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蘇拉明鈉

Suramin sodium salt

CAS: 129-46-4

Molecular Formula: C51H34N6Na6O23S6

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蘇拉明鈉 - Names and Identifiers

Name Suramin sodium salt
Synonyms SURAMIN
reasodiumsalt
sodiumsuramin
Suramin sodium
Suramin sodium salt
Suramin hexasodium salt
8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfoni
CAS 129-46-4
EINECS 204-949-3

蘇拉明鈉 - Physico-chemical Properties

Molecular FormulaC51H34N6Na6O23S6
Molar Mass1429.17
Melting Point>260°C (dec.)
Water Solubilitysoluble
Solubility H2O: >10mg/mL
AppearanceMorphological Crystalline Powder
ColorWhite
BRN3694087
PHpH(10g/l, 25℃) : 5.0~8.0
Storage Condition0-6°C
StabilityHygroscopic
Physical and Chemical PropertiesBioactive Suramin sodium hexasodium (Suramin) is a reversible and competitive protein tyrosine phosphatase (PTPases) inhibitor. Suramin sodium salt is a potent sirtuins inhibitor: SirT1 (IC50=297 nM),SirT2 (IC50=1.15 μM),SirT5 (IC50=22 μM). Suramin sodium salt is a competitive reverse transcriptase inhibitor (DNA topoisomerase II: IC50 = 5 μM). Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor. Suramin sodium salt effectively inhibits IP5K and is an antiparasitic (antiparasitic), antitumor and antiangiogenic agent.
UseThe application of suramin sodium has been proved to have anti-trypanosomiasis, anti-tumor, prevention and treatment of ocular proliferative diseases, anti-virus, immunomodulatory effects, and widely used in clinical practice. At present, there is no report that suramin sodium has anti-coccidia effect. Through the known properties of suramin sodium, it is impossible to infer whether it has anti-coccidia effect. Suramin sodium salt, is a hepatitis C virus NS3 helicase inhibitor. It is also used to treat arthritis caused by collagen problems.

蘇拉明鈉 - Risk and Safety

Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
WGK Germany3
RTECSQM7000000
FLUKA BRAND F CODES3-10
HS Code29242998
ToxicityLD50 in mice (mg/kg): ~620 i.v. (Hawking)

蘇拉明鈉 - Preparation solution concentration reference

 1mg5mg10mg
1 mM0.7 ml3.499 ml6.997 ml
5 mM0.14 ml0.7 ml1.399 ml
10 mM0.07 ml0.35 ml0.7 ml
5 mM0.014 ml0.07 ml0.14 ml
Last Update:2024-01-02 23:10:35
蘇拉明鈉
Supplier List
MedChemExpress (MCE)
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CAS: 129-46-4
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CAS: 129-46-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: Suramin hexasodium salt Visit Supplier Webpage Request for quotation
CAS: 129-46-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
     tech@medchemexpress.com
Mobile: 609-228-6898
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Suramin hexasodium salt Visit Supplier Webpage Request for quotation
CAS: 129-46-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: Suramin hexasodium salt Visit Supplier Webpage Request for quotation
CAS: 129-46-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Suramin sodium salt Visit Supplier Webpage Request for quotation
CAS: 129-46-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
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