| Synonyms | Meglumin Meglumine Methylglucamin Methylglucamine n-methylglucamine N-Methyl-D-glucamine D(-)-N-METHYLGLUCAMINE 1-Deoxy-1-(methylamino)hexitol 1-deoxy-1-(methylamino)hexitol 1-deoxy-1-methylamino-D-glucitol 1-deoxy-1-(methylamino)-d-glucito 1-deoxy-1-(methylammonio)-D-allitol 1-deoxy-1-(methylammonio)-D-glucitol 1-deoxy-1-(methylammonio)-D-altritol D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)- 1-deoxy-1-(methylammonio)-D-mannitol Glucitol, 1-deoxy-1-(methylamino)-, D- |
| CAS | 6284-40-8 |
| EINECS | 228-506-9 |
| InChI | InChI=1/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/p+1/t4-,5-,6+,7-/m1/s1 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
葡萄糖甲胺 - Physico-chemical Properties
| Molecular Formula | C7H17NO5 |
| Molar Mass | 195.21 |
| Density | 1.2669 (rough estimate) |
| Melting Point | 129-131.5 °C (lit.) |
| Boling Point | 331.88°C (rough estimate) |
| Specific Rotation(α) | -16.5 º (c=10, H2O, on dry sub) |
| Flash Point | 251.6°C |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Solubility | Soluble in water, slightly soluble in ethanol, solubility: 100G/100 ML of water (25°C), 1.2G/100 ML of ethanol (25°C),21G/100 ML of ethanol (70°C). Almost insoluble in chloroform, |
| Vapor Presure | 1.12E-11mmHg at 25°C |
| Appearance | White crystal |
| Color | White to almost white |
| Merck | 14,6078 |
| BRN | 385906 |
| pKa | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| PH | 11 (10g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Sensitive | Air Sensitive & Hygroscopic |
| Refractive Index | -16.5 ° (C=2, H2O) |
| MDL | MFCD00004707 |
| Physical and Chemical Properties | Melting point 128-132°C specific optical rotation -16.5 ° (c = 10, H2O, on dry sub) water-soluble 100g/100 mL (25°C) |
| Use | Diagnostic agents, cosolvents for contrast media, surfactants |
葡萄糖甲胺 - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | LZ4295770 |
| FLUKA BRAND F CODES | 3-10-23 |
| TSCA | Yes |
| HS Code | 29221980 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
葡萄糖甲胺 - Introduction
The taste is slightly sweet and salty.
Last Update：2022-10-16 17:27:25
葡萄糖甲胺 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | meglumine selecting a suitable balance for the drug is particularly important for improving the solubility and bioavailability of the drug. Meglumine (N-methyl-D-glucosamine, Meglumine) is a balance ion that is widely used to improve the solubility of drugs. It is an amino sugar of sorbitol origin with a pKa value of 9.6. |
| Use | as a cosolvent and surfactant for contrast agents. Diagnostic agents, as cosolvents for contrast agents and Diagnostic agents, cosolvents and surfactants for contrast agents biochemical studies |
| production method | is obtained by condensation of glucose with monomethylamine followed by catalytic hydrogenation. Anhydrous ethanol and dry glucose were added to the reaction pot, and the dry monomethylamine gas was introduced at 50 ℃. After 1.5-2H of reaction, the solution was gradually clarified and kept at 50 ℃ for 2H, A solution of glucose in methylamine was obtained. It was then added to the autoclave and pressurized to 2.5MPa with hydrogen in the presence of rexler's nickel and stirred for 1-2H at 80-85 °c. Then, after cooling and depressurization, the material is discharged, the upper meglumine ethanol solution is cooled and crystallized, filtered to obtain the crude product of meglumine, and then refined to obtain the finished product. |
| autoignition temperature | ~ 662 F |
Last Update：2024-04-10 22:29:15
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View History
葡萄糖甲胺
1-ACETAMINO ADAMANTANE
5-CHLORO-3-IODO-1H-INDAZOLE
4-METHYL-1-ACETONAPHTONE
氨基胍
(R)-3-[(甲基磺酰基)氧基]吡咯烷-1-羧酸叔丁酯
2142-01-0
1-ACETAMINO ADAMANTANE
5-CHLORO-3-IODO-1H-INDAZOLE
4-METHYL-1-ACETONAPHTONE
氨基胍
(R)-3-[(甲基磺酰基)氧基]吡咯烷-1-羧酸叔丁酯
2142-01-0