表鬼臼毒素标准品
(-)-Epipodophyllotoxin
CAS: 4375-07-9
Molecular Formula: C22H22O8
表鬼臼毒素标准品 - Names and Identifiers
表鬼臼毒素标准品 - Physico-chemical Properties
| Molecular Formula | C22H22O8 |
| Molar Mass | 414.40528 |
| Density | 1.2649 (rough estimate) |
| Melting Point | 160.3°C |
| Boling Point | 453.31°C (rough estimate) |
| Solubility | Soluble in chloroform, acetone, ethyl acetate and benzene, soluble in ethanol, ether, insoluble in water. |
| Appearance | White or white-like crystalline powder |
| Color | White to Off-White |
| pKa | 13.26±0.40(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Refractive Index | 1.4480 (estimate) |
| MDL | MFCD01725610 |
表鬼臼毒素标准品 - Reference Information
| Introduction | epipodophyllotoxin is a lignan-like compound isolated from the rhizomes of podophyllaceae, has significant anti-tumor activity, mainly through the role of tubulin and DNA topoisomerase II to produce cytotoxic activity to play an anti-tumor effect, but because of its stomach and intestinal toxicity, therefore, it is not suitable for direct clinical application. |
| clinical research | in recent years, epipodophyllotoxin derivatives with better pharmacological and pharmacokinetic properties have been found, such as NK-611, GL-331, TOP-53, F11782 and F14512, etc., of which GL-331 can overcome the multi-drug resistance caused by a variety of tumor cell lines, has now entered the phase 2 clinical trials; TOP-53 has shown a strong inhibitory effect on the highly resistant mutant yeast type 2 enzyme, which has entered the phase 1 clinical trial. |
| biological activity | (-)-Epipodophyllotoxin is a cancer cell antiproliferative agent isolated from Podophyllum peltatum, GI50 values in HeLa cells and MCF-7 cells were 0.36 and 0.24 μm, respectively. (-)-Epipodophyllotoxin inhibits mitotic spindle assembly in vitro. |
Last Update：2024-04-09 21:54:55
Supplier List
Spot supply
Product Name: (-)-Epipodophyllotoxin Visit Supplier Webpage Request for quotationCAS: 4375-07-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: (-)-Epipodophyllotoxin Visit Supplier Webpage Request for quotationCAS: 4375-07-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: (-)-Epipodophyllotoxin Visit Supplier Webpage Request for quotationCAS: 4375-07-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (-)-Epipodophyllotoxin Visit Supplier Webpage Request for quotationCAS: 4375-07-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: (-)-Epipodophyllotoxin Visit Supplier Webpage Request for quotationCAS: 4375-07-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: (-)-Epipodophyllotoxin Visit Supplier Webpage Request for quotationCAS: 4375-07-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: (-)-Epipodophyllotoxin Visit Supplier Webpage Request for quotationCAS: 4375-07-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: (-)-Epipodophyllotoxin Visit Supplier Webpage Request for quotationCAS: 4375-07-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History