DMA MedChemExpress (MCE)

Product Name	DMA
Synonyms	DMA;2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)-;2'-(3,4-Dimethoxyphenyl)-5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzo[d]imidazole
CAS	188860-26-6
EINECS
Chemical Formula	C27H28N6O2
Molecular Weight	468.55
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	DMA DMA MedChemExpress (MCE) HY-15621 188860-26-6 98.89% 4°C, protect from light In solvent : -80°C, 6 months Descriptions DMA DMA MedChemExpress (MCE) HY-15621 188860-26-6 98.89% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. DMA is a fluorescent compound (λex=340 nm, λem=478 nm). The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC50 is observed at 5.3 μM for DMA. The IC50 determined in the case of HeLa is 3.4 μM for DMA[1]. Various human tumor cells (U87, HeLa and MCF7) are maintained as monolayer at 37°C in 5% CO2 using DMEM medium. Approximately 3000-8000 cells/well are seeded in 96-well plates containing 200 μL of medium and incubated for 24 h. The culture medium is replaced by fresh medium containing 1, 10, 50, 100 μM of DMA (6c) and incubated for 24, 48 and 72 h. The cell viability is determined by the MTT assay. The light absorbance is measured using a microplate reader[1]. IC50: 3.4 μM (HeLa cell), 5.3 μM (MCF7 cell)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Singh M, et al. Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-aryl-substituted 2-bis-1H-benzimidazoles. Eur J Med Chem. 2011 Feb 46(2):659-69. [Content Brief]
Supplier Website	https://www.medchemexpress.com/dma.html
Last Update	2025-05-21 16:50:25

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