表鬼臼毒素
(-)-Epipodophyllotoxin
CAS: 4375-07-9
Molecular Formula: C22H22O8
表鬼臼毒素 - Names and Identifiers
表鬼臼毒素 - Physico-chemical Properties
| Molecular Formula | C22H22O8 |
| Molar Mass | 414.40528 |
| Density | 1.2649 (rough estimate) |
| Melting Point | 160.3°C |
| Boling Point | 453.31°C (rough estimate) |
| Solubility | Soluble in chloroform, acetone, ethyl acetate and benzene, soluble in ethanol, ether, insoluble in water. |
| Appearance | White or white-like crystalline powder |
| Color | White to Off-White |
| pKa | 13.26±0.40(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.4480 (estimate) |
| MDL | MFCD01725610 |
表鬼臼毒素 - Reference Information
| Introduction | epipodophyllotoxin is a lignan-like compound isolated from the rhizomes of podophyllaceae, has significant anti-tumor activity, mainly through the role of tubulin and DNA topoisomerase II to produce cytotoxic activity to play an anti-tumor effect, but because of its stomach and intestinal toxicity, therefore, it is not suitable for direct clinical application. |
| clinical research | in recent years, epipodophyllotoxin derivatives with better pharmacological and pharmacokinetic properties have been found, such as NK-611, GL-331, TOP-53, F11782 and F14512, etc., of which GL-331 can overcome the multi-drug resistance caused by a variety of tumor cell lines, has now entered the phase 2 clinical trials; TOP-53 has shown a strong inhibitory effect on the highly resistant mutant yeast type 2 enzyme, which has entered the phase 1 clinical trial. |
| biological activity | (-)-Epipodophyllotoxin is a cancer cell antiproliferative agent isolated from Podophyllum peltatum, GI50 values in HeLa cells and MCF-7 cells were 0.36 and 0.24 μm, respectively. (-)-Epipodophyllotoxin inhibits mitotic spindle assembly in vitro. |
Last Update：2024-04-09 21:54:55
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