| Name | Tannic acid berberine |
| Synonyms | Tannic acid berberine |
| CAS | 1821200-03-6 |
| overview | berberine tannic acid is an antibacterial drug that will decompose into tannic acid and berberine in intestinal fluid. berberine is an isoquinoline alkaloid existing in Coptis chinensis, which has antibacterial effects on Staphylococcus aureus, Streptococcus hemolyticus, Neisseria gonorrhoeae and Shigella dysentery bacillus, and can enhance the phagocytosis of white blood cells. Berberine tannate Japan Pharmacy has been collecting berberine tannate as a astringent antibacterial drug since the seventh revised version (1966), and the drug standards of Gansu, Shaanxi, Liaoning and other provinces in China have also been collecting it after 1978. Recent studies have also found that berberine tannin combined with cervical cryotherapy or cervical electrosurgical excision technique has a great effect on the treatment of severe cervical erosion. |
| drug overview | drug name: berberine tannate Chinese alias: tasteless berberine foreign name: Berberine Tannate berberine structure diagram | pharmacological action | berberine tannic acid decomposes in intestinal fluid to produce free berberine and tannic acid, which plays an antibacterial and astringent role. Berberine can delay the intestinal drainage of the human body, inhibit the adhesion of bacteria on the surface of mucosa and epithelial cells, and can also significantly increase the ratio of red blood cells, white blood cells, hemoglobin and albumin to globulin. |
| pharmacokinetics | absorption: oral absorption is poor, it can quickly enter various tissues and organs after injection, and the blood drug concentration is maintained for a short time. The blood concentration after intramuscular injection was lower than the minimum inhibitory concentration. Distribution: Drugs are widely distributed, with lung, liver, heart, and bone. metabolism: the retention time in the tissue is short, only trace amount is left after 24 hours, most of the drugs are metabolically cleared in the body, and the original discharge within 48 hours only accounts for less than 5% of the dosage. |
| drug interaction | after tannin-containing drugs are taken together with berberine, tannin can combine with alkaloids to form precipitate, resulting in insoluble tannin precipitate, thus reducing the curative effect of drugs. |
| indications | suitable for enteritis and dysentery caused by dysentery bacillus and e. coli. Incoming studies have shown that the drug has antiarrhythmic effects and can promote islet day cell repair, which can be used to treat diabetes. In addition, there is a certain anti-cancer effect. |
| adverse reactions | oral adverse reactions are few, occasionally vomiting, nausea, rash and drug fever, which disappear after drug withdrawal. |
| precautions | 1. use with caution in the first three months of pregnancy for pregnant women. 2. For those who are allergic to this product, hemolytic anemia patients are prohibited. 3. If serious adverse reactions occur from overdose, please seek medical attention immediately. 4. when the drug properties change should be prohibited. |
| main references | 1. Liu wenjiang et al. improvement of preparation process of berberine tannate [J]. Chinese Journal of Pharmaceuticals 1998,29(6):252 2. Li Xiao. Clinical observation of berberine tannate combined with cervical cryotherapy in the treatment of moderate to severe cervical erosion [J]. Guangzhou Medical 2008,39(6):47-49. 3. Dai Hongbo et al. Observation on therapeutic effect of berberine tannate membrane combined with cervical electrosurgical excision in the treatment of chronic cervicitis [J]. Chin J Misdiagn2010,7(10):5114 4.http://baike.baidu.com/link?url=nAWLvSZ0M2e8EnlR3bV02yx0ajkkrFt36Y0lyh2NX3w7tTkpgDvshnJb8pgWPBbJzyN5fQhLoTb9SyoVQmQTgWGlgwYSGlrKFAHTCQoqv1ir02C5nC7-0kqgUwLM7tZI 5. Xu Xuejun et al. New clinical use of berberine. Chinese Pharmacological Bulletin [J]. 1990,05:289 |
| use | antibacterial drug for treating intestinal infection caused by dysentery bacillus |