葫蔓藤碱甲
Gelsenicine
CAS: 82354-38-9
Molecular Formula: C19H22N2O3
葫蔓藤碱甲 - Names and Identifiers
| Name | Gelsenicine |
| Synonyms | Gelsenicine humantenmine Spiro[3H-indole-3,7'(6'H)-[3,6]methano[3H]oxepino[4,3-b]pyrrol]-2(1H)-one, 2'-ethyl-3'a,4',8',8'a-tetrahydro-1-methoxy-, (3S,3'R,3'aS,6'R,8'aS)- |
| CAS | 82354-38-9 |
葫蔓藤碱甲 - Physico-chemical Properties
| Molecular Formula | C19H22N2O3 |
| Molar Mass | 326.39 |
| Density | 1.44±0.1 g/cm3(Predicted) |
| Boling Point | 463.6±55.0 °C(Predicted) |
| pKa | 7.17±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | Humantenmine (HMT) decreases the 14-day survival rate of the mice to 17% after they are intragastrically treated with HMT, along with hepatic injury and increasing alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels. CYP3A4/5 mediates the metabolism and detoxification of HMT. |
葫蔓藤碱甲 - Reference
| Reference Show more | 1. [IF=5.81] Rongcai Yue et al."Sempervirine Inhibits Proliferation and Promotes Apoptosis by Regulating Wnt/β-Catenin Pathway in Human Hepatocellular Carcinoma."Front Pharmacol. 2021 Dec 7;12:806091 |
葫蔓藤碱甲 - Introduction
Gelsenicine (also known as Open Eye, Gelsic acid) is an organic compound with a chemical formula of C11H12O3. It is a colorless crystalline powder, soluble in organic solvents such as alcohols and ethers, and slightly soluble in water.
Gelsenicine has some pharmacological activities, such as antioxidant and anti-inflammatory effects, can prevent platelet aggregation and platelet adhesion, and has a certain protective effect on cardiovascular and cerebrovascular diseases. It is also being studied for the treatment of tumors and in the antiviral field.
Gelsenicine is generally prepared by natural plant extraction or artificial synthesis. Natural sources include Gelomiaceae, Cotoneaster, etc. The synthetic method can be obtained by chemical synthesis reaction.
When using Gelsenicine, you need to pay attention to the following safety information: It is a chemical substance that may cause certain harm to the human body. In the process of operation, attention should be paid to avoid direct contact with the skin and inhalation of its dust, to avoid ingestion or misuse. At the same time, the general operating specifications for chemicals, such as wearing protective gloves and glasses, should be observed, and the working environment should be well ventilated.
Gelsenicine has some pharmacological activities, such as antioxidant and anti-inflammatory effects, can prevent platelet aggregation and platelet adhesion, and has a certain protective effect on cardiovascular and cerebrovascular diseases. It is also being studied for the treatment of tumors and in the antiviral field.
Gelsenicine is generally prepared by natural plant extraction or artificial synthesis. Natural sources include Gelomiaceae, Cotoneaster, etc. The synthetic method can be obtained by chemical synthesis reaction.
When using Gelsenicine, you need to pay attention to the following safety information: It is a chemical substance that may cause certain harm to the human body. In the process of operation, attention should be paid to avoid direct contact with the skin and inhalation of its dust, to avoid ingestion or misuse. At the same time, the general operating specifications for chemicals, such as wearing protective gloves and glasses, should be observed, and the working environment should be well ventilated.
Last Update：2024-04-10 22:29:15
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View History
葫蔓藤碱甲
(二乙胺基)二甲基硅烷
1-BOC-2-异丙基肼
Bismuthate (BiO31-), sodium
[6]Cycloparaphenylene
(1s)-8-dioxabicyclo(3.2.1)oct-2-en-4-one
聚亚甲基聚芳基异氰酸酯
monoethylphosphoric acid
N,N-DIMETHYLPIVALAMIDE
3'-氯-4-氟苯丙酮
(二乙胺基)二甲基硅烷
1-BOC-2-异丙基肼
Bismuthate (BiO31-), sodium
[6]Cycloparaphenylene
(1s)-8-dioxabicyclo(3.2.1)oct-2-en-4-one
聚亚甲基聚芳基异氰酸酯
monoethylphosphoric acid
N,N-DIMETHYLPIVALAMIDE
3'-氯-4-氟苯丙酮