TS-011 MedChemExpress (MCE)

Product Name	(E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide
Synonyms	(E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide
CAS	339071-18-0
EINECS
Chemical Formula	C11H14ClN3O2
Molecular Weight	255.70076
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	TS-011 TS-011 MedChemExpress (MCE) HY-15603 339071-18-0 99.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions TS-011 TS-011 MedChemExpress (MCE) HY-15603 339071-18-0 99.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis. TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P[1]. In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%[2]. The studies are performed using 58 male C57BL/6J mice (8 weeks old) weighing 20 to 26 g. TS-011 (0.3 mg/kg) or a vehicle is infused intravenously for 1 h every 6 h in a mouse model of stroke, induced by transient occlusion of the middle cerebral artery occlusion following photothrombosis. The cerebral blood flow velocity and the vascular perfusion area of the peri-infarct microvessels are measured using in vivo two-photon imaging[1]. \| \| \| \| \| \| \| \| \| \| [1]. Marumo T, et al. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol. 2010 Nov 161(6):1391-402. [Content Brief] [2]. Hacein-Bey L, et al. Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2006 Jun-Jul 27(6):1350-4. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-04-01 14:45:47

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-04-01 14:45:47

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-04-01 14:45:47

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-04-01 14:45:47

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-04-01 14:45:47

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-04-01 14:45:47

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-04-01 14:45:47

Thalidomide-PEG4-NH2

Category: Signaling Pathways
CAS: 2387510-82-7
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact