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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NameAminoacridine
SynonymsAminacrin;Izoacridina;Aminoacridine;9-acridinamine;9-Aminoakridin;9-amino-acridin;Acridin-9-amine;9-aminoacridine;Acridine, 9-amino-
CAS90-45-9
EINECS201-995-6
Chemical FormulaC13H10N2
Molecular Weight194.23
inchiInChI=1/C13H10N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H,(H2,14,15)
Package10 mM * 1 mL;250 mg;500 mg;1 g
PriceEmail to quote
Descriptions9-Aminoacridine

9-Aminoacridine

MedChemExpress (MCE)

HY-B1422

90-45-9

Aminacrine

99.35%

4°C, protect from light *In solvent : -80°C, 6 months

Descriptions

9-Aminoacridine

9-Aminoacridine

MedChemExpress (MCE)

HY-B1422

90-45-9

Aminacrine

99.35%

4°C, protect from light *In solvent : -80°C, 6 months
-20°C, 1 month (protect from light)

Room temperature in continental US
may vary elsewhere.

9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF
HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections.

9-Aminoacridine has a strong antimicrobial effect on K. pneumoniae, with MICs from 8 to 16 μg/mL[1]. 9-Aminoacridine (0-64 μg/mL) shows moderate cytotoxicity to normal (LO2, HK2, HMC3) and tumor (HepG2, 786-O, U251) human cell lines, but when used as a RIF adjuvant, the reduced dosage of 9-Aminoacridine further diminishes its toxicity[1].

9-Aminoacridine (Aminacrine
15 mg/kg
subcutaneously) with a single dose decreases the abscess area in the skin subcutaneous abscess mice model[2].

HIV-1

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[1]. S Grzesiek, et al. The 'delta pH'-probe 9-aminoacridine: response time, binding behaviour and dimerization at the membrane. Biochim Biophys Acta. 1988 Mar 3
938(3):411-24. [Content Brief]

[2]. Pengfei She, et al. Repurposing 9-Aminoacridine as an Adjuvant Enhances the Antimicrobial Effects of Rifampin against Multidrug-Resistant Klebsiella pneumonia. Microbiol Spectr. 2023 Jun 15
11(3):e0447422. [Content Brief]

[3]. Irene Guendel, et al. 9-Aminoacridine inhibition of HIV-1 Tat dependent transcription. Virol J. 2009 Jul 24:6:114. [Content Brief]

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